Radiotherapy—the not-so-insignificant contributor to cancer-associated venous thrombosis

Venous thromboembolism is a well-established complication in patients with cancer and a leading cause of morbidity and mortality in these subjects. However, the role of radiotherapy in cancer-associated venous thromboembolism (CAT) remains less clearly defined. The incidence of CAT in this population varies widely, with several large-scale studies suggesting an association. Although management of CAT in this population follows standard guidelines, less is known about the appropriateness of thromboprophylaxis in patients with different types of cancer. Patients with cancer undergoing radiotherapy may also be at increased risk of bleeding, which may be further worsened by anticoagulation. A multidisciplinary approach integrating hematology and oncology expertise is essential in this setting. Further research is needed to establish standardized protocols and predictive models to identify those at risk of thrombosis and bleeding while on anticoagulation.