2005-2018年学龄儿童和青少年与贫血相关的微量营养素：反映炎症和贫血营养决定因素的生物标志物（BRINDA）项目

IF 3.2 Q2 NUTRITION & DIETETICS

Current Developments in Nutrition Pub Date : 2025-08-01 DOI:10.1016/j.cdnut.2025.107502

Rochelle Werner , Hanqi Luo , Lei Liu , Yuqing Wang , Jiaxi Geng , Yi-An Ko , Parminder S Suchdev , Yaw Addo , Zulfiqar Ahmed Bhutta , Victor Temple , Frank Wieringa , Fabian Rohner , Maria J Ramirez-Luzuriaga , Reina Engle-Stone , Anne Williams , Melissa F Young , BRINDA Workgroup

{"title":"2005-2018年学龄儿童和青少年与贫血相关的微量营养素：反映炎症和贫血营养决定因素的生物标志物（BRINDA）项目","authors":"Rochelle Werner , Hanqi Luo , Lei Liu , Yuqing Wang , Jiaxi Geng , Yi-An Ko , Parminder S Suchdev , Yaw Addo , Zulfiqar Ahmed Bhutta , Victor Temple , Frank Wieringa , Fabian Rohner , Maria J Ramirez-Luzuriaga , Reina Engle-Stone , Anne Williams , Melissa F Young , BRINDA Workgroup","doi":"10.1016/j.cdnut.2025.107502","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>School-age children and adolescents may be at risk of anemia through demands on micronutrients required for growth and maturation.</div></div><div><h3>Objectives</h3><div>This multicountry analysis examined the burden of anemia in children aged 5–19 y by sex and age category and associations with micronutrient deficiencies, inflammation, and BMI.</div></div><div><h3>Methods</h3><div>Children aged 5–19 y from surveys in the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project were included with hemoglobin, ≥1 micronutrient (iron, vitamin A, folate, vitamin B<sub>12</sub>, or zinc) and inflammation biomarker, and <em>n</em> > 100 per survey. Factors with bivariate relationships with anemia (<em>P</em> < 0.1) were included in multivariable modified Poisson regression models to examine the attributable burden of anemia.</div></div><div><h3>Results</h3><div>This analysis included 54,534 children from 17 surveys in 16 countries (16 surveys for 15–19 y; 9 surveys for 10–14 y; 8 surveys for 5–9 y). Median overall anemia prevalence was 16% (range: 5% in Ecuador, United Kingdom, and United States to 59% in Côte d’Ivoire) with the highest burden in 15–19-y-old females (24%). In most surveys, anemia prevalence did not differ by sex for children aged 5–14 y, and median anemia prevalence was lower in children aged 10–14 y (7%) than in those aged 5–9 y (9%) or 15–19 y (22%). In most surveys, higher anemia prevalence was associated (<em>P</em> < 0.05) with iron deficiency (15%) [prevalence ratio (PR): 1.6–14.2; 5–9 y, 4/7 surveys; 10–14 y, 6/6 surveys; 15–19 y, 13/14 surveys), vitamin A deficiency (2%) (PR: 1.8–3.0; 5–9 y, 2/2 surveys; 10–14 y, 2/3 surveys; 15–19 y, 2/3 surveys), and inflammation (13%) (PR: 1.4–2.4: 5–9 y, 4/4 surveys; 10–14 y, 2/4 surveys; 15–19 y, 6/8 surveys). Folate, vitamin B<sub>12</sub>, zinc, and BMI had weak, variable associations with anemia.</div></div><div><h3>Conclusions</h3><div>Iron deficiency and vitamin A deficiency are consistently associated with anemia in school-age children and adolescents, whereas inflammation and other micronutrients had context-dependent associations. This research underscores the importance of examining multiple micronutrients associated with anemia in the context of factors such as country, age, and sex.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 8","pages":"Article 107502"},"PeriodicalIF":3.2000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Micronutrients Associated With Anemia in School-age Children and Adolescents 2005–2018: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project\",\"authors\":\"Rochelle Werner , Hanqi Luo , Lei Liu , Yuqing Wang , Jiaxi Geng , Yi-An Ko , Parminder S Suchdev , Yaw Addo , Zulfiqar Ahmed Bhutta , Victor Temple , Frank Wieringa , Fabian Rohner , Maria J Ramirez-Luzuriaga , Reina Engle-Stone , Anne Williams , Melissa F Young , BRINDA Workgroup\",\"doi\":\"10.1016/j.cdnut.2025.107502\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>School-age children and adolescents may be at risk of anemia through demands on micronutrients required for growth and maturation.</div></div><div><h3>Objectives</h3><div>This multicountry analysis examined the burden of anemia in children aged 5–19 y by sex and age category and associations with micronutrient deficiencies, inflammation, and BMI.</div></div><div><h3>Methods</h3><div>Children aged 5–19 y from surveys in the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project were included with hemoglobin, ≥1 micronutrient (iron, vitamin A, folate, vitamin B<sub>12</sub>, or zinc) and inflammation biomarker, and <em>n</em> > 100 per survey. Factors with bivariate relationships with anemia (<em>P</em> < 0.1) were included in multivariable modified Poisson regression models to examine the attributable burden of anemia.</div></div><div><h3>Results</h3><div>This analysis included 54,534 children from 17 surveys in 16 countries (16 surveys for 15–19 y; 9 surveys for 10–14 y; 8 surveys for 5–9 y). Median overall anemia prevalence was 16% (range: 5% in Ecuador, United Kingdom, and United States to 59% in Côte d’Ivoire) with the highest burden in 15–19-y-old females (24%). In most surveys, anemia prevalence did not differ by sex for children aged 5–14 y, and median anemia prevalence was lower in children aged 10–14 y (7%) than in those aged 5–9 y (9%) or 15–19 y (22%). In most surveys, higher anemia prevalence was associated (<em>P</em> < 0.05) with iron deficiency (15%) [prevalence ratio (PR): 1.6–14.2; 5–9 y, 4/7 surveys; 10–14 y, 6/6 surveys; 15–19 y, 13/14 surveys), vitamin A deficiency (2%) (PR: 1.8–3.0; 5–9 y, 2/2 surveys; 10–14 y, 2/3 surveys; 15–19 y, 2/3 surveys), and inflammation (13%) (PR: 1.4–2.4: 5–9 y, 4/4 surveys; 10–14 y, 2/4 surveys; 15–19 y, 6/8 surveys). Folate, vitamin B<sub>12</sub>, zinc, and BMI had weak, variable associations with anemia.</div></div><div><h3>Conclusions</h3><div>Iron deficiency and vitamin A deficiency are consistently associated with anemia in school-age children and adolescents, whereas inflammation and other micronutrients had context-dependent associations. This research underscores the importance of examining multiple micronutrients associated with anemia in the context of factors such as country, age, and sex.</div></div>\",\"PeriodicalId\":10756,\"journal\":{\"name\":\"Current Developments in Nutrition\",\"volume\":\"9 8\",\"pages\":\"Article 107502\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Developments in Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2475299125029634\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Developments in Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2475299125029634","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

摘要

学龄儿童和青少年可能由于对生长和成熟所需微量营养素的需求而面临贫血的风险。目的：这项多国分析研究了5-19岁儿童的贫血负担，按性别和年龄分类，以及与微量营养素缺乏、炎症和BMI的关系。方法BRINDA项目调查的5-19岁儿童血红蛋白、≥1种微量营养素（铁、维生素A、叶酸、维生素B12或锌）和炎症生物标志物，n >；每次调查100。与贫血有双变量关系的因素(P <；0.1)纳入多变量修正泊松回归模型，以检验贫血的归因负担。该分析包括来自16个国家17项调查的54,534名儿童(16项调查为15-19岁；10-14岁9次调查；8个调查为5 - 9y)。总体贫血患病率中位数为16%（范围：厄瓜多尔、英国和美国为5%，Côte科特迪瓦为59%），15 - 19岁女性负担最高（24%）。在大多数调查中，5-14岁儿童的贫血患病率没有性别差异，10-14岁儿童的中位贫血患病率（7%）低于5-9岁儿童（9%）或15-19岁儿童（22%）。在大多数调查中，较高的贫血患病率与此相关(P <；0.05)缺铁（15%）[患病率（PR）： 1.6 ~ 14.2；5-9 y， 4/7次调查；10 - 14y， 6/6次调查；15-19岁，13/14调查)，维生素A缺乏症（2%）(PR: 1.8-3.0；5-9次，2/2次调查；10-14岁，2/3调查；15-19岁，2/3调查)，炎症（13%）(PR: 1.4-2.4； 5-9岁，4/4调查；10 - 14y， 2/4次调查；15-19岁，6/8次调查)。叶酸、维生素B12、锌和BMI与贫血有微弱的、可变的关联。结论：铁缺乏和维生素A缺乏与学龄儿童和青少年的贫血一致相关，而炎症和其他微量营养素具有情境依赖性。这项研究强调了在国家、年龄和性别等因素的背景下检查与贫血相关的多种微量营养素的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Micronutrients Associated With Anemia in School-age Children and Adolescents 2005–2018: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project

Background

School-age children and adolescents may be at risk of anemia through demands on micronutrients required for growth and maturation.

Objectives

This multicountry analysis examined the burden of anemia in children aged 5–19 y by sex and age category and associations with micronutrient deficiencies, inflammation, and BMI.

Methods

Children aged 5–19 y from surveys in the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project were included with hemoglobin, ≥1 micronutrient (iron, vitamin A, folate, vitamin B₁₂, or zinc) and inflammation biomarker, and n > 100 per survey. Factors with bivariate relationships with anemia (P < 0.1) were included in multivariable modified Poisson regression models to examine the attributable burden of anemia.

Results

This analysis included 54,534 children from 17 surveys in 16 countries (16 surveys for 15–19 y; 9 surveys for 10–14 y; 8 surveys for 5–9 y). Median overall anemia prevalence was 16% (range: 5% in Ecuador, United Kingdom, and United States to 59% in Côte d’Ivoire) with the highest burden in 15–19-y-old females (24%). In most surveys, anemia prevalence did not differ by sex for children aged 5–14 y, and median anemia prevalence was lower in children aged 10–14 y (7%) than in those aged 5–9 y (9%) or 15–19 y (22%). In most surveys, higher anemia prevalence was associated (P < 0.05) with iron deficiency (15%) [prevalence ratio (PR): 1.6–14.2; 5–9 y, 4/7 surveys; 10–14 y, 6/6 surveys; 15–19 y, 13/14 surveys), vitamin A deficiency (2%) (PR: 1.8–3.0; 5–9 y, 2/2 surveys; 10–14 y, 2/3 surveys; 15–19 y, 2/3 surveys), and inflammation (13%) (PR: 1.4–2.4: 5–9 y, 4/4 surveys; 10–14 y, 2/4 surveys; 15–19 y, 6/8 surveys). Folate, vitamin B₁₂, zinc, and BMI had weak, variable associations with anemia.

Conclusions

Iron deficiency and vitamin A deficiency are consistently associated with anemia in school-age children and adolescents, whereas inflammation and other micronutrients had context-dependent associations. This research underscores the importance of examining multiple micronutrients associated with anemia in the context of factors such as country, age, and sex.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊