骨髓脂肪组织和骨髓脂肪细胞的实验分析：来自骨髓脂肪学会（BMAS）的最新进展

IF 2.6 Q3 ENDOCRINOLOGY & METABOLISM

Bone Reports Pub Date : 2025-07-28 DOI:10.1016/j.bonr.2025.101861

Michaela Tencerova , Biagio Palmisano , Stéphanie Lucas , Camille Attané , Kaisa K. Ivaska , Léa Loisay , Yoshiko M. Ikushima , Drenka Trivanovic , Alessandro Corsi , Adriana Roque , Hongshuai Li , Friederike Behler-Janbeck , Jeroen Geurts , Mara Riminucci , Izabela Podgorski , William P. Cawthorn , Bram C.J. van der Eerden , André J. van Wijnen

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引用次数: 0

摘要

骨髓脂肪组织（BMAT）在生理上与骨和能量代谢、内分泌调节、造血和癌症相关过程有关。该领域的一个关键挑战是分离BMAT或骨髓脂肪细胞（BMAds）的方法是可变的，因为没有广泛采用的标准化方案。为了提高对这一挑战的认识，并在需要分离、储存和表征BMAT和BMAds的实验方法上建立一致性，国际骨髓肥胖协会（BMAS）的生物银行工作组先前推荐了实验标准。本文提供了这项工作的最新进展，并介绍了目前最先进的分离和表征BMAT和BMAds的方法和技术考虑，包括目前可用的高通量组学方法。这篇综述提供了一个参考点，基于BMAS研究者的共识，以支持与骨髓肥胖相关的生物医学、生物学、生化和生物物理问题的研究。

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Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS)

Bone marrow adipose tissue (BMAT) is physiologically linked to bone and energy metabolism, endocrine regulation, hematopoiesis and cancer-related processes. A key challenge in the field is that methods for isolating BMAT or bone marrow adipocytes (BMAds) are variable because there are no widely adopted standardized protocols. To generate awareness of this challenge and to establish uniformity in experimental approaches requiring isolation, storage and characterization of BMAT and BMAds, the Biobanking Working Group of the international Bone Marrow Adiposity Society (BMAS) has previously recommended experimental standards. This paper provides an update on this effort and presents current state-of-the-art methods and technical considerations for isolation and characterization of BMAT and BMAds, including currently available high-throughput omics approaches. This review provides a reference point based on the consensus view of BMAS investigators to support studies on biomedical, biological, biochemical and biophysical questions associated with bone marrow adiposity.

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来源期刊

Bone Reports Medicine-Orthopedics and Sports Medicine

CiteScore

4.30

自引率

4.00%

发文量

444

审稿时长

57 days

期刊介绍： Bone Reports is an interdisciplinary forum for the rapid publication of Original Research Articles and Case Reports across basic, translational and clinical aspects of bone and mineral metabolism. The journal publishes papers that are scientifically sound, with the peer review process focused principally on verifying sound methodologies, and correct data analysis and interpretation. We welcome studies either replicating or failing to replicate a previous study, and null findings. We fulfil a critical and current need to enhance research by publishing reproducibility studies and null findings.