sTREM2在威胁生命事件和抑郁之间的中介作用

IF 2.5 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2025-08-09 DOI:10.1016/j.jneuroim.2025.578719

Alejandro Olaviaga , Leandro Nicolás Grendas , Luciana Carla Chiapella , Romina Isabel Álvarez Casiani , Ángeles Romina Arena , Vera Tifner , Cintia Romina Prokopez , Eugenio Antonio Carrera Silva , Andrea Emilse Errasti , Federico Manuel Daray

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引用次数: 0

摘要

抑郁症是一种非常普遍且致残的疾病，影响着全球约2.8亿人。新出现的证据表明，神经炎症在抑郁症的病理生理学中起着重要作用。髓样细胞表达的可溶性触发受体-2 （strem -2）已被确定为神经炎症的潜在标志物。目的探讨sTREM2在重性抑郁发作（MDE）患者威胁事件表测量的感知压力与当前抑郁症状之间的关系中的潜在中介作用。方法采用多中心病例对照研究的数据进行二次分析，该研究纳入了39例MDE患者和42例健康对照者。等离子体strem - 2水平采用基于头部的多重检测。抑郁症采用汉密尔顿抑郁评定量表（HDRS-17）进行评估，威胁生命事件（LTE）采用压力生活事件量表进行量化。通过中介分析探讨sTREM2在抑郁与LTE关系中的作用。结果MDE患者血浆strem - 2水平高于HC患者（p = 0.006）。近期应激与sTREM2呈正相关（p = 0.032）， LTE评分和sTREM2水平均是当前MDE的显著预测因子（p = 0.009, p = 0.035）。中介分析显示，sTREM2在近期压力与抑郁之间的关系中占17% （p = 0.028）。结论我们的研究结果表明，sTREM2可能在应激和抑郁之间的联系中发挥中介作用，强调神经炎症是抑郁症发展的潜在途径。

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sTREM2 as a mediator in the association between life-threatening events and depression

Background

Depression is a highly prevalent and disabling condition, affecting approximately 280 million people globally. Emerging evidence points to a significant role of neuroinflammation in the pathophysiology of depression. The soluble triggering receptor expressed on myeloid cells-2 (sTREM2) has been identified as a potential marker of neuroinflammation.

Objective

This study aims to investigate the potential mediating role of sTREM2 in the relationship between perceived stress, measured by the List of Threatening Events, and current depressive symptoms in patients with major depressive episodes (MDE).

Methods

This secondary analysis was conducted on data from a multicenter, case-control study of participants with current MDE (n = 39) and healthy controls (HC, n = 42). Plasma sTREM2 levels were measured using bead-based multiplex assays. Depression was assessed using the Hamilton Depression Rating Scale (HDRS-17) and Life-Threatening Events (LTE) were quantified with the Stressful Life Events Scale. A mediation analysis was conducted to explore the role of sTREM2 in the relationship between depression and LTE.

Results

Patients with current MDE exhibited higher plasma sTREM2 levels compared to HC (p = 0.006). Recent stress was positively associated with sTREM2 (p = 0.032), and both LTE scores and sTREM2 levels were significant predictors of current MDE (p = 0.009, p = 0.035). Mediation analysis showed that sTREM2 accounted for 17 % of the relationship between recent stress and depression (p = 0.028).

Conclusion

Our findings suggest that sTREM2 may play a mediating role in the link between stress and depression, highlighting neuroinflammation as a potential pathway in the development of depression.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.