用于肿瘤细胞高保真放大成像的双变量门控DNA纳米反应器

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-08-13 DOI:10.1039/d5cc03986j

Kun Chen, Ming Jin, Jianghui Shi, Jing Tang, Xueying Qiu, Ke Quan, Zhihe Qing

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引用次数: 0

摘要

在这里，我们报告了一种双变量门控DNA纳米反应器，通过扩增的miRNA-21检测实现高保真肿瘤细胞成像。内源性无尿嘧啶/无嘧啶内切酶1 （APE1）激活脚点解锁以防止泄漏，而空间限制排除了pre-miRNA干扰。这一策略将癌细胞与正常细胞区分开来，假阳性最小，从而实现可靠的癌症诊断。

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Bivariate-Gated DNA Nanoreactors for High-Fidelity Amplified Imaging of Tumor Cells

Here, we report a bivariate-gated DNA nanoreactor enabling high-fidelity tumor cell imaging via amplified miRNA-21 detection. Endogenous apurinic/apyrimidinic endonuclease 1 (APE1) activates toehold unlocking to prevent leakage, while spatial confinement excludes pre-miRNA interference. This strategy distinguishes cancer cells from normal cells with minimal false positives, enabling reliable cancer diagnostics.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.