Khalid Boussaine, Philippine Chartier, Alison Cartereau, Daniel Auguin, Emiliane Taillebois, Steeve H Thany
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New insight into the tick neuronal nicotinic acetylcholine receptors: from molecular to pharmacological studies.
ACh is known to be an excitatory neurotransmitter in the central nervous system of several arthropod species. Nicotinic acetylcholine receptors are involved in rapid neurotransmission and are the target of compounds used as acaricides. In the present review, we discuss recent data on the study of the functional properties of tick neuronal nicotinic acetylcholine receptor subtypes present in the synganglion. Several nicotinic acetylcholine receptor subunits have been characterized in tick species. We show that despite difficulties expressing functional receptors in heterologous systems, recent advances using the microtransplantation of tick synganglion membranes in Xenopus oocytes, and electrophysiological recordings of native neurons help to understand the pharmacological properties of tick nicotinic receptors. In addition, molecular modeling studies provide new criteria in the study of ligand-receptor interactions.
期刊介绍：
Ticks and Tick-borne Diseases is an international, peer-reviewed scientific journal. It publishes original research papers, short communications, state-of-the-art mini-reviews, letters to the editor, clinical-case studies, announcements of pertinent international meetings, and editorials.
The journal covers a broad spectrum and brings together various disciplines, for example, zoology, microbiology, molecular biology, genetics, mathematical modelling, veterinary and human medicine. Multidisciplinary approaches and the use of conventional and novel methods/methodologies (in the field and in the laboratory) are crucial for deeper understanding of the natural processes and human behaviour/activities that result in human or animal diseases and in economic effects of ticks and tick-borne pathogens. Such understanding is essential for management of tick populations and tick-borne diseases in an effective and environmentally acceptable manner.
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