{"title":"男孩中枢性性早熟；诊断、治疗和随访：一项全国性的研究。","authors":"Sevinc Odabasi Gunes, Merve Sakar, Nursel Muratoglu Sahin, Gulay Karaguzel, Emine Ayca Cimbek, Feyza Darendeliler, Ezgi Sarban, Esra Doger, Ganimet Oner, Zeynep Siklar, Gizem Senyazar, Murat Aydin, Behzat Ozkan, Ozlem Sangun, Mesut Parlak, Onur Akin, Kadriye Cansu Sahin, İhsan Esen, Aylin Kilinc Ugurlu, Gulcan Seymen, Semih Bolu, Elif Sobu, Servan Ozalkak, Emine Demet Akbas, Gonul Buyukyilmaz, Beray Selver Eklioglu, Ahmet Ucar, Pinar Kocaay, Selma Tunc, Serpil Bas, İsmail Dundar, Eda Celebi Bitkin, Ayca Torel Ergur, Dilek Bingol Aydin, Birgul Kirel, Aysun Ata, Muge Atar, Mehmet Isakoca, Emel Hatun Aytac Kaplan, Tugba Kontbay, Derya Tepe, Oya Ercan, Mehmet Boyraz, Nesibe Akyurek, Edip Unal, Nurhan Ozcan Murat, Serkan Bilge Koca, Zumrut Kocabey Sutcu, Feyza Nehir Oznur Muz, Semra Cetinkaya","doi":"10.1007/s12020-025-04382-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate demographic characteristics, clinical, laboratory, imaging features, and treatment responses of boys who were diagnosed and treated for central precocious puberty (CPP).</p><p><strong>Methods: </strong>The data were collected from pediatric endocrinology clinics in Türkiye. Patients were classified into two groups based on magnetic resonance imaging (MRI) findings, idiopathic CPP (iCPP) and organic CPP (oCPP). The oCPP group was further cathegorized into three subgroups: oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain lesions.</p><p><strong>Results: </strong>Among 232 patients, 62.9% were diagnosed with iCPP. All patients aged <3 years had oCPP-confirmed lesions. Basal luteinizing hormone (LH) and total testosterone (T) levels were higher in oCPP group than in iCPP group (p = 0.004 and p = 0.02, respectively). Basal LH, basal follicle-stimulating hormone (FSH), T, and peak LH/FSH were lower in the iCPP-obese group (p < 0.05). T differed significantly among the oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain subgroups (p = 0.032). Among patients that reached final height (FH), the difference between target height (TH) standard deviation score (SDS) and FH SDS was higher in oCPP group than in iCPP group (p < 0.05). A positive correlation was found between predicted adult height at the treatment initiation and FH (r = 0.463 p = 0.020). Factors affecting FH were height SDS at the beginning of treatment, paternal height SDS, and TH SDS.</p><p><strong>Conclusions: </strong>The prevelance of oCPP was found lower compared with previous literature data. Currently, there is no reliable marker to predict oCPP that would allow clinicians to safely omit MRI in iCPP cases. However, boys under 3 years of age should be carefully evaluated for potential organic causes of CPP.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Central precocious puberty in boys; diagnosis, treatment and follow-up: a nation-wide study.\",\"authors\":\"Sevinc Odabasi Gunes, Merve Sakar, Nursel Muratoglu Sahin, Gulay Karaguzel, Emine Ayca Cimbek, Feyza Darendeliler, Ezgi Sarban, Esra Doger, Ganimet Oner, Zeynep Siklar, Gizem Senyazar, Murat Aydin, Behzat Ozkan, Ozlem Sangun, Mesut Parlak, Onur Akin, Kadriye Cansu Sahin, İhsan Esen, Aylin Kilinc Ugurlu, Gulcan Seymen, Semih Bolu, Elif Sobu, Servan Ozalkak, Emine Demet Akbas, Gonul Buyukyilmaz, Beray Selver Eklioglu, Ahmet Ucar, Pinar Kocaay, Selma Tunc, Serpil Bas, İsmail Dundar, Eda Celebi Bitkin, Ayca Torel Ergur, Dilek Bingol Aydin, Birgul Kirel, Aysun Ata, Muge Atar, Mehmet Isakoca, Emel Hatun Aytac Kaplan, Tugba Kontbay, Derya Tepe, Oya Ercan, Mehmet Boyraz, Nesibe Akyurek, Edip Unal, Nurhan Ozcan Murat, Serkan Bilge Koca, Zumrut Kocabey Sutcu, Feyza Nehir Oznur Muz, Semra Cetinkaya\",\"doi\":\"10.1007/s12020-025-04382-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate demographic characteristics, clinical, laboratory, imaging features, and treatment responses of boys who were diagnosed and treated for central precocious puberty (CPP).</p><p><strong>Methods: </strong>The data were collected from pediatric endocrinology clinics in Türkiye. Patients were classified into two groups based on magnetic resonance imaging (MRI) findings, idiopathic CPP (iCPP) and organic CPP (oCPP). The oCPP group was further cathegorized into three subgroups: oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain lesions.</p><p><strong>Results: </strong>Among 232 patients, 62.9% were diagnosed with iCPP. All patients aged <3 years had oCPP-confirmed lesions. Basal luteinizing hormone (LH) and total testosterone (T) levels were higher in oCPP group than in iCPP group (p = 0.004 and p = 0.02, respectively). Basal LH, basal follicle-stimulating hormone (FSH), T, and peak LH/FSH were lower in the iCPP-obese group (p < 0.05). T differed significantly among the oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain subgroups (p = 0.032). Among patients that reached final height (FH), the difference between target height (TH) standard deviation score (SDS) and FH SDS was higher in oCPP group than in iCPP group (p < 0.05). A positive correlation was found between predicted adult height at the treatment initiation and FH (r = 0.463 p = 0.020). Factors affecting FH were height SDS at the beginning of treatment, paternal height SDS, and TH SDS.</p><p><strong>Conclusions: </strong>The prevelance of oCPP was found lower compared with previous literature data. Currently, there is no reliable marker to predict oCPP that would allow clinicians to safely omit MRI in iCPP cases. However, boys under 3 years of age should be carefully evaluated for potential organic causes of CPP.</p>\",\"PeriodicalId\":49211,\"journal\":{\"name\":\"Endocrine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-08-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12020-025-04382-w\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-025-04382-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Central precocious puberty in boys; diagnosis, treatment and follow-up: a nation-wide study.
Purpose: To evaluate demographic characteristics, clinical, laboratory, imaging features, and treatment responses of boys who were diagnosed and treated for central precocious puberty (CPP).
Methods: The data were collected from pediatric endocrinology clinics in Türkiye. Patients were classified into two groups based on magnetic resonance imaging (MRI) findings, idiopathic CPP (iCPP) and organic CPP (oCPP). The oCPP group was further cathegorized into three subgroups: oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain lesions.
Results: Among 232 patients, 62.9% were diagnosed with iCPP. All patients aged <3 years had oCPP-confirmed lesions. Basal luteinizing hormone (LH) and total testosterone (T) levels were higher in oCPP group than in iCPP group (p = 0.004 and p = 0.02, respectively). Basal LH, basal follicle-stimulating hormone (FSH), T, and peak LH/FSH were lower in the iCPP-obese group (p < 0.05). T differed significantly among the oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain subgroups (p = 0.032). Among patients that reached final height (FH), the difference between target height (TH) standard deviation score (SDS) and FH SDS was higher in oCPP group than in iCPP group (p < 0.05). A positive correlation was found between predicted adult height at the treatment initiation and FH (r = 0.463 p = 0.020). Factors affecting FH were height SDS at the beginning of treatment, paternal height SDS, and TH SDS.
Conclusions: The prevelance of oCPP was found lower compared with previous literature data. Currently, there is no reliable marker to predict oCPP that would allow clinicians to safely omit MRI in iCPP cases. However, boys under 3 years of age should be carefully evaluated for potential organic causes of CPP.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
