放射激活光动力疗法(radioPDT)诱导脂质过氧化和血管介导的前列腺癌肿瘤消退。

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Abul Kalam Azad, Deepak Dinakaran, Ronald B Moore
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引用次数: 0

摘要

光动力疗法(PDT)是一种很有前途的癌症治疗策略,利用外部光源激活光敏剂,从而产生活性氧(ROS)来靶向和破坏肿瘤细胞。然而,PDT的疗效传统上仅限于表面肿瘤,因为通过深层组织结构的光穿透有限,需要复杂的光纤传输。最近的进展是引入纳米闪烁体作为光敏剂的内部光源,由靶向x射线辐射触发,从而扩大了PDT对深部肿瘤的适用性。虽然PDT的体外肿瘤细胞杀伤机制已被广泛记录,但阐明辐射激活光动力疗法(radioPDT)机制的全面体内研究仍然有限。在这项研究中,我们证明了基于原卟啉ix的放射opdt增加ROS的产生,导致体内PC3前列腺肿瘤细胞被杀死,阻碍肿瘤生长。ROS的产生导致肿瘤血管密度降低,并伴有相应的肿瘤内缺氧,而肿瘤血管成熟度不受影响。这些结果揭示了放射opdt对肿瘤微环境的多方面影响,强调了协同放射治疗策略在癌症治疗中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Radiation activated photodynamic therapy (radioPDT) induces lipid peroxidation and vascular mediated tumor regression of prostate cancer.

Radiation activated photodynamic therapy (radioPDT) induces lipid peroxidation and vascular mediated tumor regression of prostate cancer.

Radiation activated photodynamic therapy (radioPDT) induces lipid peroxidation and vascular mediated tumor regression of prostate cancer.

Radiation activated photodynamic therapy (radioPDT) induces lipid peroxidation and vascular mediated tumor regression of prostate cancer.

Photodynamic therapy (PDT) represents a promising cancer treatment strategy, leveraging external light sources to activate photosensitizers, which in turn generate reactive oxygen species (ROS) to target and destroy tumor cells. However, PDT's efficacy has traditionally been limited to surface tumors due to limited light penetration through deep tissue structures requiring complex fiber optic delivery. Recent advancements have introduced nanoscintillators as an internal light source for photosensitizers, triggered by targeted X-ray radiation, thus extending the applicability of PDT to deep-seated tumors. While the in vitro tumor cell killing mechanisms of PDT have been extensively documented, comprehensive in vivo studies elucidating the mechanisms underlying radiation-activated photodynamic therapy (radioPDT) remain limited. In this study, we demonstrated that protoporphyrin IX-based radioPDT augments ROS generation, leading to PC3 prostate tumor cell killing in vivo, impeding tumor growth. ROS production led to a reduction in tumor vascular density with corresponding intratumoral hypoxia, while tumor vascular maturity remained unaffected. These results shed light on the multifaceted effects of radioPDT on the tumor microenvironment, emphasizing the potential for synergistic radiotherapeutic strategies in cancer treatment.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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