Hongkuo Cheng, Zheng Zhou, Hao Wang, Xiaochuan Hang
{"title":"优化瑜伽干预对癌症幸存者心理健康的影响——剂量、持续时间和亚组效应的定量评估：贝叶斯和剂量反应荟萃分析","authors":"Hongkuo Cheng, Zheng Zhou, Hao Wang, Xiaochuan Hang","doi":"10.1002/pon.70222","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>As the number of cancer survivors increases, so does the number of them facing serious mental health problems, including anxiety and depression, which seriously affect their quality of life and prognosis for recovery. Yoga, as a form of mind-body integration, has shown the potential to alleviate psychological distress in cancer survivors. However, previous meta-analyses have some limitations.</p><p><strong>Objective: </strong>This study aimed to accurately assess the overall effect of yoga on depression and anxiety in cancer survivors and its clinical significance through a Bayesian multilevel meta-analysis and to delve deeper into the dose-response relationship and differences in the effect of key subgroups.</p><p><strong>Methods: </strong>MEDLINE, Embase, Cochrane Library, and Web of Science databases up to April 2025 were systematically searched to include randomized controlled trials (RCTs) assessing the effects of yoga on anxiety and depression in adult cancer survivors. Data were synthesized using Bayesian multilevel random-effects models, and differences in treatment effect (Hedges' g), dose-response relationships, moderators (age, sex), and chemoradiotherapy subgroups were analyzed.</p><p><strong>Results: </strong>A total of 32 RCTs (1913 participants) were included. Results showed that yoga significantly improved depressive symptoms (Hedges' g = -0.26, 95% CrI: -0.34 to -0.19) and anxiety symptoms (Hedges' g = -0.41, 95% CrI: -0.51 to -0.31), both achieving the minimal clinically important difference. In addition, the significant dose range for depression improvement was approximately 70-380 MET-minutes/week; for anxiety, approximately 70-240 MET-minutes/week. Furthermore, while age and sex did not significantly moderate the outcomes, yoga was particularly effective in improving anxiety among patients undergoing chemoradiotherapy. The overall quality of the evidence was rated as \"low.\"</p><p><strong>Conclusions: </strong>This study provides new evidence for the effectiveness of yoga in improving depression and anxiety in cancer survivors and reveals specific dose-effect relationships. These findings support the use of yoga as a promising non-pharmacologic adjunctive therapy to promote psychological recovery and quality of life for cancer survivors.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 8","pages":"e70222"},"PeriodicalIF":3.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optimizing Yoga Interventions for Mental Health in Cancer Survivors-A Quantitative Assessment of Dose, Duration, and Subgroup Effects: A Bayesian and Dose-Response Meta-Analysis.\",\"authors\":\"Hongkuo Cheng, Zheng Zhou, Hao Wang, Xiaochuan Hang\",\"doi\":\"10.1002/pon.70222\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>As the number of cancer survivors increases, so does the number of them facing serious mental health problems, including anxiety and depression, which seriously affect their quality of life and prognosis for recovery. Yoga, as a form of mind-body integration, has shown the potential to alleviate psychological distress in cancer survivors. However, previous meta-analyses have some limitations.</p><p><strong>Objective: </strong>This study aimed to accurately assess the overall effect of yoga on depression and anxiety in cancer survivors and its clinical significance through a Bayesian multilevel meta-analysis and to delve deeper into the dose-response relationship and differences in the effect of key subgroups.</p><p><strong>Methods: </strong>MEDLINE, Embase, Cochrane Library, and Web of Science databases up to April 2025 were systematically searched to include randomized controlled trials (RCTs) assessing the effects of yoga on anxiety and depression in adult cancer survivors. Data were synthesized using Bayesian multilevel random-effects models, and differences in treatment effect (Hedges' g), dose-response relationships, moderators (age, sex), and chemoradiotherapy subgroups were analyzed.</p><p><strong>Results: </strong>A total of 32 RCTs (1913 participants) were included. Results showed that yoga significantly improved depressive symptoms (Hedges' g = -0.26, 95% CrI: -0.34 to -0.19) and anxiety symptoms (Hedges' g = -0.41, 95% CrI: -0.51 to -0.31), both achieving the minimal clinically important difference. In addition, the significant dose range for depression improvement was approximately 70-380 MET-minutes/week; for anxiety, approximately 70-240 MET-minutes/week. Furthermore, while age and sex did not significantly moderate the outcomes, yoga was particularly effective in improving anxiety among patients undergoing chemoradiotherapy. The overall quality of the evidence was rated as \\\"low.\\\"</p><p><strong>Conclusions: </strong>This study provides new evidence for the effectiveness of yoga in improving depression and anxiety in cancer survivors and reveals specific dose-effect relationships. These findings support the use of yoga as a promising non-pharmacologic adjunctive therapy to promote psychological recovery and quality of life for cancer survivors.</p>\",\"PeriodicalId\":20779,\"journal\":{\"name\":\"Psycho‐Oncology\",\"volume\":\"34 8\",\"pages\":\"e70222\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psycho‐Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/pon.70222\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psycho‐Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/pon.70222","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：随着癌症幸存者人数的增加，他们面临严重心理健康问题的人数也在增加，包括焦虑和抑郁，这严重影响了他们的生活质量和康复预后。瑜伽，作为一种身心融合的形式，已经显示出减轻癌症幸存者心理痛苦的潜力。然而，以前的荟萃分析有一些局限性。目的：本研究旨在通过贝叶斯多水平荟萃分析，准确评估瑜伽对癌症幸存者抑郁和焦虑的整体影响及其临床意义，并深入探讨关键亚组的剂量-反应关系和效果差异。方法：系统检索截至2025年4月的MEDLINE、Embase、Cochrane Library和Web of Science数据库，纳入评估瑜伽对成年癌症幸存者焦虑和抑郁影响的随机对照试验（rct）。使用贝叶斯多水平随机效应模型综合数据，并分析治疗效果（Hedges’g）、剂量-反应关系、调节因子（年龄、性别）和放化疗亚组的差异。结果：共纳入32项随机对照试验（RCTs）（受试者1913人）。结果显示，瑜伽显著改善抑郁症状（Hedges' g = -0.26, 95% CrI: -0.34 ~ -0.19）和焦虑症状（Hedges' g = -0.41, 95% CrI: -0.51 ~ -0.31），两者均达到最小的临床重要差异。此外，抑郁症改善的显著剂量范围约为70-380 met分钟/周；对于焦虑症，大约每周70-240分钟。此外，虽然年龄和性别对结果没有显著影响，但瑜伽在改善接受放化疗的患者的焦虑方面特别有效。证据的整体质量被评为“低”。“结论：这项研究为瑜伽在改善癌症幸存者的抑郁和焦虑方面的有效性提供了新的证据，并揭示了特定的剂量效应关系。这些发现支持将瑜伽作为一种有希望的非药物辅助疗法来促进癌症幸存者的心理恢复和生活质量。
Optimizing Yoga Interventions for Mental Health in Cancer Survivors-A Quantitative Assessment of Dose, Duration, and Subgroup Effects: A Bayesian and Dose-Response Meta-Analysis.
Background: As the number of cancer survivors increases, so does the number of them facing serious mental health problems, including anxiety and depression, which seriously affect their quality of life and prognosis for recovery. Yoga, as a form of mind-body integration, has shown the potential to alleviate psychological distress in cancer survivors. However, previous meta-analyses have some limitations.
Objective: This study aimed to accurately assess the overall effect of yoga on depression and anxiety in cancer survivors and its clinical significance through a Bayesian multilevel meta-analysis and to delve deeper into the dose-response relationship and differences in the effect of key subgroups.
Methods: MEDLINE, Embase, Cochrane Library, and Web of Science databases up to April 2025 were systematically searched to include randomized controlled trials (RCTs) assessing the effects of yoga on anxiety and depression in adult cancer survivors. Data were synthesized using Bayesian multilevel random-effects models, and differences in treatment effect (Hedges' g), dose-response relationships, moderators (age, sex), and chemoradiotherapy subgroups were analyzed.
Results: A total of 32 RCTs (1913 participants) were included. Results showed that yoga significantly improved depressive symptoms (Hedges' g = -0.26, 95% CrI: -0.34 to -0.19) and anxiety symptoms (Hedges' g = -0.41, 95% CrI: -0.51 to -0.31), both achieving the minimal clinically important difference. In addition, the significant dose range for depression improvement was approximately 70-380 MET-minutes/week; for anxiety, approximately 70-240 MET-minutes/week. Furthermore, while age and sex did not significantly moderate the outcomes, yoga was particularly effective in improving anxiety among patients undergoing chemoradiotherapy. The overall quality of the evidence was rated as "low."
Conclusions: This study provides new evidence for the effectiveness of yoga in improving depression and anxiety in cancer survivors and reveals specific dose-effect relationships. These findings support the use of yoga as a promising non-pharmacologic adjunctive therapy to promote psychological recovery and quality of life for cancer survivors.
期刊介绍：
Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology.
This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues.
Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
