{"title":"采用双光子聚合法制备的导电光敏树脂微弹簧力传感器。","authors":"Ningning Hu, Yucheng Deng, Lujia Ding, Lijun Men, Wenjun Zhang, Ruixue Yin","doi":"10.1038/s41378-025-00975-7","DOIUrl":null,"url":null,"abstract":"<p><p>The rapid miniaturization of electronic devices has fueled unprecedented demand for flexible, high-performance sensors across fields ranging from medical devices to robotics. Despite advances in fabrication techniques, the development of micro- and nano-scale flexible force sensors with superior sensitivity, stability, and biocompatibility remains a formidable challenge. In this study, we developed a novel conductive photosensitive resin specifically designed for two-photon polymerization, systematically optimized its printing parameters, and improved its structural design, thereby enabling the fabrication of high-precision micro-spring force sensors (MSFS). The proposed photosensitive resin, doped with MXene nanomaterials, combines exceptional mechanical strength and conductivity, overcoming limitations of traditional materials. Using a support vector machine model in machine learning techniques, we optimized the polymerizability of the resin under varied laser parameters, achieving a predictive accuracy of 92.66%. This model significantly reduced trial-and-error in the TPP process, accelerating the discovery of ideal fabrication conditions. Finite element analysis was employed to design and simulate the performance of the MSFS, guiding structural optimization to achieve high sensitivity and mechanical stability. The fabricated MSFS demonstrated outstanding electromechanical performance, with a sensitivity coefficient of 5.65 and a fabrication accuracy within ±50 nm, setting a new standard for MSFS precision. This work not only pushes the boundaries of sensor miniaturization but also introduces a scalable, efficient pathway for the rapid design and fabrication of high-performance flexible sensors. The development of flexible, high-performance microscale force sensors remains a critical challenge for next-generation biomedical and wearable electronics. Here, we report a novel micro-spring force sensor fabricated via two-photon polymerization using a custom-designed conductive photosensitive resin doped with MXene nanosheets. The resin formulation was optimized to balance mechanical strength and electrical conductivity while ensuring high-resolution printability. To accelerate parameter optimization, a support vector machine model was trained to predict polymerization outcomes based on laser conditions and material compositions, achieving a prediction accuracy of 92.66%. Finite element analysis guided the design of the MSFS structure, enabling tunable electromechanical performance. The fabricated MSFS exhibited excellent sensitivity high fabrication precision and long-term stability. These results demonstrate the potential of integrating machine learning, functional nanomaterials, and TPP microfabrication to enable scalable, high-precision production of intelligent microsensors for biomedical and soft robotic applications.</p>","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"149"},"PeriodicalIF":9.9000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339963/pdf/","citationCount":"0","resultStr":"{\"title\":\"Micro-spring force sensors using conductive photosensitive resin fabricated via two-photon polymerization.\",\"authors\":\"Ningning Hu, Yucheng Deng, Lujia Ding, Lijun Men, Wenjun Zhang, Ruixue Yin\",\"doi\":\"10.1038/s41378-025-00975-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The rapid miniaturization of electronic devices has fueled unprecedented demand for flexible, high-performance sensors across fields ranging from medical devices to robotics. Despite advances in fabrication techniques, the development of micro- and nano-scale flexible force sensors with superior sensitivity, stability, and biocompatibility remains a formidable challenge. In this study, we developed a novel conductive photosensitive resin specifically designed for two-photon polymerization, systematically optimized its printing parameters, and improved its structural design, thereby enabling the fabrication of high-precision micro-spring force sensors (MSFS). The proposed photosensitive resin, doped with MXene nanomaterials, combines exceptional mechanical strength and conductivity, overcoming limitations of traditional materials. Using a support vector machine model in machine learning techniques, we optimized the polymerizability of the resin under varied laser parameters, achieving a predictive accuracy of 92.66%. This model significantly reduced trial-and-error in the TPP process, accelerating the discovery of ideal fabrication conditions. Finite element analysis was employed to design and simulate the performance of the MSFS, guiding structural optimization to achieve high sensitivity and mechanical stability. The fabricated MSFS demonstrated outstanding electromechanical performance, with a sensitivity coefficient of 5.65 and a fabrication accuracy within ±50 nm, setting a new standard for MSFS precision. This work not only pushes the boundaries of sensor miniaturization but also introduces a scalable, efficient pathway for the rapid design and fabrication of high-performance flexible sensors. The development of flexible, high-performance microscale force sensors remains a critical challenge for next-generation biomedical and wearable electronics. Here, we report a novel micro-spring force sensor fabricated via two-photon polymerization using a custom-designed conductive photosensitive resin doped with MXene nanosheets. The resin formulation was optimized to balance mechanical strength and electrical conductivity while ensuring high-resolution printability. To accelerate parameter optimization, a support vector machine model was trained to predict polymerization outcomes based on laser conditions and material compositions, achieving a prediction accuracy of 92.66%. Finite element analysis guided the design of the MSFS structure, enabling tunable electromechanical performance. The fabricated MSFS exhibited excellent sensitivity high fabrication precision and long-term stability. These results demonstrate the potential of integrating machine learning, functional nanomaterials, and TPP microfabrication to enable scalable, high-precision production of intelligent microsensors for biomedical and soft robotic applications.</p>\",\"PeriodicalId\":18560,\"journal\":{\"name\":\"Microsystems & Nanoengineering\",\"volume\":\"11 1\",\"pages\":\"149\"},\"PeriodicalIF\":9.9000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339963/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microsystems & Nanoengineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1038/s41378-025-00975-7\",\"RegionNum\":1,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INSTRUMENTS & INSTRUMENTATION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microsystems & Nanoengineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1038/s41378-025-00975-7","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INSTRUMENTS & INSTRUMENTATION","Score":null,"Total":0}
Micro-spring force sensors using conductive photosensitive resin fabricated via two-photon polymerization.
The rapid miniaturization of electronic devices has fueled unprecedented demand for flexible, high-performance sensors across fields ranging from medical devices to robotics. Despite advances in fabrication techniques, the development of micro- and nano-scale flexible force sensors with superior sensitivity, stability, and biocompatibility remains a formidable challenge. In this study, we developed a novel conductive photosensitive resin specifically designed for two-photon polymerization, systematically optimized its printing parameters, and improved its structural design, thereby enabling the fabrication of high-precision micro-spring force sensors (MSFS). The proposed photosensitive resin, doped with MXene nanomaterials, combines exceptional mechanical strength and conductivity, overcoming limitations of traditional materials. Using a support vector machine model in machine learning techniques, we optimized the polymerizability of the resin under varied laser parameters, achieving a predictive accuracy of 92.66%. This model significantly reduced trial-and-error in the TPP process, accelerating the discovery of ideal fabrication conditions. Finite element analysis was employed to design and simulate the performance of the MSFS, guiding structural optimization to achieve high sensitivity and mechanical stability. The fabricated MSFS demonstrated outstanding electromechanical performance, with a sensitivity coefficient of 5.65 and a fabrication accuracy within ±50 nm, setting a new standard for MSFS precision. This work not only pushes the boundaries of sensor miniaturization but also introduces a scalable, efficient pathway for the rapid design and fabrication of high-performance flexible sensors. The development of flexible, high-performance microscale force sensors remains a critical challenge for next-generation biomedical and wearable electronics. Here, we report a novel micro-spring force sensor fabricated via two-photon polymerization using a custom-designed conductive photosensitive resin doped with MXene nanosheets. The resin formulation was optimized to balance mechanical strength and electrical conductivity while ensuring high-resolution printability. To accelerate parameter optimization, a support vector machine model was trained to predict polymerization outcomes based on laser conditions and material compositions, achieving a prediction accuracy of 92.66%. Finite element analysis guided the design of the MSFS structure, enabling tunable electromechanical performance. The fabricated MSFS exhibited excellent sensitivity high fabrication precision and long-term stability. These results demonstrate the potential of integrating machine learning, functional nanomaterials, and TPP microfabrication to enable scalable, high-precision production of intelligent microsensors for biomedical and soft robotic applications.
期刊介绍:
Microsystems & Nanoengineering is a comprehensive online journal that focuses on the field of Micro and Nano Electro Mechanical Systems (MEMS and NEMS). It provides a platform for researchers to share their original research findings and review articles in this area. The journal covers a wide range of topics, from fundamental research to practical applications. Published by Springer Nature, in collaboration with the Aerospace Information Research Institute, Chinese Academy of Sciences, and with the support of the State Key Laboratory of Transducer Technology, it is an esteemed publication in the field. As an open access journal, it offers free access to its content, allowing readers from around the world to benefit from the latest developments in MEMS and NEMS.