探索紫杉醇、柚皮素和槲皮素的治疗潜力:结构见解、作用机制和药物开发前景。

IF 1.7 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS
Komal, Lovekesh Singh
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引用次数: 0

摘要

本文综述了紫杉醇、柚皮素和槲皮素的药物、抗癌和食品特性,同时强调了它们的治疗途径和分子功能。化疗药物紫杉醇稳定微管以阻止细胞周期,柚皮素和槲皮素显示出强大的抗癌反应、抗氧化作用和抗炎作用。这篇综述解释了这些化合物如何与它们的药理机制一起用于癌症治疗,并描述了新的药物传递系统如何提高它们的治疗潜力和生物利用度。药物测试证据以及专利文件显示,这些药物化合物在癌症治疗中受到越来越多的关注。紫杉醇、柚皮素和槲皮素这三种化合物作为癌症治疗和预防药物显示出巨大的潜力,而研究人员正在通过持续的研究继续开发它们的临床性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Therapeutic Potential of Paclitaxel, Naringenin, and Quercetin: Structural Insights, Mechanisms of Action, and Drug Development Perspectives.

This review examines the drug-like, cancer-suppressing, and food-based properties of paclitaxel, naringenin, and quercetin while emphasizing their therapeutic pathways and molecular functions. The chemotherapeutic agent paclitaxel stabilizes microtubules for cell cycle arrest, and naringenin alongside quercetin shows strong anticancer responses, antioxidant effects, and anti-inflammatory actions. The review explains how these compounds serve in cancer treatment together with their pharmacological mechanisms and it describes how novel drug delivery systems boost their therapeutic potential and bioavailability. Drug-testing evidence as well as patent documentation reveals increasing attention toward these drug compounds in cancer treatment. The three compounds paclitaxel, naringenin, and quercetin show great potential as cancer treatment and prevention agents while researchers continue to develop their clinical performance advanced through ongoing studies.

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来源期刊
Assay and drug development technologies
Assay and drug development technologies 医学-生化研究方法
CiteScore
3.60
自引率
0.00%
发文量
33
审稿时长
>12 weeks
期刊介绍: ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts
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