衰老和年龄相关疾病中的线粒体功能障碍。

IF 6.9 2区医学 Q1 GERIATRICS & GERONTOLOGY

Aging and Disease Pub Date : 2025-07-31 DOI:10.14336/AD.2025.10731

Aida Adlimoghaddam

{"title":"衰老和年龄相关疾病中的线粒体功能障碍。","authors":"Aida Adlimoghaddam","doi":"10.14336/AD.2025.10731","DOIUrl":null,"url":null,"abstract":"Mitochondrial dysfunction is increasingly recognized as a unifying mechanism underlying aging and a wide range of age-related diseases. This special issue brings together recent advances that elucidate how impaired mitochondrial function contributes to neurodegenerative, cardiovascular, and metabolic disorders. The featured articles highlight molecular pathways of mitochondrial decline, its systemic consequences, and potential interventions aimed at restoring mitochondrial health. Collectively, these studies reinforce the concept that targeting mitochondrial integrity holds significant promise for promoting healthy aging and preventing chronic disease.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":"16 5","pages":"2495-2497"},"PeriodicalIF":6.9000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339137/pdf/","citationCount":"0","resultStr":"{\"title\":\"Mitochondrial Dysfunction in Aging and Age-related Disorders.\",\"authors\":\"Aida Adlimoghaddam\",\"doi\":\"10.14336/AD.2025.10731\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Mitochondrial dysfunction is increasingly recognized as a unifying mechanism underlying aging and a wide range of age-related diseases. This special issue brings together recent advances that elucidate how impaired mitochondrial function contributes to neurodegenerative, cardiovascular, and metabolic disorders. The featured articles highlight molecular pathways of mitochondrial decline, its systemic consequences, and potential interventions aimed at restoring mitochondrial health. Collectively, these studies reinforce the concept that targeting mitochondrial integrity holds significant promise for promoting healthy aging and preventing chronic disease.\",\"PeriodicalId\":7434,\"journal\":{\"name\":\"Aging and Disease\",\"volume\":\"16 5\",\"pages\":\"2495-2497\"},\"PeriodicalIF\":6.9000,\"publicationDate\":\"2025-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12339137/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.14336/AD.2025.10731\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14336/AD.2025.10731","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

线粒体功能障碍越来越被认为是衰老和各种年龄相关疾病的统一机制。本期特刊汇集了阐明线粒体功能受损如何导致神经退行性疾病、心血管疾病和代谢疾病的最新进展。特色文章强调线粒体衰退的分子途径，其系统性后果，以及旨在恢复线粒体健康的潜在干预措施。总的来说，这些研究强化了靶向线粒体完整性对于促进健康衰老和预防慢性疾病具有重大希望的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Mitochondrial Dysfunction in Aging and Age-related Disorders.

Mitochondrial dysfunction is increasingly recognized as a unifying mechanism underlying aging and a wide range of age-related diseases. This special issue brings together recent advances that elucidate how impaired mitochondrial function contributes to neurodegenerative, cardiovascular, and metabolic disorders. The featured articles highlight molecular pathways of mitochondrial decline, its systemic consequences, and potential interventions aimed at restoring mitochondrial health. Collectively, these studies reinforce the concept that targeting mitochondrial integrity holds significant promise for promoting healthy aging and preventing chronic disease.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Aging and Disease GERIATRICS & GERONTOLOGY-

CiteScore

14.60

自引率

2.70%

发文量

138

审稿时长

10 weeks

期刊介绍： Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.