Gian Eugenio Tontini, Cristiano Spada, Peter Uebel, Renato Cannizzaro, Giorgio Ciprandi, Maurizio Vecchi
{"title":"对接受甘露醇肠道准备用于结肠镜检查的患者报告的结果评估：满意度研究。","authors":"Gian Eugenio Tontini, Cristiano Spada, Peter Uebel, Renato Cannizzaro, Giorgio Ciprandi, Maurizio Vecchi","doi":"10.1002/jgh3.70237","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Bowel preparation for colonoscopy causes significant discomfort to patients. Large volumes, unpleasant taste, and split-dosing are the main disadvantages of most laxatives. Oral mannitol could be an attractive option because it acts quickly, requires low volumes, and has a pleasant taste.</p><p><strong>Aims: </strong>A Phase III study (SATISFACTION) compared oral mannitol with polyethylene glycol-ascorbate (PEG-ADC). This <i>post hoc</i> analysis investigated the effects on patient-reported outcomes (PROMs), mainly concerning the perception of using the preparations.</p><p><strong>Methods: </strong>The SATISFACTION Phase III study was an international, multicenter, randomized (1:1), parallel-group, endoscopist-blinded, non-inferiority trial. Taste of preparations, ease of use, and willingness to repeat the preparation with the same product were scored and assessed by the patients.</p><p><strong>Results: </strong>Bowel preparation with oral mannitol resulted in a better patient satisfaction profile for all PROMs evaluated.</p><p><strong>Conclusion: </strong>Oral mannitol for bowel preparation achieved high patient satisfaction and might be a valuable option for colonoscopy.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT04759885).</p>","PeriodicalId":45861,"journal":{"name":"JGH Open","volume":"9 8","pages":"e70237"},"PeriodicalIF":1.5000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332180/pdf/","citationCount":"0","resultStr":"{\"title\":\"Assessment of Patient-Reported Outcome Measures in Patients Undergoing Bowel Preparation With Mannitol for Colonoscopy: The SATISFACTION Study.\",\"authors\":\"Gian Eugenio Tontini, Cristiano Spada, Peter Uebel, Renato Cannizzaro, Giorgio Ciprandi, Maurizio Vecchi\",\"doi\":\"10.1002/jgh3.70237\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Bowel preparation for colonoscopy causes significant discomfort to patients. Large volumes, unpleasant taste, and split-dosing are the main disadvantages of most laxatives. Oral mannitol could be an attractive option because it acts quickly, requires low volumes, and has a pleasant taste.</p><p><strong>Aims: </strong>A Phase III study (SATISFACTION) compared oral mannitol with polyethylene glycol-ascorbate (PEG-ADC). This <i>post hoc</i> analysis investigated the effects on patient-reported outcomes (PROMs), mainly concerning the perception of using the preparations.</p><p><strong>Methods: </strong>The SATISFACTION Phase III study was an international, multicenter, randomized (1:1), parallel-group, endoscopist-blinded, non-inferiority trial. Taste of preparations, ease of use, and willingness to repeat the preparation with the same product were scored and assessed by the patients.</p><p><strong>Results: </strong>Bowel preparation with oral mannitol resulted in a better patient satisfaction profile for all PROMs evaluated.</p><p><strong>Conclusion: </strong>Oral mannitol for bowel preparation achieved high patient satisfaction and might be a valuable option for colonoscopy.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT04759885).</p>\",\"PeriodicalId\":45861,\"journal\":{\"name\":\"JGH Open\",\"volume\":\"9 8\",\"pages\":\"e70237\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332180/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JGH Open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/jgh3.70237\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JGH Open","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/jgh3.70237","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Assessment of Patient-Reported Outcome Measures in Patients Undergoing Bowel Preparation With Mannitol for Colonoscopy: The SATISFACTION Study.
Background: Bowel preparation for colonoscopy causes significant discomfort to patients. Large volumes, unpleasant taste, and split-dosing are the main disadvantages of most laxatives. Oral mannitol could be an attractive option because it acts quickly, requires low volumes, and has a pleasant taste.
Aims: A Phase III study (SATISFACTION) compared oral mannitol with polyethylene glycol-ascorbate (PEG-ADC). This post hoc analysis investigated the effects on patient-reported outcomes (PROMs), mainly concerning the perception of using the preparations.
Methods: The SATISFACTION Phase III study was an international, multicenter, randomized (1:1), parallel-group, endoscopist-blinded, non-inferiority trial. Taste of preparations, ease of use, and willingness to repeat the preparation with the same product were scored and assessed by the patients.
Results: Bowel preparation with oral mannitol resulted in a better patient satisfaction profile for all PROMs evaluated.
Conclusion: Oral mannitol for bowel preparation achieved high patient satisfaction and might be a valuable option for colonoscopy.
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