Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Salem M Tos, Mohammad Amin Habibi, Rana Hashemi, Arman Hasanzade, Azin Ebrahimi, Kimia Didehvar, Mahdi Hooshmand, Sara Bana
{"title":"p48分流器治疗颅内动脉瘤的疗效和安全性：一项系统综述和meta分析。","authors":"Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Salem M Tos, Mohammad Amin Habibi, Rana Hashemi, Arman Hasanzade, Azin Ebrahimi, Kimia Didehvar, Mahdi Hooshmand, Sara Bana","doi":"10.1007/s00234-025-03737-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The p48 movable wire (MW) flow modulation devices are a group of novel low-profile flow diverters (FDs) that have recently been introduced for the management of small intracranial aneurysms (IAs). This study evaluates the current literature regarding the efficacy and safety of p48 in treating IAs.</p><p><strong>Methods: </strong>A literature search was conducted using the PubMed, Embase, Scopus, and Web of Science databases. Studies evaluating the role of p48 FDs in IAs were included.</p><p><strong>Results: </strong>Twelve studies encompassing 312 individuals with 330 IAs were included. The meta-analysis revealed a pooled complete occlusion rate of 58% (95% CI: 40%-75%), a favorable outcome rate of 96% (95% CI: 86%-100%), and a morbidity rate of 1% (95% CI: 0%-3%). Regarding the complications, our findings showed a pooled intraprocedural rate of 7% (95% CI: 1%-16%), a postprocedural rate of 9% (95% CI: 6%-13%), an ischemic complication rate of 8% (95% CI: 5%-12%), a hemorrhagic complication rate of 3% (95% CI: 1%-5%), and an in-stent stenosis rate of 1% (95% CI: 0%-3%). The subgroup analysis comparing p48 MW and p48 MW with a hydrophilic coating (HPC) did not demonstrate significant differences between groups in outcomes and complications, except for hemorrhagic complications, which were higher in p48 MW than in p48 MW HPC devices (p48: 3% vs. p48 HPC: 0%, P = 0.04).</p><p><strong>Conclusion: </strong>The p48 FDs represent novel therapeutic options in the management of IAs, associated with promising outcomes and low complication rates.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy and safety of p48 flow diverters in the treatment of intracranial aneurysms: A systematic review and Meta-Analysis.\",\"authors\":\"Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Salem M Tos, Mohammad Amin Habibi, Rana Hashemi, Arman Hasanzade, Azin Ebrahimi, Kimia Didehvar, Mahdi Hooshmand, Sara Bana\",\"doi\":\"10.1007/s00234-025-03737-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The p48 movable wire (MW) flow modulation devices are a group of novel low-profile flow diverters (FDs) that have recently been introduced for the management of small intracranial aneurysms (IAs). This study evaluates the current literature regarding the efficacy and safety of p48 in treating IAs.</p><p><strong>Methods: </strong>A literature search was conducted using the PubMed, Embase, Scopus, and Web of Science databases. Studies evaluating the role of p48 FDs in IAs were included.</p><p><strong>Results: </strong>Twelve studies encompassing 312 individuals with 330 IAs were included. The meta-analysis revealed a pooled complete occlusion rate of 58% (95% CI: 40%-75%), a favorable outcome rate of 96% (95% CI: 86%-100%), and a morbidity rate of 1% (95% CI: 0%-3%). Regarding the complications, our findings showed a pooled intraprocedural rate of 7% (95% CI: 1%-16%), a postprocedural rate of 9% (95% CI: 6%-13%), an ischemic complication rate of 8% (95% CI: 5%-12%), a hemorrhagic complication rate of 3% (95% CI: 1%-5%), and an in-stent stenosis rate of 1% (95% CI: 0%-3%). The subgroup analysis comparing p48 MW and p48 MW with a hydrophilic coating (HPC) did not demonstrate significant differences between groups in outcomes and complications, except for hemorrhagic complications, which were higher in p48 MW than in p48 MW HPC devices (p48: 3% vs. p48 HPC: 0%, P = 0.04).</p><p><strong>Conclusion: </strong>The p48 FDs represent novel therapeutic options in the management of IAs, associated with promising outcomes and low complication rates.</p>\",\"PeriodicalId\":19422,\"journal\":{\"name\":\"Neuroradiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-08-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroradiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00234-025-03737-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00234-025-03737-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Efficacy and safety of p48 flow diverters in the treatment of intracranial aneurysms: A systematic review and Meta-Analysis.
Background: The p48 movable wire (MW) flow modulation devices are a group of novel low-profile flow diverters (FDs) that have recently been introduced for the management of small intracranial aneurysms (IAs). This study evaluates the current literature regarding the efficacy and safety of p48 in treating IAs.
Methods: A literature search was conducted using the PubMed, Embase, Scopus, and Web of Science databases. Studies evaluating the role of p48 FDs in IAs were included.
Results: Twelve studies encompassing 312 individuals with 330 IAs were included. The meta-analysis revealed a pooled complete occlusion rate of 58% (95% CI: 40%-75%), a favorable outcome rate of 96% (95% CI: 86%-100%), and a morbidity rate of 1% (95% CI: 0%-3%). Regarding the complications, our findings showed a pooled intraprocedural rate of 7% (95% CI: 1%-16%), a postprocedural rate of 9% (95% CI: 6%-13%), an ischemic complication rate of 8% (95% CI: 5%-12%), a hemorrhagic complication rate of 3% (95% CI: 1%-5%), and an in-stent stenosis rate of 1% (95% CI: 0%-3%). The subgroup analysis comparing p48 MW and p48 MW with a hydrophilic coating (HPC) did not demonstrate significant differences between groups in outcomes and complications, except for hemorrhagic complications, which were higher in p48 MW than in p48 MW HPC devices (p48: 3% vs. p48 HPC: 0%, P = 0.04).
Conclusion: The p48 FDs represent novel therapeutic options in the management of IAs, associated with promising outcomes and low complication rates.
期刊介绍：
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
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