{"title":"移植失败与约旦肾移植受者BK病毒血症状态的关系","authors":"Rabaa Y Athamneh, Reema Bani Saeed, Omaymah Abulannaz, Rawan Abudalo, Muna Oqal","doi":"10.18502/ijm.v17i4.19256","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>BK polyomavirus (BKPyV) poses a significant threat to kidney transplant (KT) recipients due to immunosuppression, leading to BK-associated nephropathy (BKVN) and reduced transplant survival. This study aimed to determine the prevalence of BKPyV among kidney transplant recipients in Jordan and to evaluate the association between BKPyV activity and kidney transplant outcomes.</p><p><strong>Materials and methods: </strong>A retrospective observational study was conducted at the Jordanian Royal Medical Services Hospital (JRMS) from 2021 to 2024. Blood samples (n=157) from kidney transplant recipients were collected, and quantitative real-time PCR was performed to detect BKPyV DNA.</p><p><strong>Results: </strong>The prevalence of BKPyV infection among kidney transplant recipients was 40.8% (n=64). Transplant failure occurred in 36% of cases (n=57), with BKPyV-DNA viremia observed in 74% of those with transplant failure (n=42). The prevalence of infection was significantly higher in patients under 18 years of age (81%, p<0.001) and in males (72%, p<0.001). BKPyV infection increased the odds of transplant failure tenfold.</p><p><strong>Conclusion: </strong>In Jordan, the prevalence of BKPyV among kidney transplant recipients is high, particularly in males and younger patients. BKPyV significantly increases the risk of kidney transplant failure. Other studies are needed to further elucidate the impact of BKPyV on kidney transplant rejection and complications.</p>","PeriodicalId":14633,"journal":{"name":"Iranian Journal of Microbiology","volume":"17 4","pages":"629-635"},"PeriodicalIF":1.7000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331449/pdf/","citationCount":"0","resultStr":"{\"title\":\"Transplant failure in relation to BK viremia status among kidney transplant recipients in Jordan.\",\"authors\":\"Rabaa Y Athamneh, Reema Bani Saeed, Omaymah Abulannaz, Rawan Abudalo, Muna Oqal\",\"doi\":\"10.18502/ijm.v17i4.19256\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>BK polyomavirus (BKPyV) poses a significant threat to kidney transplant (KT) recipients due to immunosuppression, leading to BK-associated nephropathy (BKVN) and reduced transplant survival. This study aimed to determine the prevalence of BKPyV among kidney transplant recipients in Jordan and to evaluate the association between BKPyV activity and kidney transplant outcomes.</p><p><strong>Materials and methods: </strong>A retrospective observational study was conducted at the Jordanian Royal Medical Services Hospital (JRMS) from 2021 to 2024. Blood samples (n=157) from kidney transplant recipients were collected, and quantitative real-time PCR was performed to detect BKPyV DNA.</p><p><strong>Results: </strong>The prevalence of BKPyV infection among kidney transplant recipients was 40.8% (n=64). Transplant failure occurred in 36% of cases (n=57), with BKPyV-DNA viremia observed in 74% of those with transplant failure (n=42). The prevalence of infection was significantly higher in patients under 18 years of age (81%, p<0.001) and in males (72%, p<0.001). BKPyV infection increased the odds of transplant failure tenfold.</p><p><strong>Conclusion: </strong>In Jordan, the prevalence of BKPyV among kidney transplant recipients is high, particularly in males and younger patients. BKPyV significantly increases the risk of kidney transplant failure. Other studies are needed to further elucidate the impact of BKPyV on kidney transplant rejection and complications.</p>\",\"PeriodicalId\":14633,\"journal\":{\"name\":\"Iranian Journal of Microbiology\",\"volume\":\"17 4\",\"pages\":\"629-635\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331449/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18502/ijm.v17i4.19256\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/ijm.v17i4.19256","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Transplant failure in relation to BK viremia status among kidney transplant recipients in Jordan.
Background and objectives: BK polyomavirus (BKPyV) poses a significant threat to kidney transplant (KT) recipients due to immunosuppression, leading to BK-associated nephropathy (BKVN) and reduced transplant survival. This study aimed to determine the prevalence of BKPyV among kidney transplant recipients in Jordan and to evaluate the association between BKPyV activity and kidney transplant outcomes.
Materials and methods: A retrospective observational study was conducted at the Jordanian Royal Medical Services Hospital (JRMS) from 2021 to 2024. Blood samples (n=157) from kidney transplant recipients were collected, and quantitative real-time PCR was performed to detect BKPyV DNA.
Results: The prevalence of BKPyV infection among kidney transplant recipients was 40.8% (n=64). Transplant failure occurred in 36% of cases (n=57), with BKPyV-DNA viremia observed in 74% of those with transplant failure (n=42). The prevalence of infection was significantly higher in patients under 18 years of age (81%, p<0.001) and in males (72%, p<0.001). BKPyV infection increased the odds of transplant failure tenfold.
Conclusion: In Jordan, the prevalence of BKPyV among kidney transplant recipients is high, particularly in males and younger patients. BKPyV significantly increases the risk of kidney transplant failure. Other studies are needed to further elucidate the impact of BKPyV on kidney transplant rejection and complications.
期刊介绍：
The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.
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