{"title":"TOR信号介导果蝇卵发生中边界细胞的集体运动。","authors":"Sudipta Halder, Adhisree Sharma, Sayan Acharjee, Neha Biju, Mincy Kunjumon, Rohan Jayant Khadilkar, Mohit Prasad","doi":"10.1242/dev.204612","DOIUrl":null,"url":null,"abstract":"<p><p>Collective cell migration is seen in various biological processes spanning embryonic development, organogenesis, wound healing and, unfortunately, cancer metastasis. Here, we have examined the role of the evolutionarily conserved Target of Rapamycin signalling (TOR) in mediating collective cell movement employing the model of migrating border cells (BCs) in Drosophila oogenesis. Although TOR signalling is classically linked to cell growth, cell proliferation and metabolism, here we demonstrate that TOR complex 1 (TORC1) regulates efficient group cell movement of BCs. Employing live cell imaging, genetics, and tissue immunohistochemistry, we demonstrate that TOR functions through the transcription factor REPTOR to modulate Death-associated inhibitor of apoptosis 1 (Diap1) in mediating efficient movement of BCs. Coincidentally, rapamycin-treated myeloblast Kasumi-1 cells exhibit lower levels of transcript for the Diap1 homologue baculoviral IAP repeat-containing 2 (BIRC2), similar to what is observed in flies.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448311/pdf/","citationCount":"0","resultStr":"{\"title\":\"TOR signalling mediates the collective movement of border cells in Drosophila oogenesis.\",\"authors\":\"Sudipta Halder, Adhisree Sharma, Sayan Acharjee, Neha Biju, Mincy Kunjumon, Rohan Jayant Khadilkar, Mohit Prasad\",\"doi\":\"10.1242/dev.204612\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Collective cell migration is seen in various biological processes spanning embryonic development, organogenesis, wound healing and, unfortunately, cancer metastasis. Here, we have examined the role of the evolutionarily conserved Target of Rapamycin signalling (TOR) in mediating collective cell movement employing the model of migrating border cells (BCs) in Drosophila oogenesis. Although TOR signalling is classically linked to cell growth, cell proliferation and metabolism, here we demonstrate that TOR complex 1 (TORC1) regulates efficient group cell movement of BCs. Employing live cell imaging, genetics, and tissue immunohistochemistry, we demonstrate that TOR functions through the transcription factor REPTOR to modulate Death-associated inhibitor of apoptosis 1 (Diap1) in mediating efficient movement of BCs. Coincidentally, rapamycin-treated myeloblast Kasumi-1 cells exhibit lower levels of transcript for the Diap1 homologue baculoviral IAP repeat-containing 2 (BIRC2), similar to what is observed in flies.</p>\",\"PeriodicalId\":11375,\"journal\":{\"name\":\"Development\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448311/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Development\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1242/dev.204612\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Development","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1242/dev.204612","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
TOR signalling mediates the collective movement of border cells in Drosophila oogenesis.
Collective cell migration is seen in various biological processes spanning embryonic development, organogenesis, wound healing and, unfortunately, cancer metastasis. Here, we have examined the role of the evolutionarily conserved Target of Rapamycin signalling (TOR) in mediating collective cell movement employing the model of migrating border cells (BCs) in Drosophila oogenesis. Although TOR signalling is classically linked to cell growth, cell proliferation and metabolism, here we demonstrate that TOR complex 1 (TORC1) regulates efficient group cell movement of BCs. Employing live cell imaging, genetics, and tissue immunohistochemistry, we demonstrate that TOR functions through the transcription factor REPTOR to modulate Death-associated inhibitor of apoptosis 1 (Diap1) in mediating efficient movement of BCs. Coincidentally, rapamycin-treated myeloblast Kasumi-1 cells exhibit lower levels of transcript for the Diap1 homologue baculoviral IAP repeat-containing 2 (BIRC2), similar to what is observed in flies.
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Development’s scope covers all aspects of plant and animal development, including stem cell biology and regeneration. The single most important criterion for acceptance in Development is scientific excellence. Research papers (articles and reports) should therefore pose and test a significant hypothesis or address a significant question, and should provide novel perspectives that advance our understanding of development. We also encourage submission of papers that use computational methods or mathematical models to obtain significant new insights into developmental biology topics. Manuscripts that are descriptive in nature will be considered only when they lay important groundwork for a field and/or provide novel resources for understanding developmental processes of broad interest to the community.
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