成人短肠综合征引起的慢性肠衰竭的发生率：一项可行性研究。

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-08-08 DOI:10.1016/j.clnesp.2025.08.009

Loris Pironi , Federica Sacilotto , Anna Simona Sasdelli , Carlotta Cavoli , Mariacristina Guidetti , Gentilini Lorenzo , Claudio Ricci , Riccardo Casadei , Gilberto Poggioli

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引用次数: 0

摘要

背景：短肠综合征相关慢性肠衰竭（SBS-CIF）的发生率是完全未知的。在博洛尼亚大学（意大利）的三级医院进行了可行性研究，以检验为调查SBS-CIF在医院和人口发病率而设计的议定书。方法：对该院两个消化内科外科进行为期3个月（2024年1 - 3月）的回顾性调查。患者纳入标准为：年龄≥18岁，住院前腹部手术伴小肠切除和无家庭肠外营养（HPN）。排除标准：入院时已在使用HPN的患者。“SBS-CIF”的诊断标准是纳入研究后3个月内患者按HPN出院（随访结束，2024年6月30日）。住院3个月的发病率和人口发病率分别以接受腹部手术并进行小肠切除术的患者的百分比和发生SBS-CIF的患者的百分比以及博洛尼亚大都会区每百万居民的“SBS-CIF”计算。结果：67例患者符合纳入标准。截至6月30日，无HPN出院56例（83.5%），住院期间死亡5例，有HPN出院6例（院内发病率SBS-CIF: 8.9%）。2例居住在博洛尼亚大都会区（SBS-CIF发病率：1.96例/106名居民）。结论：我们的研究提出了一个调查成人SBS-CIF发病率的模型。该结果为迄今为止尚未开发的SBS-CIF流行病学领域提供了新的数据，重要的是为在国家和国际范围内进一步研究SBS-CIF流行病学提供了一个多中心研究模型。

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Incidence of chronic intestinal failure due short bowel syndrome in adults: A feasibility study

Background

The incidence of short bowel syndrome associated chronic intestinal failure (SBS-CIF) is entirely unknown. A feasibility study was carried out in the tertiary-level hospital of the Bologna University (Italy), to test a protocol devised to investigate the in-hospital and the population incidences of SBS-CIF.

Methods

A 3-month (January–March 2024) retrospective survey was carried out in the two digestive disease surgical units of the hospital. Patient inclusion criteria were: age ≥18 years, abdominal surgery with small bowel resection and no-home parenteral nutrition (HPN) before hospital admission. Exclusion criterion: patient already on HPN at hospital admission. Criterion for the diagnosis of “SBS-CIF” was patient discharge on HPN within 3 months from inclusion of the study (end of the follow-up, June 30th 2024).

The 3-month in-hospital and population incidences were calculated as percentage of patients who underwent abdominal surgery with a small bowel resection procedure and who developed SBS-CIF, and as “SBS-CIF” per million of inhabitants of the Bologna metropolitan area, respectivelyy.

Results

Sixty-seven patients met the inclusion criteria. At June 30th, 56 patients were discharged without HPN (83.5 %), 5 died during hospitalization, 6 were discharged on HPN (in-hospital incidence SBS-CIF: 8.9 %). Two SBS-CIF were resident in the Bologna metropolitan area (SBS-CIF incidence: 1.96 cases/10⁶ inhabitants).

Conclusions

Our study proposes a model to investigate the incidence of SBS-CIF in adults. The results provide new data on this hitherto unexplored area of SBS-CIF epidemiology and, importantly, offer a model for multicenter studies to further investigate the epidemiology of SBS-CIF on a national and international scale.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.