Majid Saraei Koushki, Razieh Parizad, Ali Abdollahzadeh, Ahmad Separham
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引用次数: 0
摘要
背景：糖化血红蛋白（HbA1c）水平与心血管疾病（cvd）和死亡的增加有关，即使在非糖尿病受试者中也是如此。尽管在st段抬高型心肌梗死（STEMI）病例中，HbA1c与冠状动脉疾病（CAD）之间的关系尚不清楚。方法：本横断面研究对167例非糖尿病STEMI患者进行了经皮冠状动脉介入治疗（PCI）。SYNTAX评分用于评估CAD的严重程度。根据HbA1c水平将病例分为三组：结果：与其他组相比，HbA1c水平为6至6.5的患者SYNTAX评分显著升高（28.9±9.5 vs 21.2±5.2 vs 13.7±4.5，P=0.000）。此外，该组的死亡率更高（4% vs 0% vs 0%， P=0.006）。结论：在非糖尿病STEMI患者中，较高的HbA1c水平与冠状动脉粥样硬化密切相关。因此，在非糖尿病STEMI患者中，HbA1c可能能够预测CAD的严重程度。
Impact of HbA1c levels on coronary SYNTAX score in non-diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A cross-sectional study.
Background: Glycated hemoglobin A1c (HbA1c) level is related to increased cardiovascular diseases (CVDs) and death, even in non-diabetic subjects. Although in ST-elevation myocardial infarction (STEMI) cases, the association between HbA1c and coronary artery disease (CAD) remains unclear.
Methods: This cross-sectional study was conducted on 167 non-diabetic STEMI patients undergoing primary percutaneous coronary intervention (PCI). The SYNTAX score was utilized to evaluate CAD severity. Cases were categorized into three groups based on the HbA1c levels: <5%, 5.1-5.9%, and 6-6.5%.
Results: SYNTAX scores significantly increased in the cases with 6 to 6.5 HbA1c levels compared to the other group (28.9±9.5 vs 21.2±5.2 vs 13.7±4.5, P=0.000). Additionally, death was more elevated in this group (4% vs 0% vs 0%, P=0.006).
Conclusion: Higher HbA1c levels are strongly associated with coronary atherosclerosis in non-diabetic patients that present with non-diabetic STEMI. Consequently, in non-diabetic STEMI patients, HbA1c may be able to predict the severity of CAD.
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