Antoine Symoens, Marie-Lou Gauthier, Louise Paillette, Marion Allano, Jean-Pierre Lavoie, Mathilde Leclère
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Data were analyzed with <i>X</i> <i><sup>2</sup></i> tests for trends, followed by pairwise Fisher tests and Bonferroni corrections.</p><p><strong>Results: </strong>Increasing resistance to at least 1 antibiotic was observed for 5 of the 6 bacteria studied, including increasing resistance to enrofloxacin for <i>Escherichia coli, Pseudomonas</i> spp., <i>Enterobacter</i> spp., and staphylococci, and to ceftiofur for <i>Enterobacter</i> spp. and staphylococci. Resistance of <i>Actinobacillus</i> spp. to ampicillin and penicillin decreased over time, whereas resistance of <i>Streptococcus equi</i> subsp. <i>zooepidemicus</i> to penicillin was not observed.</p><p><strong>Conclusion and clinical relevance: </strong>Bacteria isolated from horses had increasing resistance to antibiotic classes considered critically important for human health. However, penicillin remained an appropriate 1st-line antibiotic for <i>Actinobacillus</i> spp. and <i>Streptococcus equi</i> subsp. <i>zooepidemicus</i> in our area.</p>","PeriodicalId":9429,"journal":{"name":"Canadian Veterinary Journal-revue Veterinaire Canadienne","volume":"66 8","pages":"903-910"},"PeriodicalIF":1.0000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330761/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evolution of <i>in vitro</i> antimicrobial resistance at an equine hospital over 4 decades.\",\"authors\":\"Antoine Symoens, Marie-Lou Gauthier, Louise Paillette, Marion Allano, Jean-Pierre Lavoie, Mathilde Leclère\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to document antimicrobial resistance patterns of bacteria frequently isolated at a referral equine hospital between 2020 and 2022 and to compare these results to those of studies carried out in previous decades at the same reference center.</p><p><strong>Procedure: </strong>Using the Kirby-Bauer method, 340 tests were completed on bacterial isolates and compared to 233, 255, and 396 tests carried out in 1986 to 1988, 1996 to 1998, and 2007 to 2013, respectively. Data were analyzed with <i>X</i> <i><sup>2</sup></i> tests for trends, followed by pairwise Fisher tests and Bonferroni corrections.</p><p><strong>Results: </strong>Increasing resistance to at least 1 antibiotic was observed for 5 of the 6 bacteria studied, including increasing resistance to enrofloxacin for <i>Escherichia coli, Pseudomonas</i> spp., <i>Enterobacter</i> spp., and staphylococci, and to ceftiofur for <i>Enterobacter</i> spp. and staphylococci. Resistance of <i>Actinobacillus</i> spp. to ampicillin and penicillin decreased over time, whereas resistance of <i>Streptococcus equi</i> subsp. <i>zooepidemicus</i> to penicillin was not observed.</p><p><strong>Conclusion and clinical relevance: </strong>Bacteria isolated from horses had increasing resistance to antibiotic classes considered critically important for human health. However, penicillin remained an appropriate 1st-line antibiotic for <i>Actinobacillus</i> spp. and <i>Streptococcus equi</i> subsp. <i>zooepidemicus</i> in our area.</p>\",\"PeriodicalId\":9429,\"journal\":{\"name\":\"Canadian Veterinary Journal-revue Veterinaire Canadienne\",\"volume\":\"66 8\",\"pages\":\"903-910\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330761/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian Veterinary Journal-revue Veterinaire Canadienne\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian Veterinary Journal-revue Veterinaire Canadienne","FirstCategoryId":"97","ListUrlMain":"","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Evolution of in vitro antimicrobial resistance at an equine hospital over 4 decades.
Objective: This study aimed to document antimicrobial resistance patterns of bacteria frequently isolated at a referral equine hospital between 2020 and 2022 and to compare these results to those of studies carried out in previous decades at the same reference center.
Procedure: Using the Kirby-Bauer method, 340 tests were completed on bacterial isolates and compared to 233, 255, and 396 tests carried out in 1986 to 1988, 1996 to 1998, and 2007 to 2013, respectively. Data were analyzed with X2 tests for trends, followed by pairwise Fisher tests and Bonferroni corrections.
Results: Increasing resistance to at least 1 antibiotic was observed for 5 of the 6 bacteria studied, including increasing resistance to enrofloxacin for Escherichia coli, Pseudomonas spp., Enterobacter spp., and staphylococci, and to ceftiofur for Enterobacter spp. and staphylococci. Resistance of Actinobacillus spp. to ampicillin and penicillin decreased over time, whereas resistance of Streptococcus equi subsp. zooepidemicus to penicillin was not observed.
Conclusion and clinical relevance: Bacteria isolated from horses had increasing resistance to antibiotic classes considered critically important for human health. However, penicillin remained an appropriate 1st-line antibiotic for Actinobacillus spp. and Streptococcus equi subsp. zooepidemicus in our area.
期刊介绍：
The Canadian Veterinary Journal (CVJ) provides a forum for the discussion of all matters relevant to the veterinary profession. The mission of the Journal is to educate by informing readers of progress in clinical veterinary medicine, clinical veterinary research, and related fields of endeavor. The key objective of The CVJ is to promote the art and science of veterinary medicine and the betterment of animal health.
A report suggesting that animals have been unnecessarily subjected to adverse, stressful, or harsh conditions or treatments will not be processed for publication. Experimental studies using animals will only be considered for publication if the studies have been approved by an institutional animal care committee, or equivalent, and the guidelines of the Canadian Council on Animal Care, or equivalent, have been followed by the author(s).
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