P2Y6R在癌症及其拮抗剂中的作用。

IF 7.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-08-08 DOI:10.1016/j.drudis.2025.104449

Xin Wang , Jiliang Zhang , Yongtao Duan , Chuanjun Song

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引用次数: 0

摘要

P2Y嘌呤受体6 （P2Y6R）是近年来获得广泛研究关注的靶点，与多种疾病有关。具体而言，P2Y6R在多种肿瘤组织和细胞中均有异常高表达，并与肿瘤的恶性程度和转移密切相关。P2Y6R拮抗剂已被证明能有效阻断促进肿瘤生长的信号通路，从而抑制癌细胞的增殖、迁移和侵袭。这些发现表明，靶向P2Y6R是一种很有前景的癌症治疗策略。本文就P2Y6R在肿瘤中的作用、抗癌机制及相关拮抗剂的研究进展进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of P2Y6R in cancer and its antagonists

P2Y₆R, a target that has garnered extensive research attention in recent years, has been implicated in a diverse range of diseases. Specifically, abnormally high expression levels of P2Y₆R have been identified in various tumor tissues and cells and are closely associated with the degree of malignancy and metastasis of the tumor. Antagonists against P2Y₆R have been shown to effectively block signaling pathways that promote tumor growth, thereby inhibiting cancer cell proliferation, migration, and invasion. These findings suggest that targeting P2Y₆R is a promising strategy for cancer treatment. This review summarizes the role of P2Y₆R in cancer, the anticancer mechanisms, and research progress related to the antagonists.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.