淋巴细胞分数作为炎性肠病t -辅助性1/ t -辅助性2细胞因子谱的指标

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-08-11 DOI:10.1002/jgh3.70243

Yusuke Asai, Natsuki Ishida, Tomohiro Takebe, Kenichi Takahashi, Tomoharu Matsuura, Satoshi Tamura, Mihoko Yamade, Takanori Yamada, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Ken Sugimoto

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引用次数: 0

摘要

目的炎症性肠病以多种细胞因子模式为特征。在本研究中，我们旨在研究炎症性肠病患者中可以区分Th1/Th2细胞因子的标志物。方法与结果在我院治疗的炎症性肠病患者中，同时测定血清中Th1/Th2比值（干扰素-γ/白细胞介素-4比值）、血清免疫球蛋白E水平、富亮氨酸- α - 2糖蛋白水平、血清淀粉样蛋白A水平、白细胞分数，并探讨它们之间的关系。我们招募了108名克罗恩病患者和153名溃疡性结肠炎患者。溃疡性结肠炎组和克罗恩病组之间Th1/Th2比值无显著差异。炎症性肠病组和克罗恩病组淋巴细胞分数与Th1/Th2比值显著相关（r = 0.154, p = 0.013和r = 0.204, p = 0.0346）。在溃疡性结肠炎中，未使用类固醇治疗组淋巴细胞分数和Th1/Th2比值显著相关；然而，在类固醇治疗组中没有观察到显著的相关性。血清免疫球蛋白E、富含亮氨酸的α - 2糖蛋白和血清淀粉样蛋白A水平与Th1/Th2比值无显著相关性。结论淋巴细胞分数可作为Th1/Th2细胞因子的标志物，在非类固醇治疗的患者中可能特别有用。

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Lymphocyte Fractions as Indicators of T-Helper 1/T-Helper 2 Cytokine Profiles in Inflammatory Bowel Disease

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Lymphocyte Fractions as Indicators of T-Helper 1/T-Helper 2 Cytokine Profiles in Inflammatory Bowel Disease

Aims

Inflammatory bowel disease is characterized by various cytokine patterns. In this study, we aimed to investigate the markers that can distinguish Th1/Th2 cytokines in patients with inflammatory bowel disease.

Methods and Results

In patients with inflammatory bowel disease treated at our hospital, the Th1/Th2 ratio (interferon-γ/interleukin-4 ratio), serum immunoglobulin E level, leucine-rich alpha 2 glycoprotein level, serum amyloid A level, and leukocyte fraction were measured simultaneously, and the relationship between them was examined. We enrolled 108 patients with Crohn's disease and 153 patients with ulcerative colitis. No significant difference was observed in the Th1/Th2 ratio between the ulcerative colitis and Crohn's disease groups. In the inflammatory bowel disease and Crohn's disease groups, the lymphocyte fraction was significantly correlated with the Th1/Th2 ratio (r = 0.154, p = 0.013 and r = 0.204, p = 0.0346, respectively). In ulcerative colitis, lymphocyte fraction and Th1/Th2 ratio were significantly correlated in the group without steroid treatment; however, no significant correlation was observed in the steroid-treated group. Serum immunoglobulin E, leucine-rich alpha 2 glycoproteins, and serum amyloid A levels did not significantly correlate with the Th1/Th2 ratio.