具有抗癌活性的埃塞俄比亚菟丝子新三萜类化合物

IF 4.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-07-30 DOI:10.1021/acsomega.5c03203

Taame G. Seyoum, Zhenming Du*, Siming Wang, Wen Lu, Qiyue Mao, Xiaoxiao Yang, Aman Dekebo, Ermias Dagne, Paulos Yohannes* and Binghe Wang,

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引用次数: 0

摘要

从产自非洲埃塞俄比亚的木蕨树脂中分离得到3个新的三萜类化合物，分别为tirucalla-7,24-二烯-1β，3β-二醇（oddurensinoid B）， tirucalla-7-烯-1β，3β，25-三醇（oddurensinoid H）和tirucalla-7,24-二烯-3β-醇-1- o -β-d-葡萄糖吡喃苷（oddurensinoid K）。通过一维核磁共振（1D）、二维核磁共振（2D）和高分辨率质谱（HRMS）对其结构进行了鉴定。这三种化合物对HeLa细胞系的抗癌活性进行了测试。它们均表现出抗癌活性，其中以oddurensinoid H最强，IC50值为0.017 mg/mL （36.9 μM）。

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New Tirucallane-Type Triterpenes Isolated from Commiphora oddurensis from Ethiopia with Anticancer Activity

Three new tirucallane-type triterpenes, tirucalla-7,24-diene-1β,3β-diol (oddurensinoid B), tirucalla-7-ene-1β,3β,25-triol (oddurensinoid H), and tirucalla-7, 24-diene-3β-ol-1-O-β-d-glucopyranoside (oddurensinoid K), were isolated from the resin of Commiphora oddurensis harvested from Ethiopia, Africa. Their structures were elucidated by one-dimensional (1D) NMR, two-dimensional (2D) NMR, and high-resolution mass spectrometry (HRMS). All three compounds were tested for their anticancer activity against HeLa cell lines. They all exhibit anticancer activity, with oddurensinoid H the most potent with IC₅₀ of 0.017 mg/mL (36.9 μM).

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.