大量饮用咖啡可能会增加吸烟者的主动脉直径和腹主动脉瘤的风险。

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-08-09 DOI:10.1038/s41598-025-12668-2

Joanna Kaluza, Otto Stackelberg, Martin Björck, Alicja Wolk

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引用次数: 0

摘要

咖啡消费与腹主动脉瘤（AAA）风险之间的关系尚不清楚。我们假设咖啡摄入量会影响主动脉直径和AAA风险，吸烟状况是一个调节因素。该研究包括42,723名瑞典男性和34,921名女性（年龄45-83岁），测量了8,109名男性的肾下主动脉直径（IAD）。在18.7年的时间里，我们发现了1863例AAA病例（1585例未破裂，278例破裂）。在每天喝咖啡≤5杯的参与者中，当前吸烟者与从不吸烟者相比，未破裂和破裂的AAA风险高3倍（HR = 3.12, 95%CI = 2.62-3.71, HR = 2.90, 95%CI = 1.95-4.31）；每天喝50杯咖啡的风险增加，未破裂的风险增加4倍（HR = 3.89, 95%CI = 3.12-4.85），破裂的风险增加4.6倍（HR = 4.61, 95%CI = 2.72-7.86）（p值-倍增-相互作用= 0.009）。160名（2.0%）筛查男性的内径≥30 mm。在每天饮用≤3杯咖啡的男性中，当前吸烟者与从不吸烟者相比，IAD≥30 mm的风险高出4倍（OR = 4.09, 95%CI = 1.81-9.22）；在喝咖啡量较高的男性中（每天3杯），风险增加6.6倍（OR = 6.58, 95%CI = 2.98-14.6）。在戒烟者中，相应的or分别为1.67 （95%CI = 0.62-4.49）和3.27 （95%CI = 1.27-8.40）。综上所述，大量饮用咖啡可能会增加吸烟者发生AAA和肾下主动脉直径的风险。

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High coffee consumption may increase aortic diameter and risk of abdominal aortic aneurysm in smokers.

An association of coffee consumption with a risk of abdominal aortic aneurysm (AAA) is unknown. We hypothesized that coffee consumption influences aortic diameter and AAA risk, with smoking status as a modifier. The study included 42,723 Swedish men and 34,921 women (age 45-83 years) with infrarenal aortic diameter (IAD) measured in 8,109 men. Over 18.7 years, 1863 AAA cases (1585 non-ruptured, 278 ruptured) were identified. Among participants with coffee consumption ≤ 5 cups/day, current smokers versus never smokers had a 3-fold higher risk of non-ruptured and ruptured AAA (HR = 3.12, 95%CI = 2.62-3.71 and HR = 2.90, 95%CI = 1.95-4.31, respectively); the risk increased with coffee consumption > 5 cups/day and was a 4-fold higher (HR = 3.89, 95%CI = 3.12-4.85) for non-ruptured and a 4.6-fold higher (HR = 4.61, 95%CI = 2.72-7.86) for ruptured AAA (P-value- multiplicative-interaction = 0.009). 160 (2.0%) screened men had an IAD ≥ 30 mm. In men drinking daily ≤ 3 cups of coffee, current smokers versus never smokers had a 4-fold (OR = 4.09, 95%CI = 1.81-9.22) higher risk of IAD ≥ 30 mm; in men with higher coffee consumption (> 3 cups/day), the risk increased 6.6-fold (OR = 6.58, 95%CI = 2.98-14.6). In ex-smokers, the corresponding ORs were 1.67 (95%CI = 0.62-4.49) and 3.27 (95%CI = 1.27-8.40), respectively. In conclusion, high coffee consumption may increase risk of AAA and infrarenal aortic diameter in smokers.

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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