孟加拉国尼帕病毒株流行病学、临床特征和遗传多样性：2016年至2023年

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-08-07 DOI:10.1016/j.ijid.2025.108010

Syed Moinuddin Satter , Dewan Imtiaz Rahman , Sharmin Sultana , Md. Mahfuzur Rahman , Wasik Rahman Aquib , Arifa Nazneen , Anika Farzin , Kamal Ibne Amin Chowdhury , Tonmoy Sarkar , Fateha Akther Ema , Shadman Sakib Choudhury , Ayesha Siddika , Muhammad Rashedul Alam , Faruq Abdulla , Probir Kumar Ghosh , Md. Omar Qayum , Md. Ferdous Rahman Sarker , Md Abdullah Omar Nasif , Barnali Sen , Mintu Chowdhury , Tahmina Shirin

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引用次数: 0

摘要

背景：尼帕病毒（NiV）在孟加拉国引起致命疫情，致死率为71%。两个亚系，niv - bd1和niv - bd2已被确定。本研究的目的是表征其流行病学和临床多样性。方法：本研究分析了21个新报道的（2016-2023）和17个先前报道的（2012-2015）NiV基因组序列，并使用描述性和双变量分析比较了亚谱系。结果：测序病例的中位年龄为17岁（IQR: 9-30）；66%是男性。生枣椰汁是主要的传播途径（92%）。niv - bd2的地理分布更广，南部地区也有分布。亚谱系在年龄、性别或传播方式上没有显著差异。两种亚系均表现为发热、精神状态改变和昏迷。niv - bd2患者呼吸窘迫更为频繁（23/29例），而niv - bd1患者住院时间更长(中位数：3天；差:1)。总死亡率为84%，亚系间无显著差异。系统发育分析表明，niv - bd1和niv - bd2的核苷酸同源性为98.72% ~ 99.25%，氨基酸同源性为99.98% ~ 99.99%。结构核蛋白(N)和基质(M)蛋白在亚谱系中保持保守。结论：本研究强调了亚谱系之间的遗传、时空和临床差异，强调了持续的基因组监测，为未来的疫苗和治疗策略提供信息。

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Epidemiology, clinical characteristics, and genetic diversity of Nipah virus strains from Bangladesh: 2016-2023

Objectives

Nipah virus (NiV) causes deadly outbreaks in Bangladesh, with a fatality rate of 71%. Two sublineages, NiV-BD 1 and NiV-BD 2, have been identified. This study aimed to characterize their epidemiologic and clinical diversity.

Methods

This study analyzed 21 new (2016-2023) and 17 previously (2012-2015) reported NiV genome sequences and compared sublineages using descriptive and bivariate analysis.

Results

The median age of sequenced cases was 17 years (Interquartile Range (IQR): 9-30), 66% were male. Raw date palm sap consumption was main transmission pathway (92%). NiV-BD 2 showed a broader geographic distribution, including the southern region. The sublineages did not differ significantly in age, sex, or transmission modes. Both sublineages presented with fever, altered mental status, and unconsciousness. Respiratory distress was more frequent in NiV-BD 2 (23 of 29 cases), whereas hospitalization was longer for NiV-BD 1 (median: 3 days; IQR: 1-23). The overall mortality was 84%, with no significant difference between sublineages. Phylogenetic analysis demonstrated that NiV-BD 1 and NiV-BD 2 formed distinct clusters with 98.72-99.25% nucleotide and 99.98-99.99% amino acid identity. The structural nucleoprotein and matrix proteins remained conserved across sublineages.

Conclusions

This study highlights genetic, spatio-temporal, and clinical variation between sublineages, emphasizing continuous genomic surveillance to inform future vaccine and therapeutic strategies.

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.