Jennie Hultgren, Matthias H Hafsteinsson, Joel Gruneau Brulin
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引用次数: 0
摘要
背景:裸盖菇素辅助疗法(PAT)在治疗抑郁症状方面显示出良好的效果,但其治疗成分的作用尚不清楚。虽然大多数研究都集中在裸盖菇素的药理作用上,但治疗的作用在很大程度上被忽视了。目的:本荟萃分析调查了提供的治疗时数是否与裸盖菇素辅助治疗抑郁症的治疗结果相关。方法:系统检索PubMed和PsycINFO,得到1095条记录。16项研究符合纳入标准,为分析提供了足够的数据。进行meta回归来评估治疗时间与治疗结果之间的关系。结果:无论短期(Cohen’s d = 1.69)还是长期随访(Cohen’s d = 2.10),总体治疗效果均较大。然而,无论在短期(b = -0.05, p = .327)还是长期(b = -0.07, p = .340)分析中,治疗时间与结果之间均未发现显著关联。所有纳入的研究都提供了一定程度的治疗(4.5-18小时)。结论:我们的研究结果不支持治疗时间长短影响PAT患者的抑郁结局。然而,由于样本量小、异质性和研究中治疗成分的报告不足,这种解释应该谨慎进行。未来的研究应采用更严格的方法和标准化的治疗报告,以阐明其在PAT中的作用。
A dose of therapy with psilocybin - A meta-analysis of the relationship between the amount of therapy hours and treatment outcomes in psychedelic-assisted therapy.
Background: Psilocybin-assisted therapy (PAT) has shown promising effects in treating depressive symptoms, but the role of the therapeutic component remains unclear. While most research has focused on the pharmacological effects of psilocybin, the contribution of therapy has been largely overlooked.
Objective: This meta-analysis investigated whether the amount of therapy hours provided is associated with treatment outcomes in psilocybin-assisted therapy for depression.
Methods: A systematic search of PubMed and PsycINFO yielded 1095 records. Sixteen studies met inclusion criteria, providing sufficient data for analysis. A meta-regression was conducted to assess the relationship between therapy hours and treatment outcomes.
Results: The overall treatment effect was large both in the short-term (Cohen's d = 1.69) and long-term follow-up (Cohen's d = 2.10). However, no significant association was found between the number of therapy hours and outcome in either the short-term (b = -0.05, p = .327) or long-term (b = -0.07, p = .340) analyses. All of the included studies provided some degree of therapy (4.5-18 h).
Conclusions: Our findings did not support that the amount of therapy hours influence depressive outcomes in PAT. However, this interpretation should be made with caution due to small sample sizes, heterogeneity, and poor reporting of the therapeutic component across studies. Future research should apply greater methodological rigor and standardized reporting of therapy to clarify its role in PAT.
期刊介绍:
General Hospital Psychiatry explores the many linkages among psychiatry, medicine, and primary care. In emphasizing a biopsychosocial approach to illness and health, the journal provides a forum for professionals with clinical, academic, and research interests in psychiatry''s role in the mainstream of medicine.