Meng-Nan Li, Bo Cao, Yan-Ling Wang, Hang Zhou, Hai-Xu Yao, Yuan Gao, Xi-Wei Zhuang, Jian-Lei Liu, Chi-Jia Zeng, Susan Zhou, Da-Ling Zhu, Jian Ma, Fei-Yun Cui
{"title":"V2CTx mxene驱动手持式SERS生物传感器，用于病毒抗原检测","authors":"Meng-Nan Li, Bo Cao, Yan-Ling Wang, Hang Zhou, Hai-Xu Yao, Yuan Gao, Xi-Wei Zhuang, Jian-Lei Liu, Chi-Jia Zeng, Susan Zhou, Da-Ling Zhu, Jian Ma, Fei-Yun Cui","doi":"10.1007/s12598-025-03408-6","DOIUrl":null,"url":null,"abstract":"<p>The intrinsic property of MXenes to adsorb dyes with high Raman scattering cross-sections makes them promising candidates for surface-enhanced Raman scattering (SERS) biosensors. In the study, we report a vanadium carbide MXene (V<sub>2</sub>CT<sub><i>x</i></sub>)-based SERS biosensor tag, V<sub>2</sub>CT<sub><i>x</i></sub>@Thi (thionine)@Au NPs (gold nanoparticles)-Ab (antibody), owing to its large interlayer spacing and superior dye adsorption capacity. The tag V<sub>2</sub>CT<sub><i>x</i></sub>@Thi@Au NPs-Ab was fully characterized and validated, demonstrating a significantly enhanced Raman signal through both electromagnetic and chemical enhancement mechanisms. Using a handheld Raman spectrometer as a readout tool, the developed handheld SERS biosensor was successfully applied for the detection of viral antigens. The biosensor exhibited excellent linearity (1.562–100 nM) and achieved a low limit of detection (LOD) 1.562 nM. Moreover, the biosensor demonstrated good selectivity and stability for detecting the target S protein in saliva samples. Our study highlights the potential of V<sub>2</sub>CT<sub><i>x</i></sub> MXene as a powerful material for handheld SERS biosensors, paving the way for portable and efficient viral diagnostics.</p>","PeriodicalId":749,"journal":{"name":"Rare Metals","volume":"44 9","pages":"6442 - 6455"},"PeriodicalIF":11.0000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"V2CTx MXene-powered handheld SERS biosensor for the viral antigen test\",\"authors\":\"Meng-Nan Li, Bo Cao, Yan-Ling Wang, Hang Zhou, Hai-Xu Yao, Yuan Gao, Xi-Wei Zhuang, Jian-Lei Liu, Chi-Jia Zeng, Susan Zhou, Da-Ling Zhu, Jian Ma, Fei-Yun Cui\",\"doi\":\"10.1007/s12598-025-03408-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The intrinsic property of MXenes to adsorb dyes with high Raman scattering cross-sections makes them promising candidates for surface-enhanced Raman scattering (SERS) biosensors. In the study, we report a vanadium carbide MXene (V<sub>2</sub>CT<sub><i>x</i></sub>)-based SERS biosensor tag, V<sub>2</sub>CT<sub><i>x</i></sub>@Thi (thionine)@Au NPs (gold nanoparticles)-Ab (antibody), owing to its large interlayer spacing and superior dye adsorption capacity. The tag V<sub>2</sub>CT<sub><i>x</i></sub>@Thi@Au NPs-Ab was fully characterized and validated, demonstrating a significantly enhanced Raman signal through both electromagnetic and chemical enhancement mechanisms. Using a handheld Raman spectrometer as a readout tool, the developed handheld SERS biosensor was successfully applied for the detection of viral antigens. The biosensor exhibited excellent linearity (1.562–100 nM) and achieved a low limit of detection (LOD) 1.562 nM. Moreover, the biosensor demonstrated good selectivity and stability for detecting the target S protein in saliva samples. Our study highlights the potential of V<sub>2</sub>CT<sub><i>x</i></sub> MXene as a powerful material for handheld SERS biosensors, paving the way for portable and efficient viral diagnostics.</p>\",\"PeriodicalId\":749,\"journal\":{\"name\":\"Rare Metals\",\"volume\":\"44 9\",\"pages\":\"6442 - 6455\"},\"PeriodicalIF\":11.0000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Rare Metals\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12598-025-03408-6\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rare Metals","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s12598-025-03408-6","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
V2CTx MXene-powered handheld SERS biosensor for the viral antigen test
The intrinsic property of MXenes to adsorb dyes with high Raman scattering cross-sections makes them promising candidates for surface-enhanced Raman scattering (SERS) biosensors. In the study, we report a vanadium carbide MXene (V2CTx)-based SERS biosensor tag, V2CTx@Thi (thionine)@Au NPs (gold nanoparticles)-Ab (antibody), owing to its large interlayer spacing and superior dye adsorption capacity. The tag V2CTx@Thi@Au NPs-Ab was fully characterized and validated, demonstrating a significantly enhanced Raman signal through both electromagnetic and chemical enhancement mechanisms. Using a handheld Raman spectrometer as a readout tool, the developed handheld SERS biosensor was successfully applied for the detection of viral antigens. The biosensor exhibited excellent linearity (1.562–100 nM) and achieved a low limit of detection (LOD) 1.562 nM. Moreover, the biosensor demonstrated good selectivity and stability for detecting the target S protein in saliva samples. Our study highlights the potential of V2CTx MXene as a powerful material for handheld SERS biosensors, paving the way for portable and efficient viral diagnostics.
期刊介绍：
Rare Metals is a monthly peer-reviewed journal published by the Nonferrous Metals Society of China. It serves as a platform for engineers and scientists to communicate and disseminate original research articles in the field of rare metals. The journal focuses on a wide range of topics including metallurgy, processing, and determination of rare metals. Additionally, it showcases the application of rare metals in advanced materials such as superconductors, semiconductors, composites, and ceramics.
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