从患有免疫检查点抑制剂相关重症肌无力、肌炎和心肌炎重叠综合征的恶性黑色素瘤患者中诱导多能干细胞系的产生

IF 0.7 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2025-08-06 DOI:10.1016/j.scr.2025.103797

Diem Thi Ngoc Huynh , Chikage Noishiki , Jacquelyn Lai , Pourya Yarahmadi , Thao Le , Dipti Tripathi , Ines Ross Tacco , Amit Manhas , Karim Sallam , Ian Y. Chen , Nazish Sayed , Patricia K. Nguyen

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引用次数: 0

摘要

免疫检查点抑制剂（ICI）是一类关键的免疫肿瘤治疗药物，提高了癌症患者的生存率。然而，它们的广泛使用受到限制，因为它们会产生严重和潜在致命的ici相关副作用。为了开发新的诊断和治疗策略来识别和治疗处于危险中的患者，我们需要更好地了解介导这些潜在致命副作用的潜在机制。为了达到这一目标，我们从患有ici相关性重症肌无力、肌炎和心肌炎重叠综合征的黑色素瘤患者的外周血单个核细胞中产生并验证了诱导多能干细胞。

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Generation of an induced pluripotent stem cell line from a malignant melanoma patient who developed the immune checkpoint inhibitor-related myasthenia gravis, myositis, and myocarditis overlap syndrome

Immune checkpoint inhibitors (ICI) are a pivotal class of immuno-oncology therapeutics that have improved survival rates for patients with cancer. Their widespread usage, however, is limited due to the development of serious and potentially deadly ICI-related side effects. To develop novel diagnostic and therapeutic strategies to identify and treat patients at risk, we need a better understanding of the underlying mechanisms mediating these potentially deadly side effects. To reach this goal, we have generated and validated induced pluripotent stem cells from the peripheral blood mononuclear cells of a melanoma patient who developed ICI-related myasthenia gravis, myositis, and myocarditis overlap syndrome.

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.