{"title":"内质网应激的病理生理和右美托咪定作为调节剂的潜在作用","authors":"Negin Karamali, Reihaneh Khaleghi Moghadam, Mohammad Borzabadi Farahani, Arman Rostamlou, Mirhamed Hoseini-Aghdam, Amirhossein Mardi, Behzad Baradaran, Leili Aghebati-Maleki","doi":"10.1002/biof.70022","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Endoplasmic reticulum (ER) stress is a fundamental process that profoundly influences immune cell function and plays a critical role in the development and progression of various physiological and pathological conditions. Understanding the underlying mechanisms of ER stress and its implications for cellular function and disease pathogenesis is of paramount importance in developing targeted therapeutic interventions. Dexmedetomidine, an alpha-2 adrenergic agonist primarily used as a sedative, has emerged as a potential modulator of ER stress. This review aims to explore the impact of Dexmedetomidine on ER stress within immune cells and its potential therapeutic implications. Dexmedetomidine exhibits the remarkable ability to inhibit the activation of ER stress pathways, preserve protein synthesis, and suppress apoptosis mediated by ER stress markers. Furthermore, Dexmedetomidine exerts regulatory effects on immune cells and inflammation by reducing the production of proinflammatory cytokines and modulating immune functions. These compelling findings suggest that Dexmedetomidine holds significant promise as a valuable therapeutic tool for conditions characterized by dysregulated ER stress and immune dysfunction.</p>\n </div>","PeriodicalId":8923,"journal":{"name":"BioFactors","volume":"51 4","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pathophysiology of Endoplasmic Reticulum Stress and the Potential Role of Dexmedetomidine as a Modulator\",\"authors\":\"Negin Karamali, Reihaneh Khaleghi Moghadam, Mohammad Borzabadi Farahani, Arman Rostamlou, Mirhamed Hoseini-Aghdam, Amirhossein Mardi, Behzad Baradaran, Leili Aghebati-Maleki\",\"doi\":\"10.1002/biof.70022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Endoplasmic reticulum (ER) stress is a fundamental process that profoundly influences immune cell function and plays a critical role in the development and progression of various physiological and pathological conditions. Understanding the underlying mechanisms of ER stress and its implications for cellular function and disease pathogenesis is of paramount importance in developing targeted therapeutic interventions. Dexmedetomidine, an alpha-2 adrenergic agonist primarily used as a sedative, has emerged as a potential modulator of ER stress. This review aims to explore the impact of Dexmedetomidine on ER stress within immune cells and its potential therapeutic implications. Dexmedetomidine exhibits the remarkable ability to inhibit the activation of ER stress pathways, preserve protein synthesis, and suppress apoptosis mediated by ER stress markers. Furthermore, Dexmedetomidine exerts regulatory effects on immune cells and inflammation by reducing the production of proinflammatory cytokines and modulating immune functions. These compelling findings suggest that Dexmedetomidine holds significant promise as a valuable therapeutic tool for conditions characterized by dysregulated ER stress and immune dysfunction.</p>\\n </div>\",\"PeriodicalId\":8923,\"journal\":{\"name\":\"BioFactors\",\"volume\":\"51 4\",\"pages\":\"\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-08-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BioFactors\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.70022\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioFactors","FirstCategoryId":"99","ListUrlMain":"https://iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.70022","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Pathophysiology of Endoplasmic Reticulum Stress and the Potential Role of Dexmedetomidine as a Modulator
Endoplasmic reticulum (ER) stress is a fundamental process that profoundly influences immune cell function and plays a critical role in the development and progression of various physiological and pathological conditions. Understanding the underlying mechanisms of ER stress and its implications for cellular function and disease pathogenesis is of paramount importance in developing targeted therapeutic interventions. Dexmedetomidine, an alpha-2 adrenergic agonist primarily used as a sedative, has emerged as a potential modulator of ER stress. This review aims to explore the impact of Dexmedetomidine on ER stress within immune cells and its potential therapeutic implications. Dexmedetomidine exhibits the remarkable ability to inhibit the activation of ER stress pathways, preserve protein synthesis, and suppress apoptosis mediated by ER stress markers. Furthermore, Dexmedetomidine exerts regulatory effects on immune cells and inflammation by reducing the production of proinflammatory cytokines and modulating immune functions. These compelling findings suggest that Dexmedetomidine holds significant promise as a valuable therapeutic tool for conditions characterized by dysregulated ER stress and immune dysfunction.
期刊介绍:
BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease.
The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements.
In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.