奈比洛尔和他达拉非协同改善大鼠胰岛素抵抗性视网膜病变

IF 3.6 3区 医学 Q2 CHEMISTRY, MEDICINAL
Hussein K. Seif, Dalia Mandour, Islam A. A. E.-H. Ibrahim, Mona F. Mahmoud, Mahmoud H. Elbatreek
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引用次数: 0

摘要

视网膜病变是胰岛素抵抗的严重并发症。我们的目的是研究奈比洛尔和/或他达拉非对胰岛素抵抗性视网膜病变的治疗效果。采用高果糖、高脂肪、高盐饮食模型诱导大鼠胰岛素抵抗。在目前的研究中使用了五组:标准饲料(SCD), HFrFSD,奈比洛尔,他达拉非及其半剂量组合。在实验结束时,测量肥胖和代谢变化的标志物;此外,视网膜氧化应激、血管反应性、细胞凋亡、纤维化和血管生成标志物的变化。同时记录组织病理变化。用HFrFSD喂养大鼠会导致肥胖、胰岛素抵抗和视网膜组织变形,这些与视网膜氧化应激、血管病变、细胞凋亡和血管生成增加有关。奈比洛尔和他达拉非均未引起肥胖、碳水化合物和脂质代谢标志物的显著改变,但显著降低了视网膜组织的组织病理学和分子变化。有趣的是,与HFrFSD组相比,半剂量奈比洛尔和他达拉非联合治疗显著降低了空腹血糖水平和胰岛素抵抗,而不影响肥胖标志物和脂质代谢,与全剂量单独治疗相比,对视网膜病变有更高的保护作用。综上所述,奈比洛尔和他达拉非可协同改善大鼠胰岛素抵抗性视网膜病变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nebivolol and Tadalafil Synergistically Ameliorate Insulin Resistance-Induced Retinopathy in Rats

Retinopathy is a serious complication of insulin resistance. We aimed to investigate the therapeutic effect of nebivolol and/or tadalafil on insulin resistance-induced retinopathy. Insulin resistance was induced in rats using a dietary model of a high-fructose, high-fat, high-salt diet (HFrFSD). Five groups were used in the current study: standard chow diet (SCD), HFrFSD, nebivolol, tadalafil, and their half doses combination. At the end of the experiment, markers of obesity and metabolic changes were measured; moreover, changes in retinal oxidative stress, vascular reactivity, apoptosis, fibrosis, and angiogenesis markers. Histopathological changes were also recorded. Feeding rats with HFrFSD induced obesity, insulin resistance, and retinal tissue distortions, which were associated with increased retinal oxidative stress, vasculopathy, apoptosis, and angiogenesis. Both nebivolol and tadalafil did not cause significant changes in the markers of obesity, carbohydrate, and lipid metabolism, while they significantly reduced retinal tissue histopathological and molecular changes. Interestingly, the half-dose combination of nebivolol and tadalafil significantly reduced fasting blood glucose levels and insulin resistance compared with the HFrFSD group without affecting obesity markers and lipid metabolism and showed higher protective effects against retinopathy compared with the full dose individual treatments. In conclusion, nebivolol and tadalafil synergistically ameliorate insulin resistance-induced retinopathy in rats.

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来源期刊
Archiv der Pharmazie
Archiv der Pharmazie 医学-化学综合
CiteScore
7.90
自引率
5.90%
发文量
176
审稿时长
3.0 months
期刊介绍: Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.
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