L. Morales-Fernandez, C. Heredia-Pastor, P. Talavero, I. Collado, J. Garcia-Feijoo, R. Gomez-de-Liaño
{"title":"使用DIVE设备自动测量原发性先天性青光眼的眼球运动异常：固定、平滑追踪和跳眼运动的初步研究。","authors":"L. Morales-Fernandez, C. Heredia-Pastor, P. Talavero, I. Collado, J. Garcia-Feijoo, R. Gomez-de-Liaño","doi":"10.1016/j.oftale.2025.06.009","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>Primary congenital glaucoma (PCG) is a significant cause of childhood vision loss. While visual acuity can be measured, it does not always reflect visual functioning in daily life, particularly as oculomotor skills are often compromised in ocular disorders. This pilot study assesses oculomotor behavior in children with PCG compared to healthy peers using the Device for an Integral Visual Examination (DIVE).</div></div><div><h3>Methods</h3><div>Twelve children with PCG (n = 24 eyes) and 24 healthy children (n = 48 eyes), aged 6 months to 4 years, were recruited. DIVE was used for automated oculomotor assessments, measuring fixation (gaze stability, fixation stability, and duration of fixation), saccadic movements (reaction time, peak velocity), and smooth pursuit (latency, gain).</div></div><div><h3>Results</h3><div>PCG children showed significantly poorer gaze stability in both short (0.68 log degree<sup>2</sup>, 0.29–0.94 frente a 0.15 log degree<sup>2</sup>, −0.17–0.59; p < 0.05) and long tasks (1.08 log degree<sup>2</sup>, 0.79–1.84 frente a 0.57 log degree<sup>2</sup>, 0.30–0.85; p < 0.05), and poorer fixation stability in short (−0.20 log degree<sup>2</sup>, −0.27 to −0.17 frente a −0.48 log degree<sup>2</sup>, −0.55 to −0.30; p < 0.05) and long tasks (−0.11 log degree<sup>2</sup>, −0.20 to −0.04 frente a −0.41 log degree<sup>2</sup>, −0.57 to −0.26; p < 0.05). Fixation durations were shorter, and saccadic reaction times were longer in the PCG group, while pursuit latency showed no significant difference (<em>p = 0.8118</em>).</div></div><div><h3>Conclusions</h3><div>Children with PCG have significantly impaired oculomotor behavior, including greater instability in gaze and fixation, shorter fixation durations, and longer saccadic reaction times compared to healthy peers.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 610-617"},"PeriodicalIF":0.0000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Automated measurement of ocular movements abnormalities in primary congenital glaucoma using DIVE device: A pilot study of fixation, smooth pursuit and saccadic movements\",\"authors\":\"L. Morales-Fernandez, C. Heredia-Pastor, P. Talavero, I. Collado, J. Garcia-Feijoo, R. Gomez-de-Liaño\",\"doi\":\"10.1016/j.oftale.2025.06.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>Primary congenital glaucoma (PCG) is a significant cause of childhood vision loss. While visual acuity can be measured, it does not always reflect visual functioning in daily life, particularly as oculomotor skills are often compromised in ocular disorders. This pilot study assesses oculomotor behavior in children with PCG compared to healthy peers using the Device for an Integral Visual Examination (DIVE).</div></div><div><h3>Methods</h3><div>Twelve children with PCG (n = 24 eyes) and 24 healthy children (n = 48 eyes), aged 6 months to 4 years, were recruited. DIVE was used for automated oculomotor assessments, measuring fixation (gaze stability, fixation stability, and duration of fixation), saccadic movements (reaction time, peak velocity), and smooth pursuit (latency, gain).</div></div><div><h3>Results</h3><div>PCG children showed significantly poorer gaze stability in both short (0.68 log degree<sup>2</sup>, 0.29–0.94 frente a 0.15 log degree<sup>2</sup>, −0.17–0.59; p < 0.05) and long tasks (1.08 log degree<sup>2</sup>, 0.79–1.84 frente a 0.57 log degree<sup>2</sup>, 0.30–0.85; p < 0.05), and poorer fixation stability in short (−0.20 log degree<sup>2</sup>, −0.27 to −0.17 frente a −0.48 log degree<sup>2</sup>, −0.55 to −0.30; p < 0.05) and long tasks (−0.11 log degree<sup>2</sup>, −0.20 to −0.04 frente a −0.41 log degree<sup>2</sup>, −0.57 to −0.26; p < 0.05). Fixation durations were shorter, and saccadic reaction times were longer in the PCG group, while pursuit latency showed no significant difference (<em>p = 0.8118</em>).</div></div><div><h3>Conclusions</h3><div>Children with PCG have significantly impaired oculomotor behavior, including greater instability in gaze and fixation, shorter fixation durations, and longer saccadic reaction times compared to healthy peers.</div></div>\",\"PeriodicalId\":93886,\"journal\":{\"name\":\"Archivos de la Sociedad Espanola de Oftalmologia\",\"volume\":\"100 10\",\"pages\":\"Pages 610-617\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archivos de la Sociedad Espanola de Oftalmologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2173579425001446\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos de la Sociedad Espanola de Oftalmologia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2173579425001446","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Automated measurement of ocular movements abnormalities in primary congenital glaucoma using DIVE device: A pilot study of fixation, smooth pursuit and saccadic movements
Purpose
Primary congenital glaucoma (PCG) is a significant cause of childhood vision loss. While visual acuity can be measured, it does not always reflect visual functioning in daily life, particularly as oculomotor skills are often compromised in ocular disorders. This pilot study assesses oculomotor behavior in children with PCG compared to healthy peers using the Device for an Integral Visual Examination (DIVE).
Methods
Twelve children with PCG (n = 24 eyes) and 24 healthy children (n = 48 eyes), aged 6 months to 4 years, were recruited. DIVE was used for automated oculomotor assessments, measuring fixation (gaze stability, fixation stability, and duration of fixation), saccadic movements (reaction time, peak velocity), and smooth pursuit (latency, gain).
Results
PCG children showed significantly poorer gaze stability in both short (0.68 log degree2, 0.29–0.94 frente a 0.15 log degree2, −0.17–0.59; p < 0.05) and long tasks (1.08 log degree2, 0.79–1.84 frente a 0.57 log degree2, 0.30–0.85; p < 0.05), and poorer fixation stability in short (−0.20 log degree2, −0.27 to −0.17 frente a −0.48 log degree2, −0.55 to −0.30; p < 0.05) and long tasks (−0.11 log degree2, −0.20 to −0.04 frente a −0.41 log degree2, −0.57 to −0.26; p < 0.05). Fixation durations were shorter, and saccadic reaction times were longer in the PCG group, while pursuit latency showed no significant difference (p = 0.8118).
Conclusions
Children with PCG have significantly impaired oculomotor behavior, including greater instability in gaze and fixation, shorter fixation durations, and longer saccadic reaction times compared to healthy peers.
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