Carolin Steinert, Margarita Pashuk, Pavel Kolkhir, Emek Kocatürk, Yi-Kui Xiang
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Purpose of the review: This review aims to educate allergists about the concept of autoallergy by addressing five questions: 1) What is autoallergy and how does it differ from classical allergy? 2) How common is autoallergy? 3) Is autoallergy clinically relevant? 4) How can autoallergy be diagnosed? and 5) How is autoallergy treated?
Recent findings: In contrast to type I hypersensitivity against external allergens (allergy), autoallergy involves IgE autoantibodies targeting self-antigens. These are found in conditions like chronic spontaneous urticaria, atopic dermatitis, and asthma, with varying prevalence. While no standardized diagnostic tools exist, ELISA and basophil activation tests help identify the presence and function of IgE autoantibodies. Anti-IgE therapies have shown benefit, supporting their clinical relevance. Autoallergy is emerging as a distinct IgE-mediated mechanism that may contribute to chronic inflammation in immune-mediated diseases. Further investigation of this mechanism can improve disease stratification and enable more effective, targeted treatment strategies.
期刊介绍：
The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma.
We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.
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