{"title":"一例青春期女孩肾鞘瘤：组织病理学观察与文献复习。","authors":"Keya Basu, Shristi Butta, Ayush Agarwal, Arijit Singha, Shyamalendu Medda, Debansu Sarkar, Uttara Chatterjee","doi":"10.1080/15513815.2025.2543743","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Reninoma is an uncommon mesenchymal tumor of the kidney. It is characterized by renin secretion and uncontrollable hypertension with associated hypokalemia. <b>Case report:</b> Here we report a case in a 15-year-old girl who presented with refractory hypertension, muscle weakness, and fatigue. Diagnostic workup revealed severe hypokalemia, metabolic alkalosis and elevated plasma renin activity with raised aldosterone levels. Renal artery doppler done to exclude renal artery stenosis, revealed a left sided renal mass. Simple nephrectomy was done and histopathological and immunohistochemical examination were consistent with a diagnosis of reninoma. Electron microscopy revealed renin crystals in the cytoplasm, thus confirming the diagnosis. <b>Conclusion:</b> This report underscores the importance of including reninoma in the differential diagnosis of secondary hypertension in an adolescent. Additionally, insights into histopathology and electron microscopy are important for the diagnosis of reninoma as there are several renal tumors that have renin-secreting activity.</p>","PeriodicalId":50452,"journal":{"name":"Fetal and Pediatric Pathology","volume":" ","pages":"495-502"},"PeriodicalIF":0.6000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reninoma in an Adolescent Girl: Histopathological Insights with Review of Literature.\",\"authors\":\"Keya Basu, Shristi Butta, Ayush Agarwal, Arijit Singha, Shyamalendu Medda, Debansu Sarkar, Uttara Chatterjee\",\"doi\":\"10.1080/15513815.2025.2543743\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> Reninoma is an uncommon mesenchymal tumor of the kidney. It is characterized by renin secretion and uncontrollable hypertension with associated hypokalemia. <b>Case report:</b> Here we report a case in a 15-year-old girl who presented with refractory hypertension, muscle weakness, and fatigue. Diagnostic workup revealed severe hypokalemia, metabolic alkalosis and elevated plasma renin activity with raised aldosterone levels. Renal artery doppler done to exclude renal artery stenosis, revealed a left sided renal mass. Simple nephrectomy was done and histopathological and immunohistochemical examination were consistent with a diagnosis of reninoma. Electron microscopy revealed renin crystals in the cytoplasm, thus confirming the diagnosis. <b>Conclusion:</b> This report underscores the importance of including reninoma in the differential diagnosis of secondary hypertension in an adolescent. Additionally, insights into histopathology and electron microscopy are important for the diagnosis of reninoma as there are several renal tumors that have renin-secreting activity.</p>\",\"PeriodicalId\":50452,\"journal\":{\"name\":\"Fetal and Pediatric Pathology\",\"volume\":\" \",\"pages\":\"495-502\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fetal and Pediatric Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/15513815.2025.2543743\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fetal and Pediatric Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15513815.2025.2543743","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/9 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}
Reninoma in an Adolescent Girl: Histopathological Insights with Review of Literature.
Background: Reninoma is an uncommon mesenchymal tumor of the kidney. It is characterized by renin secretion and uncontrollable hypertension with associated hypokalemia. Case report: Here we report a case in a 15-year-old girl who presented with refractory hypertension, muscle weakness, and fatigue. Diagnostic workup revealed severe hypokalemia, metabolic alkalosis and elevated plasma renin activity with raised aldosterone levels. Renal artery doppler done to exclude renal artery stenosis, revealed a left sided renal mass. Simple nephrectomy was done and histopathological and immunohistochemical examination were consistent with a diagnosis of reninoma. Electron microscopy revealed renin crystals in the cytoplasm, thus confirming the diagnosis. Conclusion: This report underscores the importance of including reninoma in the differential diagnosis of secondary hypertension in an adolescent. Additionally, insights into histopathology and electron microscopy are important for the diagnosis of reninoma as there are several renal tumors that have renin-secreting activity.
期刊介绍：
Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports.
The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.
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