2023/24年英格兰住院老年人呼吸道合胞病毒感染负担

IF 11.9 1区医学 Q1 INFECTIOUS DISEASES

Journal of Infection Pub Date : 2025-08-06 DOI:10.1016/j.jinf.2025.106570

Rebecca Symes , Suzanne H Keddie , Jemma Walker , Tricia McKeever , Shazaad Ahmad , David Arnold , Cariad M Evans , Emanuela Pelosi , Najib M Rahman , Elizabeth Sapey , Maria Zambon , Conall Watson , Jamie Lopez Bernal , Wei Shen Lim

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引用次数: 0

摘要

目的：我们旨在描述RSV相关急性呼吸道感染（ARI）的发病率、表现和临床结果，在RSV疫苗引入之前，使用英国新的国家医院ARI哨点监测（HARISS）系统。方法：纳入来自7家医院的年龄≥65岁的有症状性ARI住院≥24小时的成年人。与流感相关的ARI相比，我们估计了rsv相关ARI的住院率，并使用泊松回归评估临床结果，使用Cox回归评估死亡率。结果：本研究纳入2743名成年人。在2023/4年冬季，与rsv相关的ARI住院率为58.3 / 10万，而与流感相关的ARI住院率为114.6 / 10万。住院人数随年龄增长而增加。慢性疾病加重（肺病、心脏病、虚弱）是rsv相关ARI的常见入院原因，总发病率为33.1 / 10万。大多数与rsv相关的ARI成人至少有一种合并症（81%）；免疫抑制的比例很高（26%）。RSV和流感相关急性呼吸道感染的症状和临床结果（包括死亡率）相似；30天死亡率10.6% vs 8.7%（校正风险比0.85,95%可信区间0.6-1.2）。结论：在英格兰，呼吸道合胞病毒感染是老年人住院的常见原因。症状和临床结果，包括死亡率，与流感相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Burden of respiratory syncytial virus infection in older adults hospitalised in England during 2023/24

Objectives

We aimed to describe the incidence, presentation and clinical outcomes of RSV-associated acute respiratory infection (ARI) in older adults using a new national Hospital-based ARI Sentinel Surveillance (HARISS) system in England, prior to RSV vaccine introduction.

Methods

Adults aged ≥65 years from seven hospitals admitted for ≥24 hours with symptomatic ARI were included. We estimated the hospitalisation rate of RSV-associated ARI compared to influenza-associated ARI and assessed clinical outcomes using Poisson regression and mortality using Cox regression.

Results

This study included 2743 adults. During winter 2023/4 the hospitalisation rate for RSV-associated ARI was 58.3 per 100,000, compared to 114.6 per 100,000 for influenza-associated ARI. Hospitalisations increased with age. Exacerbation of chronic illness (lung disease, heart disease, frailty) was a common admission reason in RSV-associated ARI, with a combined incidence of 33.1 per 100,000. Most adults with RSV-associated ARI had at least one comorbidity (81%); a high proportion with immunosuppression (26%). Symptoms and clinical outcomes including mortality were similar between RSV- and influenza-associated ARI; 30-day mortality 10.6% vs 8.7% (adjusted hazard ratio 0.85, 95% confidence interval 0.6–1.2).

Conclusions

In England, RSV infection is a common cause of hospitalisation in older adults. Symptoms and clinical outcomes, including mortality, are comparable to influenza.

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来源期刊

Journal of Infection 医学-传染病学

CiteScore

45.90

自引率

3.20%

发文量

475

审稿时长

16 days

期刊介绍： The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.