听觉稳态反应在鉴别儿童听神经病变谱障碍中的应用:听神经直径正常与听神经发育不全。

IF 1.3 4区 医学 Q3 OTORHINOLARYNGOLOGY
Josilene Luciene Duarte, Eliene Silva Araújo, Amanda Gonçalves Silveira, Elisabete Honda Yamaguti, Eduardo Boaventura Oliveira, Bárbara Cristiane Sordi Silva, Lilian Cássia Bórnia Jacob, Kátia de Freitas Alvarenga
{"title":"听觉稳态反应在鉴别儿童听神经病变谱障碍中的应用:听神经直径正常与听神经发育不全。","authors":"Josilene Luciene Duarte, Eliene Silva Araújo, Amanda Gonçalves Silveira, Elisabete Honda Yamaguti, Eduardo Boaventura Oliveira, Bárbara Cristiane Sordi Silva, Lilian Cássia Bórnia Jacob, Kátia de Freitas Alvarenga","doi":"10.1016/j.ijporl.2025.112509","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Evaluations of Auditory Evoked Potentials, more specifically Auditory Steady-State Responses (ASSR) in children having Auditory Neuropathy Spectrum Disorder (ANSD) with normal auditory nerve diameter and ANSD with auditory nerve hypoplasia were performed, to analyze the feasibility of using ASSR as a predictor of behavioral thresholds in this population.</p><p><strong>Methods: </strong>In total, 27 children were evaluated; 17 diagnosed as ANSD with normal auditory nerve diameter (group 1) and 10 diagnosed as ANSD with auditory nerve hypoplasia (group 2). The participants' ages ranged from six months to 10 years and 9 months, and all had bilateral alterations; therefore, 54 ears were analyzed. The evaluation included (i) ASSR thresholds, in carrier frequencies of 0.5, 1, 2 and 4 kHz, 100 % modulated for amplitude and 20 % for frequency and (ii) behavioral auditory thresholds.</p><p><strong>Results: </strong>Among children having ANSD with normal auditory nerve diameter, a high number of absent responses was identified in ASSR, even at frequencies with behavioral threshold records. Conversely, among children having ANSD with auditory nerve hypoplasia, consistent ASSR were recorded, making it possible to determine the electrophysiological threshold for most frequencies evaluated in this study.</p><p><strong>Conclusion: </strong>In ANSD with normal auditory nerve diameter, ASSR do not provide additional information for predicting behavioral thresholds, requiring follow-up until the obtainment behavioral thresholds. Conversely, ASSR were consistently recorded in cases of ANSD with auditory nerve hypoplasia. Therefore, ASSR is a promising complementary tool for differential diagnosis between hypoplasia and auditory nerve aplasia and even between ANSD with normal auditory nerve diameter and ANSD with auditory nerve hypoplasia.</p>","PeriodicalId":14388,"journal":{"name":"International journal of pediatric otorhinolaryngology","volume":"196 ","pages":"112509"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Utility of auditory steady-state response in differentiating pediatric auditory neuropathy spectrum disorders: with normal auditory nerve diameter versus with auditory nerve hypoplasia.\",\"authors\":\"Josilene Luciene Duarte, Eliene Silva Araújo, Amanda Gonçalves Silveira, Elisabete Honda Yamaguti, Eduardo Boaventura Oliveira, Bárbara Cristiane Sordi Silva, Lilian Cássia Bórnia Jacob, Kátia de Freitas Alvarenga\",\"doi\":\"10.1016/j.ijporl.2025.112509\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Evaluations of Auditory Evoked Potentials, more specifically Auditory Steady-State Responses (ASSR) in children having Auditory Neuropathy Spectrum Disorder (ANSD) with normal auditory nerve diameter and ANSD with auditory nerve hypoplasia were performed, to analyze the feasibility of using ASSR as a predictor of behavioral thresholds in this population.</p><p><strong>Methods: </strong>In total, 27 children were evaluated; 17 diagnosed as ANSD with normal auditory nerve diameter (group 1) and 10 diagnosed as ANSD with auditory nerve hypoplasia (group 2). The participants' ages ranged from six months to 10 years and 9 months, and all had bilateral alterations; therefore, 54 ears were analyzed. The evaluation included (i) ASSR thresholds, in carrier frequencies of 0.5, 1, 2 and 4 kHz, 100 % modulated for amplitude and 20 % for frequency and (ii) behavioral auditory thresholds.</p><p><strong>Results: </strong>Among children having ANSD with normal auditory nerve diameter, a high number of absent responses was identified in ASSR, even at frequencies with behavioral threshold records. Conversely, among children having ANSD with auditory nerve hypoplasia, consistent ASSR were recorded, making it possible to determine the electrophysiological threshold for most frequencies evaluated in this study.</p><p><strong>Conclusion: </strong>In ANSD with normal auditory nerve diameter, ASSR do not provide additional information for predicting behavioral thresholds, requiring follow-up until the obtainment behavioral thresholds. Conversely, ASSR were consistently recorded in cases of ANSD with auditory nerve hypoplasia. Therefore, ASSR is a promising complementary tool for differential diagnosis between hypoplasia and auditory nerve aplasia and even between ANSD with normal auditory nerve diameter and ANSD with auditory nerve hypoplasia.</p>\",\"PeriodicalId\":14388,\"journal\":{\"name\":\"International journal of pediatric otorhinolaryngology\",\"volume\":\"196 \",\"pages\":\"112509\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of pediatric otorhinolaryngology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ijporl.2025.112509\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of pediatric otorhinolaryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ijporl.2025.112509","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:评估听神经病变谱系障碍(ANSD)伴听神经直径正常和ANSD伴听神经发育不全儿童的听觉诱发电位,特别是听觉稳态反应(ASSR),以分析使用ASSR作为该人群行为阈值预测指标的可行性。方法:对27例患儿进行评估;听神经直径正常的ANSD 17例(1组),听神经发育不全的ANSD 10例(2组)。参与者的年龄从6个月到10岁9个月不等,并且都有双侧改变;因此,对54只耳朵进行了分析。评估包括(i) ASSR阈值,在0.5、1、2和4 kHz的载波频率中,100%调制幅度和20%调制频率,以及(ii)行为听觉阈值。结果:在听神经直径正常的ANSD儿童中,在ASSR中发现了大量的缺失反应,即使在有行为阈值记录的频率上也是如此。相反,在伴有听神经发育不全的ANSD儿童中,记录到一致的ASSR,从而可以确定本研究中评估的大多数频率的电生理阈值。结论:在听神经直径正常的ANSD中,ASSR不能提供预测行为阈值的额外信息,需要随访,直到获得行为阈值。相反,在伴有听神经发育不全的ANSD病例中,ASSR的记录一致。因此,ASSR是鉴别听神经发育不全与听神经发育不全,甚至听神经直径正常的ANSD与听神经发育不全的ANSD的一种很有前景的辅助诊断工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Utility of auditory steady-state response in differentiating pediatric auditory neuropathy spectrum disorders: with normal auditory nerve diameter versus with auditory nerve hypoplasia.

Purpose: Evaluations of Auditory Evoked Potentials, more specifically Auditory Steady-State Responses (ASSR) in children having Auditory Neuropathy Spectrum Disorder (ANSD) with normal auditory nerve diameter and ANSD with auditory nerve hypoplasia were performed, to analyze the feasibility of using ASSR as a predictor of behavioral thresholds in this population.

Methods: In total, 27 children were evaluated; 17 diagnosed as ANSD with normal auditory nerve diameter (group 1) and 10 diagnosed as ANSD with auditory nerve hypoplasia (group 2). The participants' ages ranged from six months to 10 years and 9 months, and all had bilateral alterations; therefore, 54 ears were analyzed. The evaluation included (i) ASSR thresholds, in carrier frequencies of 0.5, 1, 2 and 4 kHz, 100 % modulated for amplitude and 20 % for frequency and (ii) behavioral auditory thresholds.

Results: Among children having ANSD with normal auditory nerve diameter, a high number of absent responses was identified in ASSR, even at frequencies with behavioral threshold records. Conversely, among children having ANSD with auditory nerve hypoplasia, consistent ASSR were recorded, making it possible to determine the electrophysiological threshold for most frequencies evaluated in this study.

Conclusion: In ANSD with normal auditory nerve diameter, ASSR do not provide additional information for predicting behavioral thresholds, requiring follow-up until the obtainment behavioral thresholds. Conversely, ASSR were consistently recorded in cases of ANSD with auditory nerve hypoplasia. Therefore, ASSR is a promising complementary tool for differential diagnosis between hypoplasia and auditory nerve aplasia and even between ANSD with normal auditory nerve diameter and ANSD with auditory nerve hypoplasia.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.20
自引率
6.70%
发文量
276
审稿时长
62 days
期刊介绍: The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信