解决辅助内分泌治疗依从性的健康素养差距：来自随机远程监测试验的事后见解

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI:10.1016/j.breast.2025.104552

Ilana Graetz, Samuel Hernandez, Xin Hu, Rebecca A Krukowski, Janeane N Anderson, Teresa M Waters, Edward Stepanski, Gregory A Vidal, Lee S Schwartzberg

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引用次数: 0

摘要

辅助内分泌治疗（AET）可提高激素受体阳性乳腺癌患者的生存率，但在健康素养有限的个体中，依从性往往较低。这项对THRIVE试验的事后分析检验了健康素养是否改变了两种远程监测干预（仅应用程序和应用程序+反馈）与增强常规护理（EUC）对12个月AET依从性（通过连接的药盒提供处方剂量的≥80%）的有效性。在健康素养较低的参与者中，App + Feedback的依从性高于EUC(80.0%对42.1%,p = 0.03)，而在健康素养较高的参与者中没有显著差异。量身定制的数字干预措施可支持健康素养有限的患者的依从性。临床试验：ClinicalTrial.gov识别码NCT03592771。

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Addressing health literacy gaps in adjuvant endocrine therapy adherence: Post hoc insights from a randomized remote monitoring trial.

Adjuvant endocrine therapy (AET) improves survival in hormone receptor-positive breast cancer, yet adherence is often lower among individuals with limited health literacy. This post hoc analysis of the THRIVE trial examined whether health literacy modified the effectiveness of two remote monitoring interventions (App-only and App + Feedback) versus enhanced usual care (EUC) on 12-month AET adherence (≥80 % of prescribed doses via connected pillbox). Among participants with lower health literacy, adherence was higher with App + Feedback than EUC (80.0 % vs. 42.1 %, p = 0.03), with no significant differences among those with higher health literacy. Tailored digital interventions may support adherence among patients with limited health literacy. TRIAL: ClinicalTrial.gov identifier NCT03592771.

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来源期刊

Breast 医学-妇产科学

CiteScore

8.70

自引率

2.60%

发文量

165

审稿时长

59 days

期刊介绍： The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.