用机器学习估计血浆容量以提高运动员生物护照的解释。

IF 2.7 3区 医学 Q2 BIOCHEMICAL RESEARCH METHODS
Bastien Krumm, Laura Lewis, Jakob Mørkeberg, Yorck Olaf Schumacher, Giuseppe d'Onofrio, Basile Moreillon, Raphael Faiss
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引用次数: 0

摘要

识别与血浆体积(PV)波动相关的混杂因素对于运动员生物护照(ABP)资料的适当定性解释至关重要。作为从血红蛋白浓度([Hb])等基于浓度的生物标志物中去除PV方差的持续努力的一部分,在ABP框架内应用了一种新的机器学习模型,该模型使用单个全血细胞计数分析来估计血容量(BV)。使用了40个来自优秀运动员和健康对照者的现有ABP谱。PV是使用在以前的数据集上训练的机器学习模型来估计的。首先,在单个剖面的叠加中添加了估计PV位移的可视化显示。另外,在新的图形配置文件中调整个体[Hb]阈值以解释PV变化。最后,将一组带有PV估计的ABP剖面提交给ABP专家,以评估该模型在解释血液学数据中的相关性。两名男性的PV测量值和估计值之间存在中度相关性(r = 0.40, p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimation of Plasma Volume by Machine Learning to Improve the Interpretation of the Athlete Biological Passport.

The identification of confounding factors related to plasma volume (PV) fluctuations is crucial for appropriate qualitative interpretations of Athlete Biological Passport (ABP) profiles. As part of ongoing efforts to remove PV variance from the concentration-based biomarkers such as hemoglobin concentration ([Hb]), a new machine learning model for blood volume (BV) estimation using a single complete blood count analysis was applied within the ABP framework. Forty existing ABP profiles from elite athletes and healthy control subjects were used. PV was estimated using a machine learning model trained on a previous dataset. First, a visual display of the estimated PV shift was added in overlay of individual profiles. Alternatively, individual [Hb] thresholds were adjusted in a new graphical profile to account for PV variations. Finally, a set of ABP profiles with PV estimations was presented to ABP experts to assess the model's relevance in interpreting hematological data. A moderate correlation was found between measured and estimated PV in both men (r = 0.40, p < 0.0001) and women (r = 0.39, p < 0.0001), supporting the validity of the estimation model. In addition, ABP experts favorably assessed the available PV information, particularly the visual representation of PV. This novel estimation model offers distinct advantages (e.g., same biomarkers currently analyzed from routine ABP analyses) and could therefore be of particular interest. Further application of this model in the presence of specific and transient confounding factors may allow to confirm these results.

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来源期刊
Drug Testing and Analysis
Drug Testing and Analysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL
CiteScore
5.90
自引率
24.10%
发文量
191
审稿时长
2.3 months
期刊介绍: As the incidence of drugs escalates in 21st century living, their detection and analysis have become increasingly important. Sport, the workplace, crime investigation, homeland security, the pharmaceutical industry and the environment are just some of the high profile arenas in which analytical testing has provided an important investigative tool for uncovering the presence of extraneous substances. In addition to the usual publishing fare of primary research articles, case reports and letters, Drug Testing and Analysis offers a unique combination of; ‘How to’ material such as ‘Tutorials’ and ‘Reviews’, Speculative pieces (‘Commentaries’ and ‘Perspectives'', providing a broader scientific and social context to the aspects of analytical testing), ‘Annual banned substance reviews’ (delivering a critical evaluation of the methods used in the characterization of established and newly outlawed compounds). Rather than focus on the application of a single technique, Drug Testing and Analysis employs a unique multidisciplinary approach to the field of controversial compound determination. Papers discussing chromatography, mass spectrometry, immunological approaches, 1D/2D gel electrophoresis, to name just a few select methods, are welcomed where their application is related to any of the six key topics listed below.
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