父母接触邻苯二甲酸盐与胎儿生长和胎盘发育的关系。

IF 2.8 4区 医学 Q2 REPRODUCTIVE BIOLOGY
Reproductive toxicology Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI:10.1016/j.reprotox.2025.109025
Hye Jin Chang, Yoon Hee Cho, Yeong Sook Yoon, Younglim Kho, Je Yeon Lee, Dong Won Hwang, Jung Yeol Han, Jisun Lee, Young Ah Kim
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引用次数: 0

摘要

背景:据报道,产前接触邻苯二甲酸盐会影响胎儿生长,并可能对婴儿及其未来发育产生持久的不良影响;然而,结果仍然没有定论。目的:本研究利用73对孕妇-新生儿(包括生父(73三合组))的出生队列研究怀孕期间父母邻苯二甲酸盐暴露与新生儿出生结局的关系。方法:在分娩前收集父母双方的人口学、行为和临床信息以及尿液样本。在尿样中定量测定16种邻苯二甲酸酯代谢物。结果:6种邻苯二甲酸酯代谢物(MEP、MiBP、MnBP、MBzP、MEHP和5cx-MEPP)在母体尿液和父系尿液中存在显著相关性。母亲MBzP与男孩出生体重呈正相关,而母亲2cx-MMHP与女孩出生体重呈负相关。校正混杂变量后,男孩的体重指数与母亲的MBzP和MMP呈负相关,与母亲的∑MEHP-3和∑MEHP-5呈正相关。在父亲邻苯二甲酸酯中,MBzP与男孩的体重指数呈负相关,而MEP与男孩的体重指数呈正相关。母亲MEOHP、∑MEHP-3、∑MEHP-5与男孩胎盘重量呈正相关,母亲MEOHP、MEHHP、5cx-MEPP、∑MEHP-3、∑MEHP-5与女孩胎盘重量呈负相关。结论:我们的研究结果表明,父母在出生时接触邻苯二甲酸盐可能会对新生儿的胎儿生长和胎盘发育产生不利影响。然而,进一步研究更大的样本量和数据集是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship of parental phthalate exposure with fetal growth and placental development at birth.

Background: Prenatal exposure to phthalates is reported to influence fetal growth and may lead to lasting adverse effects on infants and their future development; yet, the results remain inconclusive.

Objective: This study utilized a birth cohort of 73 pregnant women-newborn pairs, including biological fathers (73 triads), to investigate the relationship between parental phthalate exposure during pregnancy and birth outcomes in newborns.

Methods: Demographic, behavioral, and clinical information, along with urine samples from both parents, were collected prior to delivery. Sixteen phthalate metabolites were quantified in urine samples.

Results: Significant correlations were observed between six phthalate metabolites (MEP, MiBP, MnBP, MBzP, MEHP, and 5cx-MEPP) in maternal urine and paternal levels. Maternal MBzP was positively associated with boys' birth weight, whereas maternal 2cx-MMHP was negatively associated with girls' birth weight. The ponderal index of boys was negatively related to maternal MBzP and MMP, but positively associated with ∑MEHP-3 and ∑MEHP-5 after adjusting for confounding variables. Among paternal phthalates, MBzP showed a negative association with boys' ponderal index, whereas MEP showed a positive association. Maternal MEOHP, ∑MEHP-3, and ∑MEHP-5 were positively associated with boys' placenta weight, while MEOHP, MEHHP, 5cx-MEPP, ∑MEHP-3, and ∑MEHP-5 were negatively associated with girls' placenta weight.

Conclusions: Our findings suggest that parental exposure to phthalates at birth may adversely affect fetal growth and placental development in neonates. However, further studies with larger sample sizes and datasets are necessary.

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来源期刊
Reproductive toxicology
Reproductive toxicology 生物-毒理学
CiteScore
6.50
自引率
3.00%
发文量
131
审稿时长
45 days
期刊介绍: Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.
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