COVID-19封锁下与健康相关的生活质量和QALY损失:以西班牙为例

IF 2.6 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
PLoS ONE Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI:10.1371/journal.pone.0329413
Mathieu F Janssen, Kim Rand, Anabel Estévez-Carrillo, Juan Manuel Ramos-Goñi
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引用次数: 0

摘要

2019冠状病毒病大流行迫使许多国家实施隔离措施,以限制病毒的传播。以质量调整生命年(QALYs)衡量损失,可为比较COVID-19的影响提供可比较的基础。本研究的目的是探讨COVID-19封锁的前21天对西班牙普通人群健康相关生活质量(HRQoL)和相关QALY损失的影响。方法:以配额为基础,分四批进行在线调查,每批500名普通人群受访者:一次在封锁前不久进行(基线),每周进行3次随访。HRQoL数据采用EQ-5D-5L采集。为了与疫情前的应对情况进行比较,我们以2011-2012年全国健康调查数据为参考。数据分析采用频率分析和逻辑回归。在随访期间和整个封锁期间估计了QALY损失。结果:将基线结果与随访结果进行比较,在随访期间,5个维度中报告的问题分布几乎没有变化。然而,焦虑/抑郁的结果显示,报告的问题比例增加了32%。在研究期间,西班牙人口估计总共积累了1,994,216个QALYs。根据参考数据,人口应该积累了2,0543737个QALYs,在21天内损失了60520个QALYs。在整个封锁期间,相应的损失将为285,310个QALYs。结论:在封锁情况下的人群报告的焦虑/抑郁问题发生率高于正常情况下的人群。在全国范围内,这可能导致质量年的重大损失,特别是在较长时间内。这是首次在全国范围内直接评估封锁对质量损失影响的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Health-related quality of life and QALY loss under COVID-19 lockdown: The case of Spain.

Health-related quality of life and QALY loss under COVID-19 lockdown: The case of Spain.

Health-related quality of life and QALY loss under COVID-19 lockdown: The case of Spain.

Health-related quality of life and QALY loss under COVID-19 lockdown: The case of Spain.

Health-related quality of life and QALY loss under COVID-19 lockdown: The case of Spain.

Health-related quality of life and QALY loss under COVID-19 lockdown: The case of Spain.

Health-related quality of life and QALY loss under COVID-19 lockdown: The case of Spain.

Objectives: The COVID-19 pandemic forced many countries to implement confinement measures to limit the spread of the virus. Measuring the loss in terms of quality-adjusted life-years (QALYs) may provide a commensurable basis for comparing the impact of COVID-19. The aim of this research was to explore the impact of the first 21 days of COVID-19 lockdown on health-related quality of life (HRQoL) and associated QALY loss of the Spanish general population.

Methods: A quota-based online survey was conducted in four waves with 500 general population respondents each: one conducted shortly before the lockdown (baseline) and 3 follow-ups conducted weekly. HRQoL data were collected using EQ-5D-5L. For comparison with pre-covid responses, data from the 2011-2012 National Health Survey was taken as reference. Data were analyzed using frequency analysis and logistic regression. QALY loss was estimated over the follow-up period and for the entire duration of the lockdown.

Results: Comparing the baseline results to the follow-up results shows little change with respect to the distributions of reported problems in any of the 5 dimensions during the follow-up period. However, results for anxiety/depression show a 32% increase in the proportion of reported problems. The Spanish population was estimated to accrue a total of 1,994,216 QALYs over the study period. Based on the reference data, the population should have accrued 2,054,737 QALYs, leading to a loss of 60,520 QALYs over 21 days. For the entire lockdown, the corresponding loss would be 285,310 QALYs.

Conclusions: A population under a lockdown situation reported higher rates of anxiety/depression problems than in a regular situation. On a country-wide scope, this may lead to a substantial loss in terms of QALYs, especially over longer periods of time. This is the first study to directly assess the impact of the lockdown in terms of QALY loss on a country-wide level.

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来源期刊
PLoS ONE
PLoS ONE 生物-生物学
CiteScore
6.20
自引率
5.40%
发文量
14242
审稿时长
3.7 months
期刊介绍: PLOS ONE is an international, peer-reviewed, open-access, online publication. PLOS ONE welcomes reports on primary research from any scientific discipline. It provides: * Open-access—freely accessible online, authors retain copyright * Fast publication times * Peer review by expert, practicing researchers * Post-publication tools to indicate quality and impact * Community-based dialogue on articles * Worldwide media coverage
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