Claudia R Morgado, Nicole B Larivoir, Juliana F Santos, Bianca Susanna, Lycia P Sampaio, Marcony R Santhiago
{"title":"OCT上皮行为标记物与地形上下不对称的相关性。","authors":"Claudia R Morgado, Nicole B Larivoir, Juliana F Santos, Bianca Susanna, Lycia P Sampaio, Marcony R Santhiago","doi":"10.3928/1081597X-20250606-03","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To explore the correlation between epithelial behavior markers derived from optical coherence tomography (OCT) and topographic inferior-superior asymmetry (I-S), and to compare these epithelial values across different I-S subgroups.</p><p><strong>Methods: </strong>In this prospective observational study, 526 eyes undergoing refractive surgery evaluation were randomly selected. Each patient underwent imaging examinations, including Placido-disk corneal topography and OCT. Four epithelial parameters-minimum (thinnest), maximum (thickest), difference between minimum and maximum, and standard deviation-were analyzed. Analysis of variance and Kruskal-Wallis tests compared these parameters across I-S subgroups, whereas Pearson correlation assessed the relationship between continuous I-S values and each epithelial parameter. Multiple linear regression evaluated the I-S predictive effect on epithelial metrics. Correlations were investigated considering the entire I-S spectrum and in two separate I-S subgroups (below and above 1.4).</p><p><strong>Results: </strong>Higher I-S values (I-S > 1.4) corresponded to significantly greater epithelial variability (difference between minimum and maximum, and standard deviation, <i>P</i> < .0001) compared to lower I-S groups. Across all I-S values, moderate, significant correlations were found between I-S and epithelial variability (difference, <i>r</i> = 0.57; standard deviation, <i>r</i> = 0.59; <i>P</i> < .0001). Subgroup analysis indicated that significant correlations between I-S and epithelial variability measures were present only in the high-asymmetry group (I-S > 1.4). Multiple linear regression confirmed that I-S significantly predicts epithelial variability, particularly in this subgroup.</p><p><strong>Conclusions: </strong>A moderate correlation exists between I-S and epithelial thickness variability, particularly in eyes with high asymmetry, as supported by regression analysis, indicating the predictive value of I-S. However, these epithelial markers are less useful in eyes with low asymmetry.</p>","PeriodicalId":16951,"journal":{"name":"Journal of refractive surgery","volume":"41 8","pages":"e776-e785"},"PeriodicalIF":3.0000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation Between Markers of Epithelial Behavior Derived From OCT and Topographic Inferior-Superior Asymmetry.\",\"authors\":\"Claudia R Morgado, Nicole B Larivoir, Juliana F Santos, Bianca Susanna, Lycia P Sampaio, Marcony R Santhiago\",\"doi\":\"10.3928/1081597X-20250606-03\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To explore the correlation between epithelial behavior markers derived from optical coherence tomography (OCT) and topographic inferior-superior asymmetry (I-S), and to compare these epithelial values across different I-S subgroups.</p><p><strong>Methods: </strong>In this prospective observational study, 526 eyes undergoing refractive surgery evaluation were randomly selected. Each patient underwent imaging examinations, including Placido-disk corneal topography and OCT. Four epithelial parameters-minimum (thinnest), maximum (thickest), difference between minimum and maximum, and standard deviation-were analyzed. Analysis of variance and Kruskal-Wallis tests compared these parameters across I-S subgroups, whereas Pearson correlation assessed the relationship between continuous I-S values and each epithelial parameter. Multiple linear regression evaluated the I-S predictive effect on epithelial metrics. Correlations were investigated considering the entire I-S spectrum and in two separate I-S subgroups (below and above 1.4).</p><p><strong>Results: </strong>Higher I-S values (I-S > 1.4) corresponded to significantly greater epithelial variability (difference between minimum and maximum, and standard deviation, <i>P</i> < .0001) compared to lower I-S groups. Across all I-S values, moderate, significant correlations were found between I-S and epithelial variability (difference, <i>r</i> = 0.57; standard deviation, <i>r</i> = 0.59; <i>P</i> < .0001). Subgroup analysis indicated that significant correlations between I-S and epithelial variability measures were present only in the high-asymmetry group (I-S > 1.4). Multiple linear regression confirmed that I-S significantly predicts epithelial variability, particularly in this subgroup.</p><p><strong>Conclusions: </strong>A moderate correlation exists between I-S and epithelial thickness variability, particularly in eyes with high asymmetry, as supported by regression analysis, indicating the predictive value of I-S. However, these epithelial markers are less useful in eyes with low asymmetry.</p>\",\"PeriodicalId\":16951,\"journal\":{\"name\":\"Journal of refractive surgery\",\"volume\":\"41 8\",\"pages\":\"e776-e785\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of refractive surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3928/1081597X-20250606-03\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of refractive surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/1081597X-20250606-03","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Correlation Between Markers of Epithelial Behavior Derived From OCT and Topographic Inferior-Superior Asymmetry.
Purpose: To explore the correlation between epithelial behavior markers derived from optical coherence tomography (OCT) and topographic inferior-superior asymmetry (I-S), and to compare these epithelial values across different I-S subgroups.
Methods: In this prospective observational study, 526 eyes undergoing refractive surgery evaluation were randomly selected. Each patient underwent imaging examinations, including Placido-disk corneal topography and OCT. Four epithelial parameters-minimum (thinnest), maximum (thickest), difference between minimum and maximum, and standard deviation-were analyzed. Analysis of variance and Kruskal-Wallis tests compared these parameters across I-S subgroups, whereas Pearson correlation assessed the relationship between continuous I-S values and each epithelial parameter. Multiple linear regression evaluated the I-S predictive effect on epithelial metrics. Correlations were investigated considering the entire I-S spectrum and in two separate I-S subgroups (below and above 1.4).
Results: Higher I-S values (I-S > 1.4) corresponded to significantly greater epithelial variability (difference between minimum and maximum, and standard deviation, P < .0001) compared to lower I-S groups. Across all I-S values, moderate, significant correlations were found between I-S and epithelial variability (difference, r = 0.57; standard deviation, r = 0.59; P < .0001). Subgroup analysis indicated that significant correlations between I-S and epithelial variability measures were present only in the high-asymmetry group (I-S > 1.4). Multiple linear regression confirmed that I-S significantly predicts epithelial variability, particularly in this subgroup.
Conclusions: A moderate correlation exists between I-S and epithelial thickness variability, particularly in eyes with high asymmetry, as supported by regression analysis, indicating the predictive value of I-S. However, these epithelial markers are less useful in eyes with low asymmetry.
期刊介绍：
The Journal of Refractive Surgery, the official journal of the International Society of Refractive Surgery, a partner of the American Academy of Ophthalmology, has been a monthly peer-reviewed forum for original research, review, and evaluation of refractive and lens-based surgical procedures for more than 30 years. Practical, clinically valuable articles provide readers with the most up-to-date information regarding advances in the field of refractive surgery. Begin to explore the Journal and all of its great benefits such as:
• Columns including “Translational Science,” “Surgical Techniques,” and “Biomechanics”
• Supplemental videos and materials available for many articles
• Access to current articles, as well as several years of archived content
• Articles posted online just 2 months after acceptance.
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