Yan Chen, Ruilan Gong, Qianzhu Li, Yina Wang, Lijun Wang, Xuanyang Wang
{"title":"NHANES 2005-2018中每日进食频率和夜间禁食持续时间与抑郁症之间的u型关联。","authors":"Yan Chen, Ruilan Gong, Qianzhu Li, Yina Wang, Lijun Wang, Xuanyang Wang","doi":"10.1016/j.jad.2025.120010","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Existing studies display certain limitations and inconsistencies regarding the association between daily eating frequency (DEF) and nighttime fasting duration (NFD) and depression. We examines the relationships between DEF, NFD, and depression.</p><p><strong>Methods: </strong>Among the 29,035 subjects in the National Health and Nutrition Examination Survey (NHANES) 2005-2018, depression is defined by a total Patient Health Questionnaire-9 (PHQ-9) score of at least 10. DEF is quantified through the number of eating instances, and NFD is evaluated by examining the day's first and last meals. Weighted logistic regression models, restricted cubic spline (RCS), and mediation analysis are performed.</p><p><strong>Results: </strong>In comparison to DEF between 3.6 and 4.0 times, subjects with DEF ≤ 3 times (OR 1.28, 95 % CI 1.11-1.49) and DEF ≥ 4.6 times (OR 1.17, 95 % CI 1.01-1.34) have a greater risk of depression. Relative to NFD ranging from 12.1 to 13.3 h, those with NFD ≤ 10.8 h (OR 1.32, 95 % CI 1.14-1.52) and NFD ≥ 14.9 h (OR 1.37, 95 % CI 1.19-1.59) are at increased risk of depression. The U-shaped smoothing curves for the association further validate the findings. Blood urea nitrogen (BUN) and globulin (Glo) play a mediating role in the association. Among subjects having a lower daily energy intake, the impact of DEF and NFD on depression is more significant (P<sub>interaction</sub> < 0.05).</p><p><strong>Conclusions: </strong>DEF ≤ 3 or ≥ 4.6 times and NFD ≤ 10.8 or ≥ 14.9 h are independently related to increased depression risk.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120010"},"PeriodicalIF":4.9000,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"U-shaped association between daily eating frequency and nighttime fasting duration and depression in NHANES 2005-2018.\",\"authors\":\"Yan Chen, Ruilan Gong, Qianzhu Li, Yina Wang, Lijun Wang, Xuanyang Wang\",\"doi\":\"10.1016/j.jad.2025.120010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Existing studies display certain limitations and inconsistencies regarding the association between daily eating frequency (DEF) and nighttime fasting duration (NFD) and depression. We examines the relationships between DEF, NFD, and depression.</p><p><strong>Methods: </strong>Among the 29,035 subjects in the National Health and Nutrition Examination Survey (NHANES) 2005-2018, depression is defined by a total Patient Health Questionnaire-9 (PHQ-9) score of at least 10. DEF is quantified through the number of eating instances, and NFD is evaluated by examining the day's first and last meals. Weighted logistic regression models, restricted cubic spline (RCS), and mediation analysis are performed.</p><p><strong>Results: </strong>In comparison to DEF between 3.6 and 4.0 times, subjects with DEF ≤ 3 times (OR 1.28, 95 % CI 1.11-1.49) and DEF ≥ 4.6 times (OR 1.17, 95 % CI 1.01-1.34) have a greater risk of depression. Relative to NFD ranging from 12.1 to 13.3 h, those with NFD ≤ 10.8 h (OR 1.32, 95 % CI 1.14-1.52) and NFD ≥ 14.9 h (OR 1.37, 95 % CI 1.19-1.59) are at increased risk of depression. The U-shaped smoothing curves for the association further validate the findings. Blood urea nitrogen (BUN) and globulin (Glo) play a mediating role in the association. Among subjects having a lower daily energy intake, the impact of DEF and NFD on depression is more significant (P<sub>interaction</sub> < 0.05).</p><p><strong>Conclusions: </strong>DEF ≤ 3 or ≥ 4.6 times and NFD ≤ 10.8 or ≥ 14.9 h are independently related to increased depression risk.</p>\",\"PeriodicalId\":14963,\"journal\":{\"name\":\"Journal of affective disorders\",\"volume\":\" \",\"pages\":\"120010\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of affective disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jad.2025.120010\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jad.2025.120010","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
U-shaped association between daily eating frequency and nighttime fasting duration and depression in NHANES 2005-2018.
Background: Existing studies display certain limitations and inconsistencies regarding the association between daily eating frequency (DEF) and nighttime fasting duration (NFD) and depression. We examines the relationships between DEF, NFD, and depression.
Methods: Among the 29,035 subjects in the National Health and Nutrition Examination Survey (NHANES) 2005-2018, depression is defined by a total Patient Health Questionnaire-9 (PHQ-9) score of at least 10. DEF is quantified through the number of eating instances, and NFD is evaluated by examining the day's first and last meals. Weighted logistic regression models, restricted cubic spline (RCS), and mediation analysis are performed.
Results: In comparison to DEF between 3.6 and 4.0 times, subjects with DEF ≤ 3 times (OR 1.28, 95 % CI 1.11-1.49) and DEF ≥ 4.6 times (OR 1.17, 95 % CI 1.01-1.34) have a greater risk of depression. Relative to NFD ranging from 12.1 to 13.3 h, those with NFD ≤ 10.8 h (OR 1.32, 95 % CI 1.14-1.52) and NFD ≥ 14.9 h (OR 1.37, 95 % CI 1.19-1.59) are at increased risk of depression. The U-shaped smoothing curves for the association further validate the findings. Blood urea nitrogen (BUN) and globulin (Glo) play a mediating role in the association. Among subjects having a lower daily energy intake, the impact of DEF and NFD on depression is more significant (Pinteraction < 0.05).
Conclusions: DEF ≤ 3 or ≥ 4.6 times and NFD ≤ 10.8 or ≥ 14.9 h are independently related to increased depression risk.
期刊介绍：
The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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