Joowon Chung, Jioh Kang, Sang Hoon Kim, Min Kyu Jung, Dong Hyun Kim, Hyun Joo Song, Ki Bae Kim, Seung-Joo Nam, Hoon Jai Chun, Jung Eun Lee, Yun Jeong Lim
{"title":"饮食中β-胡萝卜素、维生素A和视黄醇的摄入与结直肠腺瘤的发病率:一项横断面研究和荟萃分析","authors":"Joowon Chung, Jioh Kang, Sang Hoon Kim, Min Kyu Jung, Dong Hyun Kim, Hyun Joo Song, Ki Bae Kim, Seung-Joo Nam, Hoon Jai Chun, Jung Eun Lee, Yun Jeong Lim","doi":"10.5009/gnl250104","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aims: </strong>Antioxidants may offer protection against colorectal cancer, but their association with colorectal adenomas remains unclear due to variations in study design, population, and dietary factors. We investigated the relationship between dietary intake of β-carotene, vitamin A, and retinol and the prevalence of colorectal adenoma using food frequency questionnaires (FFQs) and colonoscopy data.</p><p><strong>Methods: </strong>We recruited participants undergoing elective colonoscopy across eight medical institutions. FFQs were administered prior to colonoscopy, and nutrient intakes were categorized into quartiles. Multivariate logistic regression was used to estimate odds ratios (ORs) adjusting for potential cofounders. A meta-analysis of 11 observational studies, including our own, was also conducted.</p><p><strong>Results: </strong>Among 720 eligible participants (mean age 52.44±14.30 years; body mass index 23.82±3.46 kg/m<sup>2</sup>), colorectal adenoma was identified in 266 (36.9%). Higher intake of β-carotene and vitamin A was associated with a significantly lower prevalence of colorectal adenoma (p for trend <0.05). Adjusted ORs for the highest versus lowest quartile were 0.43 (95% confidence interval [CI], 0.20 to 0.91) for β-carotene and 0.34 (95% CI, 0.15 to 0.76) for vitamin A. Conversely, higher retinol intake was linked to increased adenoma prevalence (OR, 2.16; 95% CI, 1.09 to 4.29), particularly among individuals with high-fat diets. Meta-analysis confirmed a protective association for β-carotene (OR, 0.60; 95% CI, 0.46 to 0.78), but not for vitamin A or retinol.</p><p><strong>Conclusions: </strong>We demonstrated an inverse association between β-carotene and colorectal adenoma prevalence, whereas the effects of vitamin A and retinol appeared to vary depending on dietary context. These findings highlight the complex influence of dietary pattern and nutrient sources on colorectal adenoma risk.</p>","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dietary β-Carotene, Vitamin A, and Retinol Intake and Prevalence of Colorectal Adenoma: A Cross-Sectional Study and Meta-Analysis.\",\"authors\":\"Joowon Chung, Jioh Kang, Sang Hoon Kim, Min Kyu Jung, Dong Hyun Kim, Hyun Joo Song, Ki Bae Kim, Seung-Joo Nam, Hoon Jai Chun, Jung Eun Lee, Yun Jeong Lim\",\"doi\":\"10.5009/gnl250104\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aims: </strong>Antioxidants may offer protection against colorectal cancer, but their association with colorectal adenomas remains unclear due to variations in study design, population, and dietary factors. We investigated the relationship between dietary intake of β-carotene, vitamin A, and retinol and the prevalence of colorectal adenoma using food frequency questionnaires (FFQs) and colonoscopy data.</p><p><strong>Methods: </strong>We recruited participants undergoing elective colonoscopy across eight medical institutions. FFQs were administered prior to colonoscopy, and nutrient intakes were categorized into quartiles. Multivariate logistic regression was used to estimate odds ratios (ORs) adjusting for potential cofounders. A meta-analysis of 11 observational studies, including our own, was also conducted.</p><p><strong>Results: </strong>Among 720 eligible participants (mean age 52.44±14.30 years; body mass index 23.82±3.46 kg/m<sup>2</sup>), colorectal adenoma was identified in 266 (36.9%). Higher intake of β-carotene and vitamin A was associated with a significantly lower prevalence of colorectal adenoma (p for trend <0.05). Adjusted ORs for the highest versus lowest quartile were 0.43 (95% confidence interval [CI], 0.20 to 0.91) for β-carotene and 0.34 (95% CI, 0.15 to 0.76) for vitamin A. Conversely, higher retinol intake was linked to increased adenoma prevalence (OR, 2.16; 95% CI, 1.09 to 4.29), particularly among individuals with high-fat diets. Meta-analysis confirmed a protective association for β-carotene (OR, 0.60; 95% CI, 0.46 to 0.78), but not for vitamin A or retinol.</p><p><strong>Conclusions: </strong>We demonstrated an inverse association between β-carotene and colorectal adenoma prevalence, whereas the effects of vitamin A and retinol appeared to vary depending on dietary context. 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Dietary β-Carotene, Vitamin A, and Retinol Intake and Prevalence of Colorectal Adenoma: A Cross-Sectional Study and Meta-Analysis.
Background/aims: Antioxidants may offer protection against colorectal cancer, but their association with colorectal adenomas remains unclear due to variations in study design, population, and dietary factors. We investigated the relationship between dietary intake of β-carotene, vitamin A, and retinol and the prevalence of colorectal adenoma using food frequency questionnaires (FFQs) and colonoscopy data.
Methods: We recruited participants undergoing elective colonoscopy across eight medical institutions. FFQs were administered prior to colonoscopy, and nutrient intakes were categorized into quartiles. Multivariate logistic regression was used to estimate odds ratios (ORs) adjusting for potential cofounders. A meta-analysis of 11 observational studies, including our own, was also conducted.
Results: Among 720 eligible participants (mean age 52.44±14.30 years; body mass index 23.82±3.46 kg/m2), colorectal adenoma was identified in 266 (36.9%). Higher intake of β-carotene and vitamin A was associated with a significantly lower prevalence of colorectal adenoma (p for trend <0.05). Adjusted ORs for the highest versus lowest quartile were 0.43 (95% confidence interval [CI], 0.20 to 0.91) for β-carotene and 0.34 (95% CI, 0.15 to 0.76) for vitamin A. Conversely, higher retinol intake was linked to increased adenoma prevalence (OR, 2.16; 95% CI, 1.09 to 4.29), particularly among individuals with high-fat diets. Meta-analysis confirmed a protective association for β-carotene (OR, 0.60; 95% CI, 0.46 to 0.78), but not for vitamin A or retinol.
Conclusions: We demonstrated an inverse association between β-carotene and colorectal adenoma prevalence, whereas the effects of vitamin A and retinol appeared to vary depending on dietary context. These findings highlight the complex influence of dietary pattern and nutrient sources on colorectal adenoma risk.
期刊介绍:
Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology.
Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.