omega-3脂肪酸对骨骼肌血管健康和代谢的影响。

IF 3.5 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Elmira Karimi, Michelle A Keske, Mohammad Beba, Gunveen Kaur
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引用次数: 0

摘要

综述目的:本综述旨在总结omega-3脂肪酸(FAs)对骨骼肌血管和代谢健康影响的最新发现。我们特别关注大血管(大血管)结果,骨骼肌微血管(毛细血管)血流和骨骼肌健康和代谢。最近的发现:最近的荟萃分析和干预研究表明,omega-3脂肪酸通过增强内皮功能、减少动脉僵硬和提高一氧化氮的生物利用度来改善人类大血管健康结果。然而,与健康个体相比,临床人群对大血管预后的益处更为明显。在剂量方面,超过1克/天的omega-3脂肪酸似乎比少于1克/天更有益。与大血管结果相反,omega-3脂肪酸对骨骼肌微血管结果的影响仍未确定,表明该领域存在重大空白。在骨骼肌健康和新陈代谢方面,omega-3脂肪酸可以改善健康人的肌肉力量和餐后血糖水平。omega-3脂肪酸的抗炎作用似乎也有益于肌肉健康和新陈代谢。总结:Omega-3脂肪酸对大血管结局、肌肉代谢和健康有积极作用,特别是在临床人群中。在健康人群和临床人群中,omega-3脂肪酸对肌肉微血管结果的直接影响有待确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of omega-3 fatty acids on skeletal muscle vascular health and metabolism.

Purpose of review: This review aims to summarise recent findings on the effects of omega-3 fatty acids (FAs) on skeletal muscle vascular and metabolic health. We particularly focus on macrovascular (large blood vessel) outcomes, skeletal muscle microvascular (capillary) blood flow and skeletal muscle health and metabolism.

Recent findings: Recent meta-analysis and intervention studies suggest that omega-3 FAs improve macrovascular health outcomes in humans by enhancing endothelial function, reducing arterial stiffness and by increasing nitric oxide bioavailability. However, the benefits on macrovascular outcomes are more evident in clinical populations than in healthy individuals. In terms of dose, more than 1 g/day of omega-3 FA appear to be more beneficial than less than 1 g/day. In contrast to macrovascular outcomes, the effect of omega-3 FAs on skeletal muscle microvascular outcomes remains undetermined, demonstrating a significant gap in the field. In terms of skeletal muscle health and metabolism, omega-3 FAs improve muscle strength and ameliorate postprandial blood glucose levels in healthy individuals. The anti-inflammatory effects of omega-3 FAs also appear to benefit muscle health and metabolism.

Summary: Omega-3 FAs have a positive effect on macrovascular outcomes, muscle metabolism and health, specifically in clinical populations. The direct effects of omega-3 FAs on muscle microvascular outcomes in both healthy and clinical populations need to be determined.

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来源期刊
CiteScore
5.30
自引率
6.50%
发文量
116
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Clinical Nutrition and Metabolic Care offers a broad-based perspective on the most recent and exciting developments within the field of clinical nutrition and metabolic care. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include protein, amino acid metabolism and therapy, lipid metabolism and therapy, nutrition and the intensive care unit and carbohydrates. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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