在COVID-19时代之前和期间,医院和非医院发生的产kpc肺炎克雷伯菌感染的发病率、临床和基因组趋势:一项为期十年的中断时间序列研究

IF 4.4 2区 医学 Q1 INFECTIOUS DISEASES
Manuel Recio-Rufián, Teresa López-Viñau, Víctor Gálvez-Soto, Ángela Cano, Rafael Ruiz-Montero, Belén Gutiérrez-Gutiérrez, Irene Gracia-Ahufinger, Germán Peñalva, Juan Antonio Marín-Sanz, Miriam Marín-Sanz, David Segorbe, Juan Jesús Pineda-Capitán, Montserrat Muñoz-Rosa, Cristina Riazzo, Federico Giovagnorio, Elisa Ruiz-Arabi, José David Torres-Peña, Juan José Castón, Isabel Machuca, Inmaculada Salcedo-Leal, Luis Martínez-Martínez, Elena Pérez-Nadales, Julián Torre-Cisneros
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引用次数: 0

摘要

背景:由产kpc肺炎克雷伯菌(KPC-KP)引起的感染是一个持续的公共卫生挑战。本前瞻性研究调查了2012年爆发后医院发病(HOI)和非医院发病(非HOI,包括医疗保健相关[HcAI]和社区获得性[CA])的KPC-KP感染的十年趋势、临床特征和基因组流行病学。我们评估了2014年抗菌药物管理计划(ASP)和covid -19相关感染预防和控制(IPC)措施的影响,重点是医院到社区的传播。方法:我们分析了一家三级转诊医院的前瞻性纵向队列患者(2012-2022)。中断时间序列和ARIMA模型评估了ASP和IPC对发病率密度(ID)的影响。交叉相关分析探讨了HOI和非HOI趋势之间的时间关联。全基因组测序和PERMANOVA分析了ST512/KPC-3分离株的基因组结构。多变量回归分析了感染类型与临床结果的关系。结果:467例患者中,非HOI占33.2% (ID 0.53/ 1000入院/月),HOI占66.8% (ID 0.30, p = 0.39)。非HOI患者以尿路感染为主(52.9%),而HOI患者以血流和呼吸道感染为主。实施ASP后,HOI和非HOI感染的发生率密度显著下降,4个月的滞后表明了连续的传播动态。在大流行期间保持了这些减少。基因组数据证实了ST512/KPC-3的优势和医院到社区的传播,时间因素-而不是获得类型-解释了遗传变异。调整后的分析显示,HOI和非HOI的30天死亡率和治疗反应相似。结论:ASP和COVID-19 IPC措施有助于维持较低的KPC-KP发病率。基因组证据强调了时间动态和克隆扩增在ST512/KPC-3传播中的作用。非hoi感染具有临床意义,需要有针对性的全系统监测和控制战略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted time series study.

Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted time series study.

Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted time series study.

Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted time series study.

Background: Infections caused by KPC-producing Klebsiella pneumoniae (KPC-KP) represent a persistent public health challenge. This prospective study examines ten-year trends, clinical features, and genomic epidemiology of hospital-onset (HOI) and non-hospital-onset (non-HOI, including healthcare-associated [HcAI] and community-acquired [CA]) KPC-KP infections following a 2012 outbreak. We evaluated the impacts of a 2014 antimicrobial stewardship program (ASP) and COVID-19-related infection prevention and control (IPC) measures, with emphasis on hospital-to-community dissemination.

Methods: We analysed a prospective, longitudinal cohort of patients (2012-2022) in a tertiary referral hospital. Interrupted time series and ARIMA models assessed ASP and IPC impacts on incidence density (ID). Cross-correlation analysis explored temporal associations between HOI and non-HOI trends. Whole-genome sequencing and PERMANOVA evaluated the genomic structure of ST512/KPC-3 isolates. Multivariable regression analysed the association between infection type and clinical outcomes.

Results: Among 467 patients, 33.2% had non-HOI (ID 0.53/1,000 admissions/month) and 66.8% HOI (ID 0.30, p = 0.39). Urinary tract infections predominated in non-HOI (52.9%), while bloodstream and respiratory infections were more common in HOI. Incidence density of HOI and non-HOI infections declined significantly following ASP implementation, with a 4-month lag suggesting sequential transmission dynamics. These reductions were maintained during the pandemic. Genomic data confirmed ST512/KPC-3 dominance and hospital-to-community spread, with temporal factors-rather than acquisition type-explaining genetic variation. Adjusted analyses showed similar 30-day mortality and treatment responses across HOI and non-HOI.

Conclusions: ASP and COVID-19 IPC measures contributed to maintaining low KPC-KP incidence. Genomic evidence underscores the role of temporal dynamics and clonal expansion in ST512/KPC-3 dissemination. Non-HOI infections are clinically significant and require targeted, system-wide surveillance and control strategies.

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来源期刊
Antimicrobial Resistance and Infection Control
Antimicrobial Resistance and Infection Control PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES
CiteScore
9.70
自引率
3.60%
发文量
140
审稿时长
13 weeks
期刊介绍: Antimicrobial Resistance and Infection Control is a global forum for all those working on the prevention, diagnostic and treatment of health-care associated infections and antimicrobial resistance development in all health-care settings. The journal covers a broad spectrum of preeminent practices and best available data to the top interventional and translational research, and innovative developments in the field of infection control.
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