Rene Bilingwe Ayiseh, Fobang Ulrick Anangafack, Judith Christine Etaka, Gamua Stanley Dobgima, Chrysantus Njobinkir Bimela, Stephen Mbigha Ghogomu, Fidelis Cho-Ngwa
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No prior experimental studies have established a causal relationship between onchocerciasis and epilepsy.</p>\n \n <span>AbstractSection</span>\n Methods\n <p>Gerbils were surgically implanted with <i>O. ochengi</i> worm masses (test group) or underwent sham operations (control group) to assess the infection’s effects. Survival rates were monitored post-implantation, and behavioral assessments were conducted on days 15–19 using the elevated plus maze, open-field, object recognition, and hanging wire tests. On day 21, the gerbils were sacrificed, and their body and organ weights were recorded, along with an analysis of worm mass survival.</p>\n \n <span>AbstractSection</span>\n Results\n <p>Implantation of 15 worm masses resulted in 100% mortality in the test group. When 10 worm masses were implanted, 53.3% of gerbils died, while all control gerbils survived. By day 21, an average of 1.4 out of 10 implanted worm masses remained viable, with a viability score of 93.3%. Test gerbils exhibited significant reductions in overall body weight and increased spleen weight compared to controls. However, behavioral tests revealed no significant differences between the two groups.</p>\n \n <span>AbstractSection</span>\n Conclusion\n <p>While <i>O. ochengi</i> worm masses caused notable physical effects, including increased mortality and altered body and organ weights, no conclusive evidence was found linking the infection to behavioral changes indicative of epilepsy. Further research is necessary to explore the potential association between onchocerciasis and epilepsy development.</p>\n \n </div>","PeriodicalId":6932,"journal":{"name":"Acta Parasitologica","volume":"70 4","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Physiological and Behavioral Effects of Onchocerca ochengi Infection in Gerbils: Implications for Onchocerciasis-Associated Epilepsy Research\",\"authors\":\"Rene Bilingwe Ayiseh, Fobang Ulrick Anangafack, Judith Christine Etaka, Gamua Stanley Dobgima, Chrysantus Njobinkir Bimela, Stephen Mbigha Ghogomu, Fidelis Cho-Ngwa\",\"doi\":\"10.1007/s11686-025-01105-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <span>AbstractSection</span>\\n Purpose\\n <p>This study aimed to investigate whether <i>Onchocerca ochengi</i> infection directly causes epilepsy. Although <i>O. ochengi</i>—a cattle parasite phylogenetically related to <i>O. volvulus</i>—shares biological similarities with its human counterpart, it has not been epidemiologically linked to epilepsy in bovines, unlike <i>O. volvulus</i>, which has been associated with onchocerciasis-associated epilepsy in humans. No prior experimental studies have established a causal relationship between onchocerciasis and epilepsy.</p>\\n \\n <span>AbstractSection</span>\\n Methods\\n <p>Gerbils were surgically implanted with <i>O. ochengi</i> worm masses (test group) or underwent sham operations (control group) to assess the infection’s effects. Survival rates were monitored post-implantation, and behavioral assessments were conducted on days 15–19 using the elevated plus maze, open-field, object recognition, and hanging wire tests. On day 21, the gerbils were sacrificed, and their body and organ weights were recorded, along with an analysis of worm mass survival.</p>\\n \\n <span>AbstractSection</span>\\n Results\\n <p>Implantation of 15 worm masses resulted in 100% mortality in the test group. When 10 worm masses were implanted, 53.3% of gerbils died, while all control gerbils survived. By day 21, an average of 1.4 out of 10 implanted worm masses remained viable, with a viability score of 93.3%. Test gerbils exhibited significant reductions in overall body weight and increased spleen weight compared to controls. However, behavioral tests revealed no significant differences between the two groups.</p>\\n \\n <span>AbstractSection</span>\\n Conclusion\\n <p>While <i>O. ochengi</i> worm masses caused notable physical effects, including increased mortality and altered body and organ weights, no conclusive evidence was found linking the infection to behavioral changes indicative of epilepsy. 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引用次数: 0
摘要
【摘要】【章节】目的探讨盘尾丝虫感染是否直接引起癫痫。虽然ocheno -一种在系统发育上与回旋O.相关的牛寄生虫-与其人类同类在生物学上有相似之处，但在流行病学上，它与牛的癫痫没有联系，不像回旋O.与盘尾丝虫病相关的人类癫痫。此前没有实验研究证实盘尾丝虫病与癫痫之间存在因果关系。【摘要】方法采用沙鼠手术植入奥氏弧菌虫块（试验组）或假手术（对照组），观察感染效果。植入后监测存活率，并在第15-19天使用高架迷宫、露天场地、物体识别和挂线测试进行行为评估。第21天处死沙鼠，记录其身体和器官重量，并分析虫体存活率。【摘要】【结果】实验组植入术15例，死亡率100%。植入10个虫块后，53.3%的沙鼠死亡，而对照组沙鼠全部存活。到第21天，10个植入虫团中平均有1.4个存活，存活评分为93.3%。与对照组相比，沙鼠表现出总体体重的显著减少和脾脏重量的增加。然而，行为测试显示两组之间没有显著差异。结论虽然ochengi O. ochengi虫团引起了显著的身体影响，包括死亡率增加和身体和器官重量的改变，但没有确凿的证据表明感染与癫痫的行为改变有关。盘尾丝虫病与癫痫发展之间的潜在联系有待进一步研究。
Physiological and Behavioral Effects of Onchocerca ochengi Infection in Gerbils: Implications for Onchocerciasis-Associated Epilepsy Research
AbstractSection
Purpose
This study aimed to investigate whether Onchocerca ochengi infection directly causes epilepsy. Although O. ochengi—a cattle parasite phylogenetically related to O. volvulus—shares biological similarities with its human counterpart, it has not been epidemiologically linked to epilepsy in bovines, unlike O. volvulus, which has been associated with onchocerciasis-associated epilepsy in humans. No prior experimental studies have established a causal relationship between onchocerciasis and epilepsy.
AbstractSection
Methods
Gerbils were surgically implanted with O. ochengi worm masses (test group) or underwent sham operations (control group) to assess the infection’s effects. Survival rates were monitored post-implantation, and behavioral assessments were conducted on days 15–19 using the elevated plus maze, open-field, object recognition, and hanging wire tests. On day 21, the gerbils were sacrificed, and their body and organ weights were recorded, along with an analysis of worm mass survival.
AbstractSection
Results
Implantation of 15 worm masses resulted in 100% mortality in the test group. When 10 worm masses were implanted, 53.3% of gerbils died, while all control gerbils survived. By day 21, an average of 1.4 out of 10 implanted worm masses remained viable, with a viability score of 93.3%. Test gerbils exhibited significant reductions in overall body weight and increased spleen weight compared to controls. However, behavioral tests revealed no significant differences between the two groups.
AbstractSection
Conclusion
While O. ochengi worm masses caused notable physical effects, including increased mortality and altered body and organ weights, no conclusive evidence was found linking the infection to behavioral changes indicative of epilepsy. Further research is necessary to explore the potential association between onchocerciasis and epilepsy development.
期刊介绍：
Acta Parasitologica is an international journal covering the latest advances in the subject.
Acta Parasitologica publishes original papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in biochemical and molecular biology of parasites, their physiology, morphology, taxonomy and ecology, as well as original research papers on immunology, pathology, and epidemiology of parasitic diseases in the context of medical, veterinary and biological sciences. The journal also publishes short research notes, invited review articles, book reviews.
The journal was founded in 1953 as "Acta Parasitologica Polonica" by the Polish Parasitological Society and since 1954 has been published by W. Stefanski Institute of Parasitology of the Polish Academy of Sciences in Warsaw. Since 1992 in has appeared as Acta Parasitologica in four issues per year.
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