长效给药系统：现状与未来展望。

IF 7.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-08-05 DOI:10.1016/j.drudis.2025.104447

Eneko Larrañeta , Juan Domínguez-Robles

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引用次数: 0

摘要

常规给药往往导致药物水平波动和疗效降低，特别是在需要持续治疗的慢性疾病中。长效给药系统（LADDS）提供可控的延长释放，提高疗效、安全性和患者依从性。这篇综述概述了目前可注射和可植入的LADDS，包括已批准的配方，如纳米悬浮液、PLGA微球、油基注射、原位成型和预成型植入物。未来的研究方向是热响应凝胶、聚合物药物偶联物、前药、3D打印和使用半透膜的储层型植入物。这些创新突出了继续开展多学科合作以推进下一代长效疗法的必要性。

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Long-acting drug delivery systems: Current landscape and future prospects

Conventional drug delivery often leads to fluctuating drug levels and reduced efficacy, especially in chronic conditions requiring sustained treatment. Long-acting drug delivery systems (LADDS) offer controlled, extended release, improving efficacy, safety, and patient adherence. This mini review outlines current injectable and implantable LADDS, including approved formulations like nanosuspensions, PLGA microspheres, oil-based injections, in situ-forming and preformed implants. Future directions explore thermoresponsive gels, polymer-drug conjugates, prodrugs, 3D printing, and reservoir-type implants using semipermeable membranes. These innovations highlight the need for continued multidisciplinary collaboration to advance next-generation long-acting therapies.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.