FXR拮抗查尔酮的结构修饰及其对非小细胞肺癌细胞增殖和转移的抑制作用

IF 3.4 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-08-08 DOI:10.1002/cmdc.202500625

引用次数: 0

摘要

图11B包含一些重复的培养皿图像。通过对原始数据的仔细检查和比较，我们发现了H460-6p 20 μM和H1975-GS 50 μM，H460-6p 10 μM和H1975-6p 20 μM，H1975-CON和H1299-6p 5 μM的重复图像。请将H460-6p 20 μM、H1975-CON、H1975-GS 50 μM、H1975-6p 20 μM的图像替换为正确的图像。新的图11如下所示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis

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Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis

Figure 11B contains some duplicate Petri dish images. After careful examination and comparison with the original data, we found duplicate images for the following pairs:

H460-6p 20 μM and H1975-GS 50 μM,

H460-6p 10 μM and H1975-6p 20 μM,

H1975-CON and H1299-6p 5 μM.

These have been corrected by replacing the images for H460-6p 20 μM, H1975-CON, H1975-GS 50 μM, and H1975-6p 20 μM with the proper images. The new Figure 11 is shown below.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.