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pd催化氧化脱氢和c2选择性芳基化一步法合成2-芳酰吲哚。

IF 4.6 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
RSC Advances Pub Date : 2025-08-07 eCollection Date: 2025-08-01 DOI:10.1039/d5ra04628a
Yo-Sep Yang, Jiyeon Yoo, Juhyeon Jeon, Jun Hwi Bak, Jeong-Won Shin, Hyuck-Jae Won, Hee Sung Hwang, Ju Hee Kim, Jaehoon Sim, Nam-Jung Kim
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引用次数: 0

摘要

我们报道了一种由吲哚类化合物通过pd催化氧化脱氢和连续的c2区域选择性heck型反应一步合成2-芳基吲哚的有效方法。在以O2为唯一氧化剂的温和反应条件下，反应底物范围广，官能团相容性好。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

One-step synthesis of 2-arylindoles from indolines <i>via</i> Pd-catalyzed oxidative dehydrogenation and C2-selective arylation.

One-step synthesis of 2-arylindoles from indolines <i>via</i> Pd-catalyzed oxidative dehydrogenation and C2-selective arylation.

One-step synthesis of 2-arylindoles from indolines <i>via</i> Pd-catalyzed oxidative dehydrogenation and C2-selective arylation.

One-step synthesis of 2-arylindoles from indolines <i>via</i> Pd-catalyzed oxidative dehydrogenation and C2-selective arylation.

One-step synthesis of 2-arylindoles from indolines <i>via</i> Pd-catalyzed oxidative dehydrogenation and C2-selective arylation.

One-step synthesis of 2-arylindoles from indolines <i>via</i> Pd-catalyzed oxidative dehydrogenation and C2-selective arylation.

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One-step synthesis of 2-arylindoles from indolines via Pd-catalyzed oxidative dehydrogenation and C2-selective arylation.

We report an efficient synthetic approach to 2-arylindoles from indolines via a one-step process involving Pd-catalyzed oxidative dehydrogenation and a sequential C2-regioselective Heck-type reaction. The mild reaction conditions, which utilize O2 as the sole oxidant, show a broad substrate scope and good functional group compatibility.

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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍： An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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