{"title":"锰掺杂锌介导的金纳米团簇组装作为双发射荧光探针用于复杂生物流体中生物硫醇的表面控制比例检测。","authors":"Santanu Dolai, and , Srestha Basu*, ","doi":"10.1021/acs.langmuir.5c03016","DOIUrl":null,"url":null,"abstract":"<p >We developed a ratiometric fluorescent probe using zinc-mediated assemblies of Mn<sup>2+</sup>-doped gold nanoclusters for the sensitive detection of biologically relevant thiols. Thiol binding selectively enhanced the nanoclusters's emission at 477 nm, while Mn<sup>2+</sup> emission at 570 nm remained unaltered, enabling precise ratiometric sensing. The probe showed performance in complex media, like blood serum, and showed high selectivity, with no allied response to non-thiol analogues. This platform offers a reliable and practical tool for thiol detection under physiological conditions.</p>","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"41 32","pages":"21838–21845"},"PeriodicalIF":3.9000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Manganese-Doped Zinc-Mediated Assembly of Gold Nanoclusters as a Dual-Emitting Fluorescent Probe for Surface-Controlled Ratiometric Detection of Biothiols in Complex Biofluids\",\"authors\":\"Santanu Dolai, and , Srestha Basu*, \",\"doi\":\"10.1021/acs.langmuir.5c03016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >We developed a ratiometric fluorescent probe using zinc-mediated assemblies of Mn<sup>2+</sup>-doped gold nanoclusters for the sensitive detection of biologically relevant thiols. Thiol binding selectively enhanced the nanoclusters's emission at 477 nm, while Mn<sup>2+</sup> emission at 570 nm remained unaltered, enabling precise ratiometric sensing. The probe showed performance in complex media, like blood serum, and showed high selectivity, with no allied response to non-thiol analogues. This platform offers a reliable and practical tool for thiol detection under physiological conditions.</p>\",\"PeriodicalId\":50,\"journal\":{\"name\":\"Langmuir\",\"volume\":\"41 32\",\"pages\":\"21838–21845\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Langmuir\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.langmuir.5c03016\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Langmuir","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.langmuir.5c03016","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Manganese-Doped Zinc-Mediated Assembly of Gold Nanoclusters as a Dual-Emitting Fluorescent Probe for Surface-Controlled Ratiometric Detection of Biothiols in Complex Biofluids
We developed a ratiometric fluorescent probe using zinc-mediated assemblies of Mn2+-doped gold nanoclusters for the sensitive detection of biologically relevant thiols. Thiol binding selectively enhanced the nanoclusters's emission at 477 nm, while Mn2+ emission at 570 nm remained unaltered, enabling precise ratiometric sensing. The probe showed performance in complex media, like blood serum, and showed high selectivity, with no allied response to non-thiol analogues. This platform offers a reliable and practical tool for thiol detection under physiological conditions.
期刊介绍:
Langmuir is an interdisciplinary journal publishing articles in the following subject categories:
Colloids: surfactants and self-assembly, dispersions, emulsions, foams
Interfaces: adsorption, reactions, films, forces
Biological Interfaces: biocolloids, biomolecular and biomimetic materials
Materials: nano- and mesostructured materials, polymers, gels, liquid crystals
Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry
Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals
However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do?
Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*.
This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).