长期悲伤障碍的大规模脑网络连接中断:与悲伤相关的回避、向往和侵入性思想的关系。

IF 4.8
Nutta-On P Blair, Gyujoon Hwang, B Douglas Ward, Stacy A Claesges, Abigail R Webber, Keri R Hainsworth, Yang Wang, Charles F Reynolds, Elliot A Stein, Joseph S Goveas
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引用次数: 0

摘要

背景:大规模的脑网络功能障碍与多种神经精神疾病有关。这些网络之间相互作用的中断可能同样是延长悲伤障碍(PGD)的关键症状的基础。方法:在一项横断面功能磁共振成像研究中,比较了大规模网络之间的静息状态功能连通性(rsFC)在人口统计学和自损失等效的可能PGD的老年人(n=42)和综合悲伤的老年人(n=45)之后的时间。组独立分量分析显示了多个网络,其中8个(显著性、默认模式、左右执行控制、腹侧注意、背侧注意、感觉运动和视觉)被选中进行进一步分析,并计算了所有网络对之间的rsFC强度。使用低频波动分数幅度(fALFF)进一步评估具有显著组差异的网络,以确定网络内部差异。在PGD和综合悲伤组中,独立探索连通性测量与临床症状之间的关系。结果:与综合悲伤(pcorrected = 0.014)相比,PGD中显著性(SN)和默认模式(DMN)网络之间的rsFC更高,且与悲伤严重程度(pcorrected = 0.04)和悲伤相关回避(pcorrected = 0.04)呈正相关。在PGD中,DMN中观察到较高的fALFF(校正后= 0.04),但SN中没有。主成分分析揭示了四个症状维度,多个大脑网络之间的连通性延伸到SN和DMN之外,与侵入性思想/向往/回避成分相关。结论:SN和DMN之间的异常连接似乎是PGD中悲伤严重程度和回避的神经生物学相关。更广泛的网络间连接中断与侵入性思想、渴望和回避有关,这就需要进一步研究脑网络功能障碍在PGD中的机制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Disrupted Large-Scale Brain Network Connectivity in Prolonged Grief Disorder: Relationship with Grief-Related Avoidance, Yearning, and Intrusive Thoughts.

Background: Large-scale brain network dysfunctions have been implicated in multiple neuropsychiatric disorders. Disrupted interactions between these networks may similarly underlie key symptoms in prolonged grief disorder (PGD).

Methods: In a cross-sectional, functional magnetic resonance imaging study, resting-state functional connectivity (rsFC) between large-scale networks were compared in demographic- and time since loss-equated older adults with probable PGD (n=42) and those with integrated grief (n=45). Group independent component analysis revealed multiple networks, eight of which (salience, default mode, left and right executive control, ventral attention, dorsal attention, sensorimotor, and visual) were selected for further analyses, with rsFC strength between all network pairs computed. Networks with significant group differences were further assessed using fractional amplitude of low-frequency fluctuations (fALFF) to determine within-network differences. The relationships between connectivity measures and clinical symptoms were explored independently in the PGD and integrated grief groups.

Results: Higher rsFC between the salience (SN) and default mode (DMN) networks was observed in PGD compared with integrated grief (pcorrected = 0.014), which positively correlated with grief severity (pcorrected = 0.04) and grief-related avoidance (pcorrected = 0.04). In PGD, higher fALFF was observed in the DMN (puncorrected = 0.04), but not the SN. Principal component analysis revealed four symptom dimensions, with connectivity between multiple brain networks extending beyond SN and DMN associated with an intrusive thoughts/yearning/avoidance component.

Conclusions: Aberrant connectivity between the SN and DMN appears to be a neurobiological correlate of grief severity and avoidance in PGD. Broader between-network connectivity disruptions correlate with intrusive thoughts, yearning, and avoidance, warranting further investigations into the mechanistic role of brain network dysfunction in PGD.

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