Ting-Fu Lai, Jong-Hwan Park, Minwoo Jang, Jiaren Chen, Myung-Jun Shin, Eunsoo Moon, Jung Mo Kang, Jong Won Lee, Yoon Jae Cho, Yung Liao, Tae Sik Goh, Jung Sub Lee
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This study aimed to investigate the joint association of PhA and ECW/TBW status with poor muscle function in middle-aged and older adults.</p><p><strong>Methods: </strong>This cross-sectional study included 695 community-dwelling adults aged ≥ 50 years (mean age 75.7 ± 8.9 years; 21.4% male; mean BMI 24.6 ± 3.6 kg/m<sup>2</sup>). PhA and ECW/TBW were measured using a BWA 2.0 Body Water Analyzer (InBody BWA, Inc. Audubon, PA, USA) in a seated position. Participants were categorized into three groups based on their PhA and ECW/TBW status: Normal PhA/Normal ECW/TBW (<i>n</i> = 258), Normal PhA/Elevated ECW/TBW (<i>n</i> = 323), and Lower PhA/Elevated ECW/TBW (<i>n</i> = 114). Logistic regression was used to assess the association with low physical function (Short Physical Performance Battery score ≤ 9) and low grip strength.</p><p><strong>Results: </strong>After adjustment for demographic and clinical confounders, the Lower PhA/Elevated ECW/TBW group showed significant associations with both low physical function (OR = 3.07, 95% CI = 1.63-5.81) and low grip strength (OR = 2.41, 95% CI = 1.20-4.85), as well as their co-occurrence (OR = 3.10, 95% CI = 1.53-6.27). No significant associations were found for the Normal PhA/Elevated ECW/TBW group after adjustment.</p><p><strong>Conclusion: </strong>The combination of a lower PhA and an elevated ECW/TBW ratio is significantly associated with poor muscle function. This combined BIA profile may serve as a useful, noninvasive screening tool for identifying individuals at high risk of functional decline in community settings.</p>","PeriodicalId":17400,"journal":{"name":"Journal of the International Society of Sports Nutrition","volume":"22 1","pages":"2536693"},"PeriodicalIF":3.9000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332989/pdf/","citationCount":"0","resultStr":"{\"title\":\"Elevated extracellular water to total body water ratio and low phase angle in relation to muscle function in middle-aged and older adults.\",\"authors\":\"Ting-Fu Lai, Jong-Hwan Park, Minwoo Jang, Jiaren Chen, Myung-Jun Shin, Eunsoo Moon, Jung Mo Kang, Jong Won Lee, Yoon Jae Cho, Yung Liao, Tae Sik Goh, Jung Sub Lee\",\"doi\":\"10.1080/15502783.2025.2536693\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Decline in muscle function is a major health concern in aging populations, increasing the risk for disability and frailty. 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引用次数: 0
摘要
背景：肌肉功能下降是老龄化人群的主要健康问题，增加了残疾和虚弱的风险。生物电阻抗分析（BIA）提供了一种实用的方法来评估社区环境下的生理状态。bia衍生的参数包括相角（PhA），这是细胞健康和完整性的指标，以及反映液体平衡和全身炎症的细胞外水/全身水（ECW/TBW）比率。目的：虽然这些标志物与不良健康结果独立相关，但它们在区分功能衰退风险方面的综合效用仍未得到充分探索。本研究旨在探讨PhA和ECW/TBW状态与中老年人肌肉功能不良的联合关系。方法：本横断面研究纳入695名年龄≥50岁的社区居民(平均年龄75.7±8.9岁；男性21.4%;平均BMI为24.6±3.6 kg/m2)。PhA和ECW/TBW采用BWA 2.0 Body Water Analyzer （InBody BWA, Inc.）测量。奥杜邦，宾夕法尼亚州，美国)。参与者根据他们的PhA和ECW/TBW状态分为三组：正常PhA/正常ECW/TBW (n = 258)，正常PhA/升高ECW/TBW （n = 323）和低PhA/升高ECW/TBW （n = 114）。采用Logistic回归来评估低身体机能（Short physical Performance Battery评分≤9）和低握力之间的关系。结果：在调整了人口统计学和临床混杂因素后，低PhA/高ECW/TBW组与低身体功能（OR = 3.07, 95% CI = 1.63-5.81）和低握力（OR = 2.41, 95% CI = 1.20-4.85）及其共发生（OR = 3.10, 95% CI = 1.53-6.27）均有显著相关性。调整后正常PhA/升高ECW/TBW组无显著相关性。结论：PhA降低和ECW/TBW比值升高与肌肉功能低下显著相关。这种联合BIA谱可以作为一种有用的、无创的筛查工具，用于识别社区环境中功能衰退高风险个体。
Elevated extracellular water to total body water ratio and low phase angle in relation to muscle function in middle-aged and older adults.
Background: Decline in muscle function is a major health concern in aging populations, increasing the risk for disability and frailty. Bioelectrical impedance analysis (BIA) offers a practical method to assess physiological status in community settings. BIA-derived parameters include the phase angle (PhA), an indicator of cellular health and integrity, and the extracellular water to total body water (ECW/TBW) ratio, which reflects fluid balance and systemic inflammation. Objective: While these markers have been independently linked to adverse health outcomes, their combined utility for stratifying the risk of functional decline remains underexplored. This study aimed to investigate the joint association of PhA and ECW/TBW status with poor muscle function in middle-aged and older adults.
Methods: This cross-sectional study included 695 community-dwelling adults aged ≥ 50 years (mean age 75.7 ± 8.9 years; 21.4% male; mean BMI 24.6 ± 3.6 kg/m2). PhA and ECW/TBW were measured using a BWA 2.0 Body Water Analyzer (InBody BWA, Inc. Audubon, PA, USA) in a seated position. Participants were categorized into three groups based on their PhA and ECW/TBW status: Normal PhA/Normal ECW/TBW (n = 258), Normal PhA/Elevated ECW/TBW (n = 323), and Lower PhA/Elevated ECW/TBW (n = 114). Logistic regression was used to assess the association with low physical function (Short Physical Performance Battery score ≤ 9) and low grip strength.
Results: After adjustment for demographic and clinical confounders, the Lower PhA/Elevated ECW/TBW group showed significant associations with both low physical function (OR = 3.07, 95% CI = 1.63-5.81) and low grip strength (OR = 2.41, 95% CI = 1.20-4.85), as well as their co-occurrence (OR = 3.10, 95% CI = 1.53-6.27). No significant associations were found for the Normal PhA/Elevated ECW/TBW group after adjustment.
Conclusion: The combination of a lower PhA and an elevated ECW/TBW ratio is significantly associated with poor muscle function. This combined BIA profile may serve as a useful, noninvasive screening tool for identifying individuals at high risk of functional decline in community settings.
期刊介绍：
Journal of the International Society of Sports Nutrition (JISSN) focuses on the acute and chronic effects of sports nutrition and supplementation strategies on body composition, physical performance and metabolism. JISSN is aimed at researchers and sport enthusiasts focused on delivering knowledge on exercise and nutrition on health, disease, rehabilitation, training, and performance. The journal provides a platform on which readers can determine nutritional strategies that may enhance exercise and/or training adaptations leading to improved health and performance.
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